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  • 1
    Electronic Resource
    Electronic Resource
    Failure of dieldrin to affect color vision in juvenile mallard ducks (1973)
    Springer
    Archives of environmental contamination and toxicology 1 (1973), S. 303-311 
    Details
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract Nine mallard ducks were raised artificially from eggs and fed the same long-term doses of dieldrin as their parents (0, 4, or 10 ppm); in addition, three ducks from 10 ppm parents were raised on 50 ppm. The parents had been on dieldrin-treated feed for two years. The juvenile ducks were tested at approximately two months of age. Each duck was trained to respond (key peck) differentially to light wavelengths of 552 mµ (S+) and 610 mµ (S−) and, subsequently, was presented 13 different wavelengths, in random order. Differential responding was analyzed for stimulus generalization. No significant differences (p〈.05) were found between the control and treated groups' mean stimulus generalization gradients. Only the group receiving 50 ppm in their feed had a mean whole-brain dieldrin residue significantly larger (p〈.05) than that of the control group. These results indicate that the ingestion of dieldrin, under the test conditions used, does not have a measurable effect on light wavelength discrimination in mallard ducks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01985432
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  • 2
    Electronic Resource
    Electronic Resource
    Geotraverses across the Swiss Alps (1989)
    [s.l.] : Nature Publishing Group
    Nature 340 (1989), S. 544-548 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Between 1986 and 1988, three major reflection traverses across the Alps were recorded (Fig. 1) for the NFP20 research pro-gramme1"4. They are linked together by two new refraction profiles measured using very close station spacing, parallel to the strike of the Alps. With CROP-Italia, additional ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/340544a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Regulation of MHC class I heterodimer stability and interaction with TAP by tapasin (1997)
    Springer
    Immunogenetics 46 (1997), S. 477-483 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  Major histocompatibility complex (MHC) class I molecules are heterodimers of a class I heavy chain and β2-microglobulin that bind peptides supplied by the MHC region-encoded transporters associated with antigen processing (TAP). Peptide binding by class I heterodimers is necessary for their maturation into stable complexes and is dependent on their physical association with TAP. In human mutant 721.220 cells, however, a novel genetic defect causes the failure of class I heterodimers to associate with TAP. This deficiency correlates with lack of expression of a glycoprotein, tapasin (TAP-associated glycoprotein), which has been found in association with class I heterodimers and TAP. Employing a transcomplementation analysis, we obtained evidence co-localizing the genetic defect of mutant 220 cells and the structural or a regulatory gene controlling the expression of tapasin on the short arm of chromosome 6, which includes the MHC. Expression of tapasin and the normal interaction of class I heterodimers with TAP are concomitantly restored, indicating the probable function of tapasin as a physical link between these complexes. In further support of this model, the absence of tapasin in mutant 220 cells correlates with reduced class I heterodimer stability, suggesting that tapasin may stabilize class I heterodimers and thereby enhance their association with TAP. These results further implicate tapasin in a mechanism that promotes peptide binding by class I heterodimers through their interaction with TAP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050308
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  • 4
    Electronic Resource
    Electronic Resource
    Stimulation of renin secretion by potassium-channel activation with cromakalim (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 443-447 
    Details
    ISSN: 1432-1041
    Keywords: cromakalim ; renin release ; juxtaglomerular cells ; membrane potential ; hyperpolarisation ; potassium channels ; angiotensin II ; norepinephrine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The cardiovascular and endocrine profile of cromakalim has been studied in 8 healthy men (age 25±2 years; X SEM) and its influence on renin release from cultured rat juxtaglomerular cells in vitro has also been examined. According to a double-blind, randomized sequence the subjects received placebo or cromakalim 1 mg as a single daily oral dose for 5 days. Compared to placebo, cromakalim significantly increased plasma renin activity (+122%; from 1.73 to 3.87 ng AI·ml−1·h−1), angiotensin II (+105%; from 5.1 to 10.5 pg·ml−1), and norepinephrine (+61%) levels, and heart rate (+8%). Plasma aldosterone, blood pressure and indices of the electrolyte-fluid volume state were unchanged. Cromakalim in vitro stimulated renin release, from 9.9 to 36.5 ng AI·h−1·30 min·mg cell protein, from juxtaglomerular cells. It appears that the presumed K+-channel activator cromakalim increases renin release in vivo at least in part by direct stimulation of renal juxtaglomerular cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558067
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  • 5
    Electronic Resource
    Electronic Resource
    Nephropathia Epidemica and Puumala Virus in Austria (1999)
    Springer
    European journal of clinical microbiology & infectious diseases 18 (1999), S. 467-472 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  To study the epidemiology of hantavirus infections in Austria, 1215 humans and 596 rodents of different species were tested for the presence of antibodies against Puumala and Hantaan virus. Direct virus identification by polymerase chain reaction in lung tissue of serologically positive rodents was performed to verify antibody results and to determine the genetic identity of viral RNA by phylogenetic analysis of a part of the hantavirus M segment. For 32 of the 37 cases of nephropathia epidemica diagnosed in Austria, the location where transmission took place could be traced to specific areas in the Austrian federal states of Carinthia and Styria. The overall seroprevalence in humans was 1.2% and ranged from 0.02% in Villach, Carinthia, to 0.8% in Korneuburg, Lower Austria, and 1.8% in Wolfsberg, Carinthia. Virus RNA could be amplified from three Clethrionomys glareolus voles collected in Klippitztörl, Carinthia, and from one collected in Ernstbrunn, Lower Austria. The sequences were all identified as Puumala virus by phylogenetic analysis and were found to be most closely related to the western European Puumala viruses from Germany and France. No evidence of the existence of Hantaan-like infections and viruses in Austria was found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100960050325
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