ISSN:
1432-1041
Keywords:
Fenoterol
;
pharmacokinetics, non-linearity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary We have studied the pharmacokinetics of fenoterol in healthy women during and after a 3 h intravenous infusion of different doses within the therapeutic range for tocolysis (0.5 μg·min−1, 1.0 μg·min−1, and 2.0 μg·min−1). A specific and sensitive radioimmuno-assay was used for the determination of fenoterol. For compartmental analysis the plasma concentration time data were fitted with the TOPFIT program, assuming two exponentials. The total clearance of fenoterol increased with dose (1299 ml·min−1 at 0.5 μg·min−1, 1483 ml·min−1 at 1.0 μg·min−1, and 1924 ml·min−1 at 2.0 μg·min−1), as did the apparent volume of distribution (from 491 at the lowest to 851 at the highest dose). In contrast, the apparent half-lives were not dose-dependent, with t1/2·λ 1 4.8 min and t1/2·λ 2 52 min.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02284970
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