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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 21 (1991), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A group of six mouse monoclonal antibodies (MoAbs) with the unusual lambda-type light chain were generated by fusion of NS-1 cells with splenic cells derived from BALB/c mice immunized with crude extracts of Bermuda grass pollen (BGP). Four of them were IgG1, one was IgG2b, and one was IgG3. Binding inhibition assay showed that they recognized the same (or very similar) epitope. Using sera from BGP-allergic patients, it was found that the specific binding between the IgE antibodies and the MoAb 26–11-fixed antigen could be blocked by MoAb 26–11 itself and another MoAb 9–13 in a dose-dependent manner. It appears that the epitope recognized by the lambda-type MoAbs is a human IgE-binding antigenic determinant. Further physicochemical analyses showed that this epitope was stable under heat but sensitive to treatments of sodium periodate and proteinase K. Results from these studies indicate that this unique epitope which leads to the generation of lambda-type MoAbs is part of a glycoprotein.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A panel of 16 monoclonal antibodies (MoAbs) directed against Bermuda grass (Cynodon dactylon) pollen (BGP) were generated for identification and purification of the major allergenic components of the eliciting antigen (Ag). Radioimmunoprecipitation (RIP) analysis revealed that there were at least eight antigenic components with molecular weights (MW) ranging from 12 kilodalton (12 kDa) to 200 kDa. Each of these components has distinct biochemical characteristics based on sodium dodecyl sulfate – polyacrylamide gel electrophoresis (SDS-PAGE) and isoelectric focusing(IEF). Among them, Cyn d Bd67K and Cyn d Bd58K were basic proteins, Cyn d Bd35K consisted of at least four isomeric components with isoelectric points ranging from 6.2 to 7.2. The other antigens Cyn d Bd68K, 48K, 38K, Cyn d Bd200K, Cyn d Bd46K, Cyn d Bd25K and Cyn d Bd12K) were all acidic proteins. The IgE binding capacity of all these antigens was determined with sera from 11 BGP-allergics by using a modified radioallergosorbent test. All but one of the antigens (Cyn d Bd200K) were found to react with human IgE from sera of BGP-allergic patients. Among those human IgE-binding molecules, Cyn d Bd35K. reacted with allergic sera most frequently (10 of 11), followed by Cyn d Bd58K (8 of 11) and Cyn d Bd46K (7 of 11) respectively. Our results suggest that Cyn d Bd35K, Cyn d Bd58K, and Cyn d Bd46K are major allergens of BGP, and the MoAbs we obtained should be valuable tools for further purificaiton of these allergens.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Computing 36 (1986), S. 1-16 
    ISSN: 1436-5057
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung Diese Arbeit untersucht das folgende Optimierungsproblem: gegeben sei eine Menge von PunktenP i ,i=1,2, ...,n, in der Ebene, jeder mit Gewichtw i , und eine Kreisscheibe mit vorgegebenem Radius; finde eine Plazierung der Kreisscheibe, die die Summe der Gewichte aller überdeckten Punkte maximiert. Dieses Problem ist äquivalent zum folgenden Problem definiert für den Schnittgraphen vonn kongruenten gewichteten Kreisscheiben in der Ebene: bestimme eine Clique (die korrespondierenden Kreisscheiben haben einen nichtleeren gemeinsamen Durchschnitt), die die Summe der Gewichte maximiert. Wir präsentieren einenO (n 2)-Algorithmus für dieses Problem, was eine Verbesserung darstellt gegenüber dem besten bisher bekannten Algorithmus, der sortiert undO (n 2 logn) an Laufzeit benötigt.
    Notes: Abstract We consider the following circle placement problem: given a set of pointsp i ,i=1,2, ...,n, each of weightw i , in the plane, and a fixed disk of radiusr, find a location to place the disk such that the total weight of the points covered by the disk is maximized. The problem is equivalent to the so-called maximum weighted clique problem for circle intersection graphs. That is, given a setS ofn circles,D i ,i=1,2, ...,n, of the same radiusr, each of weightw i , find a subset ofS whose common intersection is nonempty and whose total weight is maximum. AnO (n 2) algorithm is presented for the maximum clique problem. The algorithm is better than a previously known algorithm which is based on sorting and runs inO (n 2 logn) time.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    BIT 23 (1983), S. 456-471 
    ISSN: 1572-9125
    Keywords: Analysis of algorithms ; convexity ; rectilinear polygons
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract We study the class of rectilinear polygons, calledX – Y polygons, with horizontal and vertical edges, which are frequently used as building blocks for very large-scale integrated (VLSI) circuit layout and wiring. In the paper we introduce the notion of convexity within the class ofX – Y polygons and present efficient algorithms for computing theX – Y convex hulls of anX – Y polygon and of a set ofX – Y polygons under various conditions. Unlike convex hulls in the Euclidean plane, theX – Y convex hull of a set ofX – Y polygons may not exist. The condition under which theX – Y convex hull exists is given and an algorithm for testing if the given set ofX – Y polygons satisfies the condition is also presented.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    BIT 24 (1984), S. 333-340 
    ISSN: 1572-9125
    Keywords: SIMD computer ; systolic computer ; parallel algorithm ; graph algorithm ; time complexity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract Parallel algorithms for some graph-theoretic problems on a tree-structured computer are presented. In particular, ifp denotes the number of processing elements, algorithms that run inO(n 2/p) time for finding connected components, transitive closure and the minimum spanning tree of an undirected graph withn vertices are obtained.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    BIT 25 (1985), S. 76-90 
    ISSN: 1572-9125
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract This paper uses a new formulation of the notion of duality that allows the unified treatment of a number of geometric problems. In particular, we are able to apply our approach to solve two long-standing problems of computational geometry: one is to obtain a quadratic algorithm for computing the minimum-area triangle with vertices chosen amongn points in the plane; the other is to produce an optimal algorithm for the half-plane range query problem. This problem is to preprocessn points in the plane, so that given a test half-plane, one can efficiently determine all points lying in the half-plane. We describe an optimalO(k + logn) time algorithm for answering such queries, wherek is the number of points to be reported. The algorithm requiresO(n) space andO(n logn) preprocessing time. Both of these results represent significant improvements over the best methods previously known. In addition, we give a number of new combinatorial results related to the computation of line arrangements.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 252 (1972), S. 162-167 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We consider the contribution of crossed diagrams to the self-energy for a system of free electrons and fixed point impurities in the presence of a strong magnetic field. At the peaks of the Shubnikov-de Haas (S.d.H.) oscillations the dependence on the impurity concentration of the crossed diagram is the same as in the generalized Born approximation (n i 2/3 ). Nevertheless, for the S.d.H. regime the contribution of the crossed diagrams is shown to be unimportant.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0541
    Keywords: Shortest paths ; Interval graphs ; Circular-arc graphs ; Union-find algorithms ; Minimum circle cover
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract We give the first linear-time algorithm for computing single-source shortest paths in a weighted interval or circular-arc graph, when we are given the model of that graph, i.e., the actual weighted intervals or circular-arcsand the sorted list of the interval endpoints. Our algorithm solves this problem optimally inO(n) time, wheren is the number of intervals or circular-arcs in a graph. An immediate consequence of our result is anO(qn + n logn)-time algorithm for the minimum-weight circle-cover problem, whereq is the minimum number of arcs crossing any point on the circle; then logn term in this time complexity is from a preprocessing sorting step when the sorted list of endpoints is not given as part of the input. The previously best time bounds were0(n logn) for this shortest paths problem, andO(qn logn) for the minimum-weight circle-cover problem. Thus we improve the bounds of both problems. More importantly, the techniques we give hold the promise of achieving similar (logn)-factor improvements in other problems on such graphs.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Algorithmica 23 (1999), S. 187-210 
    ISSN: 1432-0541
    Keywords: Key words. Interval graphs, Partitioning, Clique-width, Sleep mode.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract. For a set S of intervals, the clique-interva I S is defined as the interval obtained from the intersection of all the intervals in S , and the clique-width quantity w S is defined as the length of I S . Given a set S of intervals, it is straightforward to compute its clique-interval and clique-width. In this paper we study the problem of partitioning a set of intervals in order to maximize the sum of the clique-widths of the partitions. We present an O(n log n) time algorithm for the balanced bipartitioning problem, and an O(k n 2 ) time algorithm for the k -way unbalanced partitioning problem.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Algorithmica 1 (1986), S. 193-211 
    ISSN: 1432-0541
    Keywords: Location problem ; 1-line center ; Maximum gap ; Computational geometry ; Lower bound
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract Given a set ofn demand points with weightW i ,i = 1,2,...,n, in the plane, we consider several geometric facility location problems. Specifically we study the complexity of the Euclidean 1-line center problem, discrete 1-point center problem and a competitive location problem. The Euclidean 1-line center problem is to locate a line which minimizes the maximum weighted distance from the line (or the center) to the demand points. The discrete 1-point center problem is to locate one of the demand points so as to minimize the maximum unweighted distance from the point to other demand points. The competitive location problem studied is to locate a new facility point to compete against an existing facility so that a certain objective function is optimized. An Ω(n logn) lower bound is proved for these problems under appropriate models of computation. Efficient algorithms for these problems that achieve the lower bound and other related problems are also given.
    Type of Medium: Electronic Resource
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