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  • 1
    Electronic Resource
    Electronic Resource
    Immunological Properties of Electrophoretic Fractions of Human Growth Hormone (1962)
    [s.l.] : Nature Publishing Group
    Nature 194 (1962), S. 491-492 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the present work the immunological properties of the individual components of human growth hormone were investigated. The hormone was prepared from human pituitaries according to Raben's6 method, and the same batch, ^4-3, was used throughout. The immunological methods used have been described in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/194491a0
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  • 2
    Electronic Resource
    Electronic Resource
    Immunological Investigations of Sheep Prolactin (1963)
    [s.l.] : Nature Publishing Group
    Nature 197 (1963), S. 299-300 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the work reported here the immunological properties of whole sheep prolactin (NIH-P-S-3) and its electro-phoretic components were investigated. The immunological methods used have been described previously in detail4. On agar-gel electrophoresis sheep prolactin showed thre" components (Fig. 1). ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/197299a0
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  • 3
    Electronic Resource
    Electronic Resource
    Insulin enhances the growth of cartilage in organ and tissue cultures of mouse neonatal mandibular condyle (1993)
    Springer
    Calcified tissue international 52 (1993), S. 291-299 
    Details
    ISSN: 1432-0827
    Keywords: Insulin ; Cartilage ; Growth ; Condyle ; Mandible ; Mouse ; In vitro
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Condylar cartilages were cultured in the form of organ cultures on top of collagen sponges in medium containing 2% fetal calf serum and were treated with 3.5–350 nM insulin for 6 days. Doses of 175 nM of insulin caused a marked increase (+96%) in DNA synthesis and in proteoglycan production (+74%), features that manifested themselves structurally by a 60% increase in overall size of the cultured explants. Using a tissue culture system comprised of cartilage progenitor cells, insulin was found to enhance the differentiation of the progenitor cells so that by 6 days in culture and appreciable nodule of differentiated chondrocytes developed. The latter was surrounded by perichondrial cells whereas the extracellular matrix within the newly formed, insulin-induced, nodule reacted positively for cartilagespecific antigens (type II collagen and bone sialoprotein). It is suggested that insulin induces a direct stimulatory effect on progenitor cell proliferation, cartilage differentiation, and extracellular matrix deposition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296654
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  • 4
    Electronic Resource
    Electronic Resource
    Plasma Disappearance of Various 131 I-labelled Growth Hormone Preparations in Man and Rabbit (1965)
    [s.l.] : Nature Publishing Group
    Nature 207 (1965), S. 298-299 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The growth hormone preparations used were: human growth hormone (HGH), sheep growth hormone (SGH, batch S6) and chymotrypsinized bovine growth hormone (BGH-(7F-75). The sheep growth hormone was used untreated or after pepsin digestion1. The labelling procedure with 131I was performed according to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/207298a0
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  • 5
    Electronic Resource
    Electronic Resource
    Renal function in Laron syndrome patients treated by insulin-like growth factor-I (1994)
    Springer
    Pediatric nephrology 8 (1994), S. 684-688 
    Details
    ISSN: 1432-198X
    Keywords: Insulin-like growth factor-I treatment ; Laron syndrome ; Renal function ; Glomerular filtration rate ; Tubular reabsorption of phosphorus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eight children with Laron syndrome (5 males, 3 females) aged 3–14.5 years received daily subcutaneous injections of 150 μg/kg recombinant insulin-like growth factor-I (IGF-I) for 5 months. The children were examined weekly for the 1st month and then once monthly. At each visit, overnight fasting blood was drawn for serum IGF-I and blood chemistry measurements and a 24-h urine collection was performed for the determination of calcium, phosphorus, creatinine and nitrogen. The main effects related to kidney function were: an initial weight gain with a mild transitory reduction in the urinary volume, an increase in serum electrolyte concentrations and a decrease in urinary electrolyte excretion. The lower than normal mean (± SEM) basal creatinine clearance (76.7±15.8 ml/min per 1.73 m2) increased towards the normal range during treatment to 124.9±13 ml/min per 1.73 m2, with a mean increment of 73.4±28% (P〈0.02) from basal values after 2 months of treatment, without changes in the serum creatinine. Initially an increase in blood urea nitrogen was observed together with a reduction in urinary nitrogen excretion. During the IGF-I therapy the urinary calcium excretion increased from 0.7±0.2 nmol/day to 1.5±0.3 nmol/day and the tubular reabsorption of phosphate increased from 1.24±0.06 to more than 1.38±0.04 nmol/l (P〈0.002), resulting in a significant increase in serum phosphate levels from 1.51±0.06 to more than 1.63±0.04 nmol/l (P〈0.005). The present study shows for the first time that long-term IGF-I deficiency in man results in a subnormal glomerular filtration rate and that chronic substitution therapy with IGF-I has marked renotropic effects identical to those ascribed to growth hormone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00869089
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  • 6
    Electronic Resource
    Electronic Resource
    The LH and FSH responses to LH-releasing hormone (LH-RH) in girls with true precocious puberty treated with cyproterone acetate (1977)
    Springer
    European journal of pediatrics 125 (1977), S. 205-212 
    Details
    ISSN: 1432-1076
    Keywords: Precocious puberty ; Cyproterone acetate ; Basal and peak levels of gonadotrophins ; Release of gonadotrophins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Ten girls with precocious puberty ranging in age from 7 to 10 7/12 years who were treated with oral cyproterone acetate on a long term basis, were subjected to LH-RH tests, prior to and 3 to 16 months after the institution of therapy. Cyproterone acetate was given in doses from 60 to 153 mg/m2, which proved to be clinically effective, as evidenced by the slowing down of sexual maturation. The basal levels of LH were found to be unaffected by therapy and corresponded to the pubertal stages of the individual girls. The peak increment of LH after LH-RH stimulation was markedly suppressed by the therapy. FSH secretion and its responsiveness to LH-RH was not affected by cyproterone acetate. The basal levels of FSH were higher during therapy than before, but the peak FSH increment remained the same. An escape phenomenon in the LH peak response was evident in 2 patients upon retesting after prolonged therapy. It is possible that the antigonadotrophic action of cyproterone acetate is due to its progestational nature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00480598
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  • 7
    Electronic Resource
    Electronic Resource
    Prolactin secretion in 70 patients with growth hormone deficiency (1980)
    Springer
    European journal of pediatrics 133 (1980), S. 251-258 
    Details
    ISSN: 1432-1076
    Keywords: Pituitary insufficiency ; Growth hormone deficiency ; Prolactin ; TSH ; TRH ; Pituitary tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The basal levels of prolactin (PRL) and its response to TRH stimulation were studied in 70 patients with growth hormone deficiency of various etiology. It was found that there was a low secretion of PRL which was in most cases associated with a low response of TSH to TRH as well in 8 (36%) of 22 patients with so-called isolated growth hormone deficiency (IGHD) and 3 of 21 patients with multiple pituitary hormone deficiencies (MPHD). On the basis of this observation it is suggested that IGHD patients found to have a deficiency of PRL be reclassified as suffering form MPHD due to pituitary disease. High basal levels of PRL, usually associated with a delayed response of TSH to TRH, were found in 2 patients with IGHD and in 8 with MPHD (prior to substitution therapy with thyroxine) in whom the deficiency is probably: due to disease of the hypothalamus. With two exceptions the PRL levels normalized in the MPHD patients following institution of thyroxine replacement treatment. In the idiopathic cases of GH deficiency the determination of PRL levels was therefore found to be useful in delineating the location of the defect and in correctly classifying individual patients. Among the patients with tumors a disturbance in PRL secretion was found preoperatively in 4 of the 6 cases studied, the low PRL response in 2 being suggestive of a pituitary disturbance. Post-operatively evaluation of the PRL secretion was found useful in assessing the completeness of hypophysectomy and the persistence or recurrence of the tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00496085
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  • 8
    Electronic Resource
    Electronic Resource
    Puberty in Laron type dwarfism (1980)
    Springer
    European journal of pediatrics 134 (1980), S. 79-83 
    Details
    ISSN: 1432-1076
    Keywords: Puberty ; Laron-type dwarfism ; Growth hormone ; Pituitary dwarfism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The onset and progress of puberty was followed in 18 patients (7 males and 11 females) with Laron-type dwarfism (LTD). The boys had delayed puberty, testicular enlargement occurring between 12–14 years being the first sign. The first conscious ejaculation occurred between 17–21 years and full maturity was reached after the age of 22. In girls menarche occurred between 13–14 years and full maturity was reached between 16–19 years. Two patients—one male and one female—have children.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442408
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  • 9
    Electronic Resource
    Electronic Resource
    Self-image in adolescents with delayed puberty and growth retardation (1981)
    Springer
    Journal of youth and adolescence 10 (1981), S. 501-505 
    Details
    ISSN: 1573-6601
    Source: Springer Online Journal Archives 1860-2000
    Topics: Sociology
    Notes: Abstract Fifty-six adolescents with varying combinations of pubertal delay and growth retardation were given the Offer Self-Image Questionnaire. Delay in sexual maturation by itself had no significant deleterious effect on self-image; however, growth retardation did. These results have important implications in determining indications for the endocrinological treatment of pubertal disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02087942
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