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  • 1
    Electronic Resource
    Electronic Resource
    Spatial Dispersion of Action Potential Duration Restitution Kinetics Is Associated with Induction of Ventricular Tachycardia/Fibrillation in Humans (2004)
    350 Main Street , Malden , MA 02148-5018 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Science Inc
    Journal of cardiovascular electrophysiology 15 (2004), S. 0 
    Details
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Introduction: Action potential duration restitution (APDR) plays a role in initiation and maintenance of ventricular tachycardia (VT)/ventricular fibrillation (VF). We hypothesized that the steeply sloped APDR and its spatial heterogeneity contribute to VT/VF inducibility in patients with ventricular arrhythmia. Method and Results: After programmed ventricular stimulation (PVS) for evaluation of clinically documented VT, patients (n = 20, 15 male, age 52.5 ± 9.5 years) were divided into two groups: inducible sustained VT/VF (IVT, n = 10) and noninducible VT/VF (NVT, n = 10). Data were compared with the corresponding results obtained from normal controls (C, n = 10). Right ventricular (RV) monophasic action potential duration at 90% repolarization (APD90) and ventricular effective refractory period (VERP) in the right ventricular apex (RVA) and right ventricular outflow tract (RVOT) were determined. APDR was acquired by scanning diastole with premature ventricular beats during a pacing cycle length of 600 msec (S1-S2) in all patients and by rapid pacing at the cycle lengths that induced APD alternans in three patients. Maximal slopes (Smax) of the APDR curves and ΔAPD90 (APD90 at S2 400 ms – APD90 at the shortest S2) were measured. VERP and APD90 at each RV site did not differ among the three groups. Smax obtained by S1-S2 (1.6 ± 0.6) did not differ from Smax obtained by rapid pacing (1.2 ± 0.7), with a significant correlation noted between these values (r = 0.92, P 〈 0.01). The IVT group had a higher spatial dispersion of Smax (Smax at RVOT – Smax at RVA) compared to the C group (P 〈 0.05), with no difference between the NVT group and the IVT or C groups. The IVT group had a higher spatial dispersion of ΔAPD90 compared to the NVT and C groups (P 〈 0.01, respectively). Smax at the RVOT (2.7 ± 1.9) was steeper than that at the RVA (1.9 ± 1.2, P 〈 0.05). Inducibility of sustained VT/VF was greater at the RVOT (83.3%) than at the RVA (50.0%, P 〈 0.05). Conclusion: In patients with ventricular arrhythmia, VT/VF is highly inducible under conditions of greater spatial dispersion of ventricular refractoriness and APDR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1540-8167.2004.03569.x
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  • 2
    Electronic Resource
    Electronic Resource
    Knowledge conversion with information technology of Korean companies (2003)
    Bradford : Emerald
    Business process management journal 9 (2003), S. 317-336 
    Details
    ISSN: 1355-2503
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: This research aims at finding out how the efforts of Korean enterprises to convert data and information into knowledge are related to the use of information technology. It also aims to come up with plans to efficiently introduce external knowledge by applying information technology.This research was conducted focusing on the cases of enterprises that are carrying out knowledge management by applying information technology and the result shows that Korean enterprises place high value on the application of information technology in introducing knowledge management. However, the use of information technology is not common to all enterprises in four kinds of knowledge conversion. For an organization to efficiently acquire and apply valuable knowledge, the boundary of an enterprise should be extended, and for this, the enterprise should be changed into an extended knowledge enterprise, which is founded on the trust and compensation of all the interested parties. In an extended knowledge enterprise, its first consideration is to acquire knowledge that can efficiently manage and control the interests of customers, suppliers, public institutions, and competitors that exist in the surroundings and to acquire the core knowledge that can make those people and institutions participate. In addition, the organization should possess knowledge base and information communication technology that can smoothly convert data and information into knowledge, by efficiently connecting them.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/14637150310477911
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  • 3
    Electronic Resource
    Electronic Resource
    Production of Exopolysaccharide pullulan from inulin by a mixed culture of Aureobasidium pullulans and Kluyveromyces fragilis (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 33 (1989), S. 129-133 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260330117
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  • 4
    Electronic Resource
    Electronic Resource
    Fractional precipitation for paclitaxel pre-purification from plant cell cultures of Taxus chinensis (2000)
    Springer
    Biotechnology letters 22 (2000), S. 1753-1756 
    Details
    ISSN: 1573-6776
    Keywords: fractional precipitation ; paclitaxel ; plant cell culture ; pre-purification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Fractional precipitation is a simple and efficient procedure for pre-purification of paclitaxel. The optimal methanol composition in water, paclitaxel content in crude extract, storage temperature, and time were 61.5% (v/v), 0.5% (w/v), 0 °C, and 3 days, respectively. As purity of the paclitaxel in the crude extract increases, the purity and yield of paclitaxel from fractional precipitation increases. This pre-purification process serves to minimize the solvent usage, size and complexity of the HPLC operations for paclitaxel purification. This process is readily scalable to a pilot plant and eventually to a production environment where multikilogram quantities of material are expected to be produced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005642001815
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  • 5
    Electronic Resource
    Electronic Resource
    Intermittent maltose feeding enhances paclitaxel production in suspension culture of Taxus chinensis cells (2000)
    Springer
    Biotechnology letters 22 (2000), S. 1793-1796 
    Details
    ISSN: 1573-6776
    Keywords: intermittent feeding ; maltose ; paclitaxel ; Taxus chinensis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract High paclitaxel production (26 mg l−1) was achieved through the intermittent feeding of 3, 1, and 2% (w/v) sucrose at days 0, 7, and 21, respectively, to a suspension culture of Taxus chinensis cells. Intermittent feedings of 1 and 2% (w/v) maltose at days 7 and 21, respectively, to the culture increased the paclitaxel production up to 67 mg l−1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005658405449
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  • 6
    Electronic Resource
    Electronic Resource
    Production of pullulan by a fed-batch fermentation (1987)
    Springer
    Biotechnology letters 9 (1987), S. 621-624 
    Details
    ISSN: 1573-6776
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary In pullulan production from sucrose byAureobasidium pullulans, a sugar concentration higher than 5% (w/v) inhibited cell growth and the production of exopolysaccharide. By a fed-batch fermentation, the inhibitory effects of the high sugar concentration were overcome and 58.0 g/1 of exopolysaccharide were obtained from 10% sucrose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01033198
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  • 7
    Electronic Resource
    Electronic Resource
    Characterization and cDNA cloning of two glycine- and histidine-rich antimicrobial peptides from the roots of shepherd's purse, Capsella bursa-pastoris (2000)
    Springer
    Plant molecular biology 44 (2000), S. 187-197 
    Details
    ISSN: 1573-5028
    Keywords: antimicrobial peptide ; Capsella bursa-pastoris ; glycine-rich peptide ; histidine-rich peptide ; shepherd's purse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Two novel antimicrobial peptides were isolated and characterized from the roots of shepherd's purse, Capsella bursa-pastoris. These antimicrobial peptides, named shepherin I and shepherin II, consist of 28 and 38 amino acids, respectively, and are glycine- and histidine-rich peptides. Shepherin I and shepherin II have 67.9% and 65.8% (mol/mol) glycine, respectively, and 28.6% and 21.1% (mol/mol) histidine, respectively. Both shepherins have a Gly-Gly-His motif. These antimicrobial peptides exhibit antimicrobial activity against Gram-negative bacteria and fungi. Circular dichroism spectra of shepherin I and shepherin II showed that shepherin I and shepherin II in 50% trifluoroethanol have 66.7% and 75% random coils, respectively, without any α-helices. cDNA sequence analysis revealed that shepherin I and shepherin II are produced from a single polypeptide, designated shep-GRP, consisting of 120 amino acids; shep-GRP has five distinct domains, an amino-terminal putative signal peptide, a shepherin I, a linker dipeptide, a shepherin II and a carboxy-terminal peptide. Southern blot analysis indicates that the gene encoding shepherins belongs to a low-complexity gene family. Northern blot analysis revealed that transcripts of shep-GRP are present in roots but not in leaves and stems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006431320677
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