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  • 1
    Electronic Resource
    Electronic Resource
    Pyranoide Isomere des α- und β-Thymidins (1966)
    Springer
    Naturwissenschaften 53 (1966), S. 178-178 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00631472
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  • 2
    Electronic Resource
    Electronic Resource
    Über die Polyphosphate der Hele (1958)
    Springer
    Naturwissenschaften 45 (1958), S. 191-191 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00621342
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  • 3
    Electronic Resource
    Electronic Resource
    Modulation of the beta-adrenergic-response in cultured rat heart cells (1991)
    Springer
    Molecular and cellular biochemistry 102 (1991), S. 49-60 
    Details
    ISSN: 1573-4919
    Keywords: growth inhibitor ; modulation of beta-adrenergic response ; rat neonatal heart muscle cells ; lipid binding ; fatty acid-binding protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary ‘Mammary-derived growth inhibitor (MDGI)’ is a 14.5 kDa polypeptide with growth-inhibitory activity for various mammary epithelial cells in vitro which is highly homologous to cardiac fatty acid-binding protein (H-FABP). Here we describe a new biological activity of MDGI: Inhibition of L(+)-lactate-, arachidonic acid- and 15-S-hydroxyeicosatetraenoic acid-induced supersensitivity of neonatal rat heart cells for beta-adrenergic stimulation, concerning particularly a small population of beta2 receptors. Synthetic peptides corresponding to the MDGI-sequence, residue 121–131 mimic the effect of MDGI. Measurements of lipid-binding to MDGI and synthetic peptides excluded the binding of arachidonic acid, 15-S-hydroxyeicosatetraenoic acid or beta-adrenergic agonists to MDGI or the peptides as the mechanism for this effect. Also, no direct interference of MDGI and the synthetic peptides with the binding of the beta-adrenergic agent CGP 12177 to its receptor on A431 cells could be detected. We suggest that MDGI and the peptides act by interference with the function of the beta2-adrenergic receptor and that this mechanism might also be relevant for the growth-inhibitory activity of MDGI. Furthermore, the data point to a possible function of H-FABP for the modulation of beta-adrenergic sensitivity of cardiac myocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00232157
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  • 4
    Electronic Resource
    Electronic Resource
    Evidence for involvement of a nuclear envelope-associated RNA helicase activity in nucleocytoplasmic RNA transport (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 145 (1990), S. 136-146 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: It seems well established that translocation of at least some mRNAs through the nuclear pore is (1) an energy-dependent process, and (2) dependent on the presence of the poly(A) segment attached to most mRNA species. We describe that RNA helicase (RNA duplex unwindase) activity is present in a nuclear envelope (NE) preparation, which also appears to be involved in nucleocytoplasmic RNA transport. This activity unwinds RNA : RNA hybrids. The helicase has a pH optimum of 7.5 and a temperature optimum of 30°C. Applying the sealed NE vesicle system, it was shown that duplex RNA species are readily released from the vesicles in an unidirectional manner, in contrast to single-stranded RNA, which is much slower transported into the extravesicular space. Attachment of a poly(A) segment to the RNA duplex additionally increases the efflux rate of this RNA. Efflux of duplex RNA but not efflux of single-stranded RNA was strongly inhibited by formycin B 5′-triphosphate. Our results suggest that, besides poly(A), duplex structures, if present in a given RNA, modulate and control the export of RNA.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041450119
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  • 5
    Electronic Resource
    Electronic Resource
    Pyrimidin-nucleoside der 2-Desoxy-D-glucose (1965)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 98 (1965), S. 1988-1997 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Kondensation von 2-Desoxy-3.4.6-tri-O-acetyl-D-glucopyranosylbromid (I) mit Monoquecksilberverbindungen des Thymins, 5-Fluor-, 5-Brom-, 5-Joduracils und Uracils (IIa-e) in Dimethylformamid liefert nach basen- oder protonenkatalysierter Entacylierung die entsprechenden 1-[2-Desoxy-α.β-D-glucopyranosyl]-pyrimidin-Derivate (α.β-IVa-e). Die α- bzw. β-Anomeren wurden entweder isoliert oder angereichert. Die Untersuchung der Hemmwirkung dieser Nucleoside und ihrer Pyrimidin-Basen auf die Spaltung von Desoxyuridin durch Extrakte aus Ascites-Tumorzellen ergab, daß in allen Fällen die β-Anomeren wirksamer sind als die α-Anomeren und die freien Basen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19650980638
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  • 6
    Electronic Resource
    Electronic Resource
    Ein neuer Weg zu 3′-Desoxy-uridin aus Uridin (1968)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 101 (1968), S. 235-239 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Darstellung von 3′-Desoxy-uridin (3) aus Uridin über 1 und 2 wird beschrieben. 3 ist gegenüber saurer Hydrolyse relativ stabil. 3 hemmt in vitro weder die DNS- noch die RNS-Synthese von Ehrlich-Ascites-Tumorzellen. Die Verbindung vermag Nucleosid-Phosphorylasen nicht zu hemmen und wird durch diese Enzyme nicht gespalten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19681010131
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  • 7
    Electronic Resource
    Electronic Resource
    Nucleotidanaloge Thymidinsulfate (1966)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 99 (1966), S. 2725-2735 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Bei der Reaktion von Thymidin mit Chlorsulfonsäure, SO3-Pyridin oder SO3-Triäthylamin in verschiedenen Molverhältnissen werden nebeneinander die Nucleotidanalogen Thymidin-5′-sulfat,-3′-sulfat und -3′.5′-disulfat erhalten und deren jeweilige Anteile in den Reaktions-produkten bestimmt. Der Monosulfat-Anteil besteht überwiegend aus Thymidin-5′-sulfat, das wie Thymidin-3′.5′-disulfat als Na-Salz isoliert wird. Die beiden Monosulfate werden außerdem aus 3′- bzw. 5′-geschützten Thymidinen dargestellt. - Die Thymidinsulfate hemmen die Abspaltung von Phosphat aus 5′-Nucleotiden durch Enzyme der Kern-, Mitochondrien- und Mikrosomen-Fraktion aus Mäuseleber. Die Reihenfolge ihrer Hemm-Wirksamkeit ist bei den Enzymen verschiedener Herkunft teilweise recht unterschiedlich. Die Phosphatabspaltung aus Desoxyribonucleotiden wird wesentlich stärker gehemmt als diejenige aus Ribonucleotiden.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19660990903
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  • 8
    Electronic Resource
    Electronic Resource
    Anomere Thymin-nucleoside der 2-Desoxy-D-ribopyranose und 2-Desoxy-l-ribopyranose (1968)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 101 (1968), S. 226-234 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: D- und l-1-Chlor-3.4-di-O-acetyl-2-desoxy-ribopyranose (1 und 8) reagieren mit Monoquecksilberthymin (5) zu den entsprechenden anomeren Thymin-N-1-nucleosiden (α-2/β-2 und α-9/β-9). Die Perjodatoxydation der Nucleoside führt zu spiegelbildisomeren Nucleosiddialdehyden (6, 7). Die Anomerenpaare gehorchen nicht den Hudsonschen Isorotationsregeln. β-9 ist ein starker Hemmstoff der Uridin-Desoxyuridin-Phosphorylase aus Ascites Tumorzellen.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19681010130
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  • 9
    Electronic Resource
    Electronic Resource
    Thymin-nucleoside der 2-Desoxy-D-xylopyranose (1968)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 101 (1968), S. 494-501 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1-Chlor-3.4-di O-acetyl-2-desoxy-D-xylopyranose (2) reagiert sowohl mit 2.4-Bis-O-trimethyl-silyl-thymin (1) in Gegenwart von AgClO4 oder HgO/HgBr2 als auch mit Monoquecksilber-thymin (3) in Dimethylformamid zu einem Gemisch acetylierter Nucleoside, aus dem nach Entacetylierung durch Säulenchromatographie 1-[2-Desoxy-α-D-xylopyranosyl]-thymin (α-6) und sein β-Anomeres (β-6) isoliert werden können.
    Additional Material: 20 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19681010217
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