ISSN:
1432-1041
Keywords:
indomethazine
;
rheumatoid arthritis
;
pharmacokinetics
;
tolerance
;
side effects
;
slow-release tablets
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The pharmacokinetics, efficacy and tolerance of a new formulation of slow-release indomethacin tablet were compared with those of a conventional indomethacin capsule in 30 patients with rheumatoid arthritis. The slow-release tablet was absorbed more slowly than the capsule (tmax 3.7 h and 〈 2 h, respectively) and produced more even serum drug levels in 10 subjects. Side-effects, especially dizziness and diarrhoea, were less frequent after the slow-release tablet than during the capsule period.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00613619
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