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  • 1
    Electronic Resource
    Electronic Resource
    HAEMODYNAMIC EFFECTS OF NO-SYNTHASE INHIBITORS, NG-MONOMETHYL-L-ARGININE, NG-NITRO-L-ARGININE AND NG-NITRO-L-ARGININE METHYL ESTER, AND NO-DONOR, GLYCERYL TRINITRATE, IN CONSCIOUS SHRSP AND WKY (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 22 (1995), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The experiments were carried out by an ordinary and a microsphere method in order to clarify the effects of three nitric oxide-synthase inhibitors and -donor on the circulating system between SHRSP and WKY.2. Intravenous administration of each compound possessing the nitric acid-synthase inhibiting action markedly elevated the systolic blood pressure both in SHRSP and WKY, but more prominently in the former.3. The hypotensive and tachycardic responses to glyceryl trinitrate were more enhanced after treatment with NO-nitro-L-arginine and NG-nitro-L-arginine methyl ester but not with NG-monomethyl-L-arginine compared with the non-treated one.4. All peripheral organs except the brain decreased their regional blood flow after administration of NG-nitro-L-arginine, indicating a crucial involvement of nitric oxide in the peripheral circulation.5. It was suggested that the nitric oxide system worked more sensitively and actively in SHRSP than in WKY in order to maintain the peripheral blood flow and systemic blood pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1995.tb02860.x
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  • 2
    Electronic Resource
    Electronic Resource
    COMPARATIVE HAEMODYNAMIC STUDIES OF ENDOTHELIN-1, -2 AND -3 ON CONSCIOUS SHRSP AND WKY (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 22 (1995), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Depressor and pressor effects of endothelin-1, -2 and -3 in relation to hypertension were investigated in conscious WKY and SHRSP.2. Changes of systolic arterial pressure to both depressor and pressor responses caused by three doses of endothelin-1, -2 or -3 (0.1, 0.3 and 1 nmol/kg) occurred to a similar extent between WKY and SHRSP. These data showed that endothelins may not exert an important role on the pathogenesis of hypertension.3. Endothelin-1 decreased the cardiac index more in SHRSP than in WKY, indicating the dominance of ETA receptors in SHRSP compared with WKY.4. ET-1 was the most potent vasodepressor and vasodilator of three endothelin peptides in rats.5. During the pressor responses to endothelin-1 and -3, cardiac arrhythmia was observed with high frequency in the animals of both groups, indicating the arrhythmogenic effect of ET.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1995.tb02880.x
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  • 3
    Electronic Resource
    Electronic Resource
    PROPER MEASUREMENT OF BLOOD PRESSURE AND HEART RATE IN SHRSP AND WKY BY AN INDIRECT VOLUME-OSCILLOMETRIC METHOD (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 22 (1995), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effect of environmental temperature on the indirect measurement of rat blood pressure and heart rate was investigated with special reference to the tail arterial blood flow in both strains of SHRSP and WKY.2. Very good correlations (r 〉 0.82, P 〈 0.05; t-test, 10 d.f.) were observed between the two values of systolic blood pressure or heart rate measured by a direct and an indirect method at environmental temperatures between 26 and 38°C in SHRSP, and 34 and 38°C in WKY, respectively.3. When the temperature was elevated by 10°C from 25°C to 35°C, the regional blood flow in the tail artery increased by 52–69%, sufficient to detect a blood flow increase by the indirect method.4. These data showed that the best way to measure the accurate blood pressure and heart rate in both strains of SHRSP and WKY by the indirect volume-oscillometric method was to hold the rats at 34–36°C for 5 min.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1995.tb02923.x
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  • 4
    Electronic Resource
    Electronic Resource
    TISSUE VARIATION OF ACUTE HAEMODYNAMIC CHANGES BY NG-NITRO-L-ARGININE IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE AND WISTAR-KYOTO RATS (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 24 (1997), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The acute effects of nitric oxide synthase inhibition on the haemodynamics in stroke-prone spontaneously hypertensive (SHRSP) and normotensive Wistar-Kyoto (WKY) rats were investigated using radiolabeled microspheres.2. Intravenous administration of 3 and 6 mg/kg NG-nitro-L -arginine (l.-NNA) caused a significant increase in total peripheral resistance, a decrease in cardiac output and an increase in blood pressure in both SHRSP and WKY rats.3. Significant decreases in regional blood flow (RBF) in the lung, muscle and stomach of WKY rats were observed following L-NNA administration.4. NG-nitro-L -arginine produced a 70% increase in brain regional blood flow at a dose of 6 mg/kg only in SHRSP.5. There was a variation in the involvement of nitric oxide (NO) in different tissues.6. It is concluded that hypertension in SHRSP augments NO-mediated vasodilation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1997.tb01815.x
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    Paper (German National Licenses)
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