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  • 1
    Electronic Resource
    Electronic Resource
    Pelger–Huët Anomaly in Australian Shepherds: 87 Cases (1991–1997) (2000)
    Springer
    Comparative clinical pathology 10 (2000), S. 9-13 
    Details
    ISSN: 1433-2981
    Keywords: Key words:Australian shepherd – Autosomal dominant – Dog – Incomplete penetrance – Inheritance – Leucocytes – Pelger–Hue¨t anomaly
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Blood smears from 892 Australian shepherds were evaluated for the presence of Pelger–Hue¨t (P-H) anomaly over a 6-year period. During the study, 87 dogs were diagnosed with P-H anomaly (9.8% incidence) following microscopic examination of Wright–Leishman–stained blood smears. Granulocytes from dogs with P-H anomaly had nuclear hyposegmentation resembling bands and metamyelocytes; however, the chromatin pattern was more aggregated than that observed in mature segmenters. The granulocyte morphology of dogs with P-H anomaly was similar to that described for humans and rabbits with the heterozygous form of P-H anomaly. Where gender was known, 9.4% of males and 8.8% of females had P-H anomaly, indicating autosomal transmittance of the trait. None of the dogs with P-H anomaly had a predominance of granulocytes with round to oval nuclei (myelocytes) and an extremely coarse chromatin pattern, suggestive of the homozygous form of the anomaly. Because this phenotype was not observed in Australian shepherds, the homozygous form of P-H anomaly may be a lethal trait in utero. Six dogs with P-H anomaly had parents with a normal leucocyte phenotype. In addition, the incidence of P-H anomaly in F1 puppies from matings of individuals with normal and P-H phenotypes was less than expected. These observations strongly suggest that P-H anomaly is transmitted as an autosomal dominant trait with incomplete or decreased penetrance in Australian shepherds. Transmittance of P-H anomaly in this breed of dogs may be governed by more than one allele or expression of the anomaly may modified by genes at a different locus or loci.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005800070021
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Acute monocytic leukaemia (M5a) in a horse (1996)
    Springer
    Comparative clinical pathology 6 (1996), S. 111-114 
    Details
    ISSN: 1433-2981
    Keywords: Alpha naphthyl acetate esterase ; Cytochemistry ; Horse ; Monocyte ; Monocytic leukaemia ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acute monocytic leukaemia (M5a) was diagnosed in a 17-year-old Standardbred gelding with lethargy, intermittent pyrexia, oedema of the limbs, harsh lung sounds and submandibular lymphadeopathy. Haematological findings included moderately severe anaemia, thrombocytopenia and a leucocyte count within the reference interval, but characterised by neutropenia and numerous blast cells. Monocytic lineage of the cell population was suggested by examination of Wright-Leishman-stained blood and bone marrow smears. A panel of cytochemical stains disclosed diffuse cytoplasmic α-naphthyl-acetate esterase activity which could be markedly inhibited or abolished in all leukaemic cells by pretreatment with sodium fluoride. In ultrastructural preparations of buffy coat, neoplastic monoblasts had one to two nucleoli, dispersed chromatin, elongated mitochondria, scattered profiles of rough endoplasmic reticulum, bundles of microfilaments and pseudopodia. More differentiated monocytoid cells had infrequent lysosomal granules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426052
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Sezary syndrome in a dog (1996)
    Springer
    Comparative clinical pathology 6 (1996), S. 115-119 
    Details
    ISSN: 1433-2981
    Keywords: Alpha naphthyl acetate esterase ; Cytochemical staining ; Dog ; Epidermotropic lymphosarcoma ; Leukaemic blood picture ; Sézary syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sézary syndrome was diagnosed in a dog with epidermotropic lymphosarcoma and a leukaemic blood picture wherein 73.5% of the leucocytes (15582 of 21200 leucocytes /µl of blood) were large mononuclear cells with markedly convoluted nuclei. The dog had a history of multiple skin tumours progressing to hepatosplenomegaly and lymphadenopathy. Alpha-naphthyl acetate esterase staining of blood smears and splenic imprints revealed a focal to multifocal pattern of cytoplasmic enzyme activity that resisted sodium fluoride inibition, indicating that the neoplastic mononuclear cells were T lymphocytes. The neoplastic cells were negative for Sudan black B staining, myeloperoxidase activity, and chloroacetate esterase activity. Ultrastructurally, these cells had convoluted to cerebriform nuclei, 1 to 2 nucleoli, scattered mitochondria, numerous free ribosomes, and a few profiles of rough endoplasmic reticulum. Histological study of tissues collected at necropsy revealed infiltration of the skin, lymph nodes, spleen, liver, and bone marrow with neoplastic lymphocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426053
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Comparison of three animal viruses with circular single-stranded DNA genomes (1991)
    Springer
    Archives of virology 117 (1991), S. 129-135 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary No common antigenic determinants and no DNA sequence homologies were detected when three animal viruses, chicken anaemia agent (CAA), porcine circovirus (PCV), and psittacine beak and feather disease virus (PBFDV), all of which possess circular single-stranded DNA genomes, were compared. Negative contrast electron microscopy showed that PCV and PBFDV particles were 30% smaller than CAA particles and lacked the surface structure of CAA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01310498
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  • 5
    Electronic Resource
    Electronic Resource
    Beak and feather disease virus and porcine circovirus genomes: intermediates between the geminiviruses and plant circoviruses (1998)
    Springer
    Archives of virology 143 (1998), S. 1723-1744 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary.  Circoviruses are a diverse group of animal and plant pathogens with undefined relationships to one another but for their non-geminate, non-enveloped capsids and circular, single-stranded DNA genomes. The sequences of the beak and feather disease virus and porcine circovirus genomic DNAs are presented and analyzed in the context of the other members of the family. Sequence comparisons, inferred phylogenies, and geographic occurrence suggest that the ambisense circoviruses, particularly the beak and feather disease virus, represent an evolutionary link between the geminiviruses and the plant circoviruses. We propose that the family members be reclassified into three groups: The family Circoviridae consists of the animal pathogens (beak and feather disease virus and porcine circovirus) that possess ambisense genomes with striking similarities to the geminiviruses. The BBTV-like viruses include the plant pathogens (coconut foliar decay virus, banana bunchy top virus, subterranean clover stunt virus) with a geminivirus-like stem-loop element in their DNAs, and single to multiple component genomes. The chicken anemia virus is an unassigned virus possessing unique characteristics bearing little similarity to the other ssDNA viruses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007050050412
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    Paper (German National Licenses)
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