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  • 1
    Electronic Resource
    Electronic Resource
    Opioid Control of the In Vitro Release of Cholecystokinin-Like Material from the Rat Substantia Nigra (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 58 (1992), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Possible interactions between Met-enkephalin and cholecystokinin (CCK)-containing neurons in the rat sub-stantia nigra were investigated by looking for the effects of various opioid receptor ligands and inhibitors of enkephalin-degrading enzymes on the K+-evoked overflow of CCK-like material (CCKLM) from substantia nigra slices. The δ-opioid agonists d-Pen2,dPen5-enkephalin (50 μM) and Tyr-D-Thr-Gly-Phe-Leu-Thr (DTLET; 3 μM) enhanced, whereas the n-opioid agonists Tyr-D-Ala-Gly-MePhe-Gly-ol (DAGO; 10 μM) and MePhe3, D-Pro4-morphiceptin (PL 017; 10 μM) decreased, the K+-evoked release of CCKLM. By contrast, the δ-opioid agonist U-50488 H (5 μM) was inactive. The stimulatory effect of DTLET could be prevented by the 5 antagonist ICI-154129 (50 μM but not by the μ antagonist naloxone (1 μM). Conversely, the latter drug, but not ICI-154129, prevented the inhibitory effect of DAGO and PL 017. A significant increase in CCKLM overflow was observed upon tissue supervision with the peptidase inhibitors kelatorphan or bestatin plus thiorphan. This effect probably resulted from the stimulation of δ-opioid receptors by endogenous enkephalins protected from degradation, because it could be prevented by ICI-154129 (50 μM Furthermore, the peptidase inhibitors did not enhance CCKLM release further when S-opioid receptors were stimulated directly by DTLET (3 μM). These data indicate that opioids acting on d and n receptors may exert an opposite influence, i.e., excitatory and inhibitory, respectively, on CCK-containing neurons in the rat substantia nigra. Because CCK has anti-opioid properties, the δ-opioid control of CCKLM release might participate in the central mechanisms of opiate tolerance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1992.tb09344.x
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  • 2
    Electronic Resource
    Electronic Resource
    Stimulation of oxygen consumption at the cytochrome A"3 level inhibits aldosterone biosynthesis from 18-hydroxycorticosterone
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/General Subjects 884 (1986), S. 270-275 
    Details
    ISSN: 0304-4165
    Keywords: (Adrenal) ; 18-Hydroxycorticosterone ; Aldosterone synthesis ; Sterol oxidation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0304-4165(86)90173-X
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  • 3
    Electronic Resource
    Electronic Resource
    Impact on energy metabolism of quantitative and functional cyclosporine-induced damage of kidney mitochondria
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Bioenergetics 936 (1988), S. 325-331 
    Details
    ISSN: 0005-2728
    Keywords: (Rat kidney mitochondria) ; Ciclosporin ; Energy metabolism ; Nephrotoxicity
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2728(88)90008-4
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  • 4
    Electronic Resource
    Electronic Resource
    The final step of aldosterone biosynthesis requires reducing power - It is not a dehydrogenation
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism 752 (1983), S. 73-78 
    Details
    ISSN: 0005-2760
    Keywords: Aldoslerone synthesis ; Sterol oxidation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2760(83)90234-5
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  • 5
    Electronic Resource
    Electronic Resource
    Cicletanine does not affect plasma atrial natriuretic peptide concentration in healthy subjects (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 593-594 
    Details
    ISSN: 1432-1041
    Keywords: Cicletanine ; (ANP) atrial natriuretic peptide ; plasma cyclic GMP ; antidiuretic hormone ; exercise
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of 50 and 150 mg cicletanine, a new vasodilator antihypertensive, on plasma atrial natriuretic peptide (ANP), cyclic GMP and antidiuretic hormone has been investigated at rest and during standardized exercise, in a double blind cross over study in healthy subjects. Exercise significantly increased the plasma ANP, cyclic GMP and antidiuretic hormone concentrations, and cicletanine did not affect any of them either at rest or during exercise. Since the alpha-1 adrenoceptor blocker prazosine decreases, beta-adrenoceptor blockers increase and the vasodilator cicletanine does not alter the plasma ANP response to exercise, it is suggested that adrenergic receptors may be directly involved in the regulation of ANP secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316103
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  • 6
    Electronic Resource
    Electronic Resource
    Beta-adrenoceptor blockade potentiates exercise-induced release of atrial natriuretic peptide (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. 363-366 
    Details
    ISSN: 1432-1041
    Keywords: atrial natriuretic peptide ; tertatolol ; atenolol ; beta-adrenoceptor blockade ; physical exercise ; aldosterone ; ADH ; cGMP ; PRA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of a non selective and a cardio-selective beta-blocker on basal and exercise-stimulated plasma atrial natriuretic peptide concentrations in healthy volunteers has been studied. Nine healthy volunteers received single oral doses of 5 mg tertatolol, 100 mg atenolol or placebo, at one week intervals, in a double blind cross over trial. At rest plasma atrial natriuretic peptide, aldosterone, antidiuretic hormone and cyclic GMP concentrations and plasma renin activity were not modified by the treatments. During exercise plasma atrial natriuretic peptide concentrations were significantly increased by each treatment, the increment being significantly greater on beta-blockers than on placebo. The rise in atrial natriuretic peptide was 72% after placebo (from 24 to 42 pg/ml), 184% after atenolol (from 30 to 86 pg/ml), and 183% after tertatolol (from 34 to 95 pg/ml), respectively. Thus, the study has shown that in healthy subjects the plasma natriuretic peptide concentration is increased by exercise and that the increase is considerably and equally potentiated by selective and non selective beta-adrenoceptor blockade. The effect may be mainly due to a reduction in ventricular contractility with an increase in atrial pressure. The beta-blockers did not influence the resting plasma atrial natriuretic peptide levels, which suggests that in healthy subjects basal atrial natriuretic peptide secretion is not controlled via beta-receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315576
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  • 7
    Electronic Resource
    Electronic Resource
    Atrial natriuretic factor in patients with acromegaly (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. 409-413 
    Details
    ISSN: 1432-1041
    Keywords: atrial natriuretic factor (ANF) ; acromegaly ; volume expansion ; plasma levels ; extracellular fluid volume ; saline load
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In acromegaly the plasma volume is chronically elevated and it returns to normal when the disease is successfully treated. To define the role of ANF in such a chronic disorder of extracellular fluid volume homeostasis the plasma level was assayed in 37 acromegalic patients with active or inactive (successfully treated) disease. Five patients were studied before and after therapy. The effects of acute change in sodium-fluid status on plasma ANF levels was examined in 7 active and 4 inactive acromegalic patients and in 7 healthy subjects. As compared to 14 patients with inactive acromegaly, 23 patients with active acromegaly had an expanded plasma volume (n=12; 50.1 vs 37.6 ml · kg−1 BW) and an increased blood concentration of growth hormone (n=23; 22.5 vs 2.1 ng · ml−1). Plasma ANF concentrations in active and inactive acromegalic patients (33.2 and 26.6 pg · ml−1, respectively) did not differ significantly from one another or from the level in the controls (26.9 pg · ml−1). In those patients there was no correlation between plasma volume and ANF level. Infusion of 21 isotonic saline in 2 h led to a similar, significant increase in ANF levels in active (from 26.2 to 72.4 pg · ml−1) and in inactive acromegalic patients (from 33.6 to 96.7 pg · ml−1) as well as in healthy subjects (from 21 to 70.6 pg · ml−1). Successful treatment reduced the plasma volume (from 49.2 to 35.8 ml · kg−1 BW) and growth hormone level (from 10.1 to 2.6 pg · ml−1), while the ANF level remained unchanged (from 33.8 to 35.5 pg · ml−1). In the patients with active or inactive acromegaly and cardiac failure the plasma ANF level was markedly increased (89.9 and 66.1 pg · ml−1, respectively) as compared to all the other groups. It is concluded that ANF levels are not elevated in chronically volume expanded acromegalic patients. In the present patients ANF was released in response to acute volume expansion, therefore it may be important in the cardiovascular and renal response to acute changes in extracellular fluid volume.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02336675
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  • 8
    Electronic Resource
    Electronic Resource
    Atrial natriuretic peptide level and intracardiac pressure in cardiac transplant recipients (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. 219-221 
    Details
    ISSN: 1432-1041
    Keywords: Atrial natriuretic peptide ; Cardiac transplant recipients ; Intra cardiac pressures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Blood pressures and plasma atrial natriuretic peptide (ANP) concentrations have been measured in venous and intracardiac sites in 11 patients (10 men and 1 woman) given cardiac transplants. The mean plasma ANP level was 214.4 pg·ml−1 in the superior veina cava and 281 pg·ml−1 in the right atrium. This significantly higher level was maintained in the right ventricle (269) and in the pulmonary artery (295). The level in controls was 25 pg·ml−1. Intra cardiac and mean arterial pressures were in normal range in all patients, and there was no correlation between plasma ANP level and intracardiac pressure. The data suggest that in cardiac transplant patients right atrial pressure does not have a primary role in releasing ANP. The transplanted heart is denervated and remains so for many months after operation, thus suggesting that innervation is not obligatory for ANP secretion. Further studies are required to determine the relative contribution of donor and recipient atrial tissues to ANP secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315019
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  • 9
    Electronic Resource
    Electronic Resource
    Activité antityrosinasique du sérum des malades atteints de mélanome malin; étude à l'aide de l'appareil de Warburg (1964)
    Springer
    Archives of dermatological research 219 (1964), S. 784-789 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung 1. Bereits 1954 konnten wir mit radioaktivem Tyrosin die Antityrosinase-Aktivität des normalen Serums — und mit beträchtlich erhöhtem Titer — diejenige des Serums von Melanom-Kranken nachweisen. 2. Auf viel einfachere Weise, mit Hilfe des Warburgschen Apparates, haben wir beim normalen Serum nachgewiesen, daß a) das normale Serum die Autooxydation der Dopa hemmt oder aufhebt, b) das normale Serum in einer viel sichtbareren Weise die enzymatische Oxydation der Dopa, und besonders die enzymatische Oxydation der Tyrosine, hemmt. 3. Dieser Inhibitor ist dialysabel und an Proteine gebunden. 4. Das Serum von Kranken, die große flächenhafte Epitheliomata anfweisen, oder auch viscerale Krebse haben, besitzt den gleichen Hemmfaktor und zwar, zu einem ähnlichen Titer wie beim Serum des Normalen Menschen. 5. Hingegen besitzt das Serum von Kranken, die ein malignes Melanom aufweisen (14 untersuchte Fälle), den gleichen Hemmfaktor, aber zu einem viel höheren Titer als beim Serum des normalen Menschen oderbei Krebskranken, die an anderen Tumoren erkrankt sind, als an Melanomen. 6. Diese Antityrosin-Aktivität des Serums folgt gewissermaßen der Entwicklung des Melanoms: sie nimmt zu, wenn Metastasen auftreten und im Moment von Rückfällen; sie nimmt ab, wenn man das Melanom entfernen kann. 7. Das genaue Wesen dieses Faktors kennt man noch nicht, es muß erforscht werden und immunoelektrophoretische Untersuchungen. Ich stehe im Begriffe diese Arbeiten durchzuführen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00522956
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  • 10
    Electronic Resource
    Electronic Resource
    Methane conversion by an air microwave plasma (1995)
    Springer
    Plasma chemistry and plasma processing 15 (1995), S. 87-107 
    Details
    ISSN: 1572-8986
    Keywords: Air microwave plasma ; methane activation ; C2 hydrocarbon formation ; carbon monoxide formation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Technology
    Notes: Abstract Activation of methane is carried out by means of an air microwave plasma (2.45 GHz). The experiments cover the absorbed microwave power range 350–650 W (20–50 W cm3 with 17–62%, of methane in the gas mixture, with pressures of 10–66 mbar and flow rates of 140‐700 ml min1. Methane, dioxygen, and dinitrogen consumptions as well as C2 hydrocarbons, carbon monoxide, and dihydrogen yields are analyzed hr gas chromatography. The distance of methane addition from the end of the discharge plays an important role in the composition and the concentration of the products obtained. This distance mainly determines the energy concentrated in the active species of the plasma when they react with methane. A kinetic mechanism jar the activation and decay of inethane and for the formation of C2 hydrocarbons and carbon monoxide is discussed based on the experimental results and kinetic data in the literature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01596683
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