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  • 1
    Electronic Resource
    Electronic Resource
    Is there an earlier phylogenetic precursor that is common to both the nervous and endocrine systems?
    Amsterdam : Elsevier
    Peptides 3 (1982), S. 211-215 
    Details
    ISSN: 0196-9781
    Keywords: Evolution ; Hormonal peptides ; Neuropeptides
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0196-9781(82)90080-8
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    New concepts in regulation and function of the insulin-like growth factors: implications for understanding normal growth and neoplasia (2000)
    Springer
    Cellular and molecular life sciences 57 (2000), S. 932-942 
    Details
    ISSN: 1420-9071
    Keywords: Key words. Insulin-like growth factors; IGF-I receptor; cancer; receptor signaling.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. The insulin-like growth factors (IGFs) are a ubiquitous family of growth factors, binding proteins and receptors that are involved in normal growth and development. They are also implicated in numerous pathological states, including malignancy. IGF-II is a commonly expressed growth factor in many tumors and may enhance tumor growth, acting via the overexpressed IGF-I receptor, a cell-surface tyrosine kinase receptor. The IGF-I receptor may be overexpressed due to mutations in tumor suppression gene products such as p53 and WT-1 or growth factors such as bFGF and PDGF. Thus, this family of growth factors, especially the IGF-I receptor, may present an excellent target for new therapeutic agents in the treatment of cancer and other disorders of excessive cellular proliferation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00000735
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The growth hormone/insulin-like growth factor-I system: implications for organ growth and development (2000)
    Springer
    Pediatric nephrology 14 (2000), S. 544-549 
    Details
    ISSN: 1432-198X
    Keywords: Key words Growth hormone ; Insulin-like growth factor-I ; Growth ; Development ; Knock-out mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Growth hormone (GH) and insulin-like growth factors (IGFs) are essential for normal growth and development during embryonic stages as well as postnatally. While GH has little effect on these processes prenatally, the IGFs are important during these stages. On the other hand the GH-IGF-I axis is important for pubertal growth. To determine whether postnatal growth and development are dependent on circulating or locally produced IGF-I, we deleted the IGF-I gene in the liver using the cre/LoxP system used for tissue-specific gene deletion. These animals demonstrated approximately 75%–80% reduction in circulating IGF-I and an approximate fourfold increase in circulating GH. Despite the marked reductions in circulating IGF-I, growth and development was apparently normal. Thus the original somatomedin hypothesis needs to be re-evaluated in the light of these new findings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670000363
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    Paper (German National Licenses)
    Fulltext
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