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Epidermal growth factor receptors in human breast cancer (1984)

Pérez, Rolando ; Pascual, María ; Macías, Amparo ; [et al.]

Springer

Breast cancer research and treatment 4 (1984), S. 189-193

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ISSN: 1573-7217

Keywords: estrogen receptor ; breast cancer ; EGF receptor ; growth factors

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary The capacity for specific binding of125I-epidermal growth factor (EGF) was studied in crude membrane fractions from 95 human breast carcinomas. About 42% of the samples showed saturable, high affinity, specific binding of EGF. In 21% of the tumors we were able to demostrate high (above 10 fmoles/mg protein) binding capacity. Moreover, high EGF receptor values were associated with a low content of estradiol receptor. These studies are related to the definition of new biochemical markers in human breast cancer.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01806484

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