ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Cobalt-Catalyzed Cycloaddition of Alkynes and Nitriles to Pyridines: A New Route to Pyridoxine (Vitamin B6)A new synthesis of pyridoxine hydrochloride (1) based on a Co-catalyzed cycloaddition of MeCN with substituted di(2-propynyl) ethers (3 and 16) is described. The reaction sequences following cycloaddition and leading to 1 involve as key steps the rearrangement f the pyridine-N-oxide 6 to the 3-hydroxypyridine 7 with Ac2O and a modified Curtius rearrangement of the acid 19 and subsequent diazotation and hydrolysis to the same pyridoxine precursor 7, respectively. The intermediate 7 is transformed to 1 by well-known procedures.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19840670513
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