ISSN:
1365-2559
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Aims : Cyclin D1 is a target molecule transcriptionally activated by aberrant β-catenin in Wnt signalling. Thyroid papillary microcarcinoma (PMC) may be considered a precursor of papillary thyroid cancer (PTC). Ki67 is widely used as a proliferation marker. The aim of this study was to determine whether cyclin D1 overexpression is involved in early thyroid carcinogenesis.Methods and results : Thirty-five cases of PMC were examined immunohistochemically, including 11 cases less than 5 mm (PMC 〈 5) and 24 cases more than 5 mm (PMC 〉 5), and 18 PTC cases (size 11–15 mm). Cyclin D1 expression was significantly lower in PMC 〈 5 than in PMC 〉 5, while there was no significant difference between PMC 〉 5 and PTC. Statistical analysis revealed significant correlations between cyclin D1 labelling index (LI) and Ki67 LI (P = 0.0272)/cytoplasmic β-catenin expression (P 〈 0.001) in PMC and PTC. Four of five PMC 〉 5 cases with lymph node (LN) metastases displayed a high cyclin D1 LI and strong cytoplasmic β-catenin expression.Conclusions : Cyclin D1 overexpression and correlation with aberrant β-catenin expression were demonstrated in PMC. Cyclin D1 expression was significantly associated with tumour size and LN metastases in PMC. Cyclin D1 may be up-regulated at an early stage of thyroid carcinogenesis and promote tumour growth and metastatic potency in PMC through activation of the Wnt/β-catenin pathway.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-2559.2005.02218.x
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