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  • 1
    Electronic Resource
    Electronic Resource
    Acetylcholine- and inositol 1,4,5-trisphosphate-induced calcium mobilization in Xenopus laevis oocytes
    Amsterdam : Elsevier
    FEBS Letters 199 (1986), S. 208-212 
    Details
    ISSN: 0014-5793
    Keywords: (Xenopus) ; Ca^2^+ mobilization ; Inositol trisphosphate ; Muscarinic response ; Oocyte
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(86)80481-1
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Synaptic frequency demodulation (1972)
    Springer
    Cellular and molecular life sciences 28 (1972), S. 1033-1035 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Die synaptische Übertragung von Reizmustern wurde an der neuromuskularen Synapse beiRana ridibunda geprüft. Der Nerv wurde mit einer sinusoidal modulierten Frequenz gereizt und die postsynaptischen Potentiale intrazellulär abgeleitet. Daraus wird geschlossen, dass die Synapse Veränderungen in der Einsatzfrequenz überträgt, die einem “Low-pass”-Filter gleichkommt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01918654
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  • 3
    Electronic Resource
    Electronic Resource
    Facilitation of synaptic transmission by diazepam in a perfused frog cerebellum (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 1484-1484 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The action of diazepam on the parallel fibres-Purkinje cell synapse was studied in a perfused frog cerebellum. Diazepam facilitates the excitatory input to Purkinje cells and hence increases the inhibition produced by Purkinje cells activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01918822
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Electro-mechanical noise in atrial muscle fibres of the carp (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 1058-1060 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Steady membrane voltage fluctuations have been observed in atrial muscle fibres of the carp. These voltage fluctuations produce minute mechanical oscillations, as revealed by an interference contrast microscope. The steady voltage fluctuations may be related to abnormal automaticity in the heart.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01945968
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Offset rate of action of muscarinic antagonists depends on their structural flexibility (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 650-652 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Time course measurements of the action of muscarinic antagonists were performed in the spontaneously beating carp atrium. Several high affinity drugs, which embody the quinuclidine structure were examined. The structural flexibility of these molecules was reflected in the dissociation of the drugs from the muscarinic receptor. The dissociation of rigid drugs was very much prolonged as compared to flexible drugs of the same affinity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01960378
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  • 6
    Electronic Resource
    Electronic Resource
    A new model for transmitter mobilization in the frog neuromuscular junction (1973)
    Springer
    Pflügers Archiv 343 (1973), S. 157-163 
    Details
    ISSN: 1432-2013
    Keywords: Depression ; Mobilization, Release Fraction ; Synapse ; Transmitter Stores
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The detubulated neuromuscular preparation was stimulated by several thousand stimuli at the rate of 10–20 Hz. During the stimulation there was an exponential decay in transmitter release from the presynaptic terminal. The fraction of the existing store of quanta released by a single pulse was about 0.001. This value is two orders of magnitude smaller than that obtained from short tetanic trains. The discrepancy was attributed to the process of mobilization which sets in during prolonged stimulation of the synapse. A simple analysis shows that the amount of transmitter mobilized after each nerve impulse is a constant fraction of the existing store of quanta.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00585711
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  • 7
    Electronic Resource
    Electronic Resource
    Transmission of information by the axon: I. Noise and memory in the myelinated nerve fiber of the frog (1975)
    Springer
    Biological cybernetics 19 (1975), S. 61-67 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract One end of the frog sciatic nerve was stimulated with a pair of short pulses and the two action potentials arriving at the other end were recorded from a single fiber. The interval between the two stimuli (stimulus interval) was defined as the input to the channel. The interval between the two action potentials arriving at the other end of the nerve (response interval) was defined as the output of the channel. Repeated stimulation with a constant stimulus interval resulted in a population of response intervals. In the range between the absolute refractory period and 5 msec, the mean response interval was longer than the stimulus interval. In the range between 5–120 msec the mean response interval was shorter than the stimulus interval. This relation depended also on the “history” of the axon and intense activity tended to increase the difference. For intervals longer than 120 msec, the mean response interval was equal to the stimulus interval. The “noise” of the transmission along the axon was approximately Gaussian. At stimulus strength which was well above threshold only few μsec of uncertainty were added along 10 cm of the axon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00364102
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  • 8
    Electronic Resource
    Electronic Resource
    Transmission of information by the axon: II. The channel capacity (1975)
    Springer
    Biological cybernetics 19 (1975), S. 121-125 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract The rate of transmission of information by the axon was analyzed in terms of the information theory. It is concluded that the Poisson rather than the uniform density function is optimal for the maximal rate of transmission in a nervous channel using interval code. If the refractory period is neglected, the information capacity $$\left( {\frac{{nat}}{{sec}}} \right)$$ and the optimal mean rate of firing $$\left( {\frac{{impulse}}{{sec}}} \right)$$ are equal and given by: $$(1/2\pi eN)^{\mathop {\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle-}$}}{1} }\limits_2 }$$ where N is the variance of the jitter in the interval between the action potential. Under physiological conditions, the channel capacity and the optimal mean rate of firing are limited by both the refractory period and the noise. Figures 1 and 2 allow the calculation of the capacity and the optimal mean firing rate for any given refractory period and “noise” level. The analysis is applicable for neuronal channels in which each stimulus produces a single spike and the noise results from the jitter in either the propagation velocity or the synaptic delay.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00337250
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