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  • 1
    Electronic Resource
    Electronic Resource
    On the Neural Connection (2001)
    Oxford, UK : Blackwell Science Inc
    Journal of cardiovascular electrophysiology 12 (2001), S. 0 
    Details
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: On the Neural Connection Discoveries concerning cardiac neural-electrical modulation and local neural remodeling provide powerful new approaches for the development of novel antiarrhythmic strategies. This “view” of developments in this emerging field highlights recent advances and suggests that additional neurally targeted investigations have considerable potential for prevention of arrhythmic diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1540-8167.2001.00841.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Clearer Connections: (2004)
    350 Main Street , Malden , MA 02148-5018 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Science Inc
    Journal of cardiovascular electrophysiology 15 (2004), S. 0 
    Details
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1540-8167.2004.03643.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of polymeric motion on fluorine-19 NMR multiple quantum coherences: signal refocusing in poly(tetrafluoroethylene) (1993)
    s.l. : American Chemical Society
    Macromolecules 26 (1993), S. 4652-4657 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma00069a036
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Concentration- and rate-dependent electrophysiological effects of restacorin on isolated canine purkinje fibres (1990)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 342 (1990), S. 691-697 
    Details
    ISSN: 1432-1912
    Keywords: Restacorin ; Electrophysiology ; Antiarrhythmic drugs ; Recovery of $$\dot V$$ max ; APD restitution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The cellular electrophysiological effects of restacorin, a new antiarrhythmic agent were studied using conventional microelectrode techniques in isolated dog cardiac Purkinje fibres. Restacorin (1 – 30 µmol/l) decreased the maximum rate of rise of the action potential upstroke and action potential amplitude while action potential duration measured at 90% of repolarization was shortened in a concentration-dependent manner during pacing at a constant basic cycle length of 500 ms. The effect of 10 µmol/l restacorin on maximal rate of rise of the action potential upstroke and on action potential duration measured at 90% of repolarization were also studied while varying the constant pacing cycle length between 300 and 5000 ms. The results of these studies indicated a rate-dependent effect of restacorin on the action potential characteristics examined. After abrupt changes in cycle length, 10 µmol/l restacorin slowed the fast component of the relation for restitution of action potential duration from 155.3 ± 5.2 ms (control, n = 6) to 217.1 ± 17.8 ms (n = 6, P 〈 0.05). In the presence of restacorin (10 µmol/l), a second slow component for recovery of maximal action potential up stroke rising velocity was expressed having a time constants of 8.5 ± 1.2 s. The range of premature action potential durations was significantly decreased (by 57.1%, P 〈 0.01) by 10 µmol/l restacorin. These results indicate that the cellular electrophysiological effects produced by restacorin in dog cardiac Purkinje fibres best resemble those produced by recognized class Ic antiarrhythmic drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175714
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of altered extracellular potassium and pacing cycle length on the class III antiarrhythmic actions of dofetilide (UK-68,798) in guinea-pig papillary muscle (1992)
    Springer
    Cardiovascular drugs and therapy 6 (1992), S. 429-436 
    Details
    ISSN: 1573-7241
    Keywords: dofetilide ; UK-68,798 ; class III antiarrhythmic agent ; action-potential duration ; repolarization ; potassium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of altered extracellular K+ concentrations ([K+]0) and pacing cycle lengths (CLs) on the electrophysiological actions of dofetilide (UK-68,798), a potent class III antiarrhythmic agent, were examined in isolated guineapig ventricular papillary muscle. At a normal [K+]0 (4 mM) and at CL between 300 and 5000 msec, dofetilide (10 nM) significantly increased the action-potential duration (APD) and the effective refractory period (ERP), whereas other action-potential parameters were unaffected. Elevation of [K+]0 to 10 mM reduced membrane diastolic potential (MDP), action-potential amplitude (APA), and the maximum rising velocity of the action-potential upstroke (Vmax). These changes were accompanied by a small shortening of APD90, but with an increase in ERP; i.e., the ERP/APD90 ratio was increased. Dofetilide also significantly lengthened APD90 at 10 mM [K+]0 and at each CL. Even at the short cycle lengths (300 and 500 msec), dofetilide-induced increases in APD90 were not attenuated whether [K+]0 was at 4 or 10 mM. These results indicate that at various pacing CLs, 10 nM dofetilide increases myocardial APD and ERP to a similar extent without significant reverse use-dependence when the cell membrane is normally polarized or partially depolarized by elevated [K+]0. Dofetilide may, therefore, be expected to be beneficial in the treatment of cardiac tachyarrhythmias related or unrelated to regional myocardial hyperkalemia during myocardial ischemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00054193
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    Paper (German National Licenses)
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