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  • 1
    Electronic Resource
    Electronic Resource
    Connective matrix organization in chronic granulomas of experimental paracoccidioidomycosis (1988)
    Springer
    Mycopathologia 103 (1988), S. 11-20 
    Details
    ISSN: 1573-0832
    Keywords: collagen ; extracellular matrix ; fibroblast ; granuloma ; paracoccidioides brasiliensis ; paracoccidioidomycosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The histological and ultrastructural aspects of chronic granulomas from rats infected intraperitoneally with Paracoccidioides brasiliensis are described with special emphasis on the composition of the extracellular matrix. The granulomas were structurally arranged in two zones, one central containing fungi, and the other peripheral. The extracellular matrix was composed of collagen types I and III, proteoglycans, glycoprotein, and an undefined amorphous substance. The main cellular population was represented by macrophages, epithelioid cells, and giant cells in the central zone, and fibroblasts in the peripheral zone. The fibrotic process was a critical event in this stage of the infection, and showed a centrifugal direction. This might be provoked by direct stimulus from the fungi or by macrophage-fibroblastic interaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00437216
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Histopathological criteria for the diagnosis of abdominal angiostrongyliasis (1991)
    Springer
    Parasitology research 77 (1991), S. 606-611 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract An increasing number of cases of abdominal angiostrongyliasis have recently been diagnosed in southern Brazil. A comparative study of 19 confirmed cases and 15 suspected cases was undertaken to review the anatomo-pathology of the disease and to establish histopathological criteria for its diagnosis. The results were similar in both groups, except for the identification of the worm in the confirmed cases. Macroscopic features comprised two types: a predominant thickening of the intestinal wall (pseudo-neoplasic pattern) and a congestive necrotic lesion (ischemic-congestive pattern). Microscopically, three fundamental histopathological findings were detected: (1) a massive infiltration of eosinophils in a'l layers of the intestinal wall, (2) a granulomatous reaction and (3) eosinophilic vasculitis affecting arteries, veins, lymphatics and capillaries. We conclude that observation of this histopathological triplet excludes other causes of “eosinophilic gastroentertis” and establishes the diagnosis of probable abdominal angiostrongyliasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00931023
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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