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  • 1
    Electronic Resource
    Electronic Resource
    Unilateral internuclear gene transfer and cell differentiation in Schizophyllum (1981)
    [s.l.] : Nature Publishing Group
    Nature 291 (1981), S. 342-344 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] S. commune grows as a dikaryon, cells with two compatible haploid nuclei, and genetic techniques have been well developed such that the two nuclei can be marked with a variety of gene mutations of known linkage relationships8. Eventually, cell differentiation occurs in various areas of the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/291342a0
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  • 2
    Electronic Resource
    Electronic Resource
    Conservation of structure and function of the aflatoxin regulatory gene aflR from Aspergillus nidulans and A. flavus (1996)
    Springer
    Current genetics 29 (1996), S. 549-555 
    Details
    ISSN: 1432-0983
    Keywords: Key words aflR ; Aflatoxin ; Secondary metabolism ; Zinc binuclear cluster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Under limiting growth conditions, Aspergillus nidulans produces a carcinogenic secondary metabolite related to aflatoxin and called sterigmatocystin (ST). The genes for ST biosynthesis are co-ordinately regulated and are all found within an approximately 60-kilobase segment of DNA. One of the genes within this region is predicted to encode a CX2CX6CX6CX2CX6CX2 zinc binuclear cluster DNA-binding protein that is related to the Aspergillus flavus and Aspergillus parasiticus aflatoxin regulatory gene aflR. Deletion of the A. nidulans aflR homolog resulted in an inability to induce expression of genes within the ST gene cluster and a loss of ST production. Because A. nidulans aflR mRNA accumulates specifically under conditions that favor ST production we expect that activation of ST biosynthetic genes is determined by A. nidulans aflR. In support of this hypothesis, we demonstrated that induced expression of the A. flavus aflR gene in A. nidulans, under conditions that normally suppress ST gene expression, resulted in activation of genes in the ST biosynthetic pathway. This result demonstrates that AflR function is conserved between Aspergillus spp. and that aflR expression is sufficient to activate genes in the ST pathway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002940050084
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Conservation of structure and function of the aflatoxin regulatory geneaflR fromAspergillus nidulans andA. flavus (1996)
    Springer
    Current genetics 29 (1996), S. 549-555 
    Details
    ISSN: 1432-0983
    Keywords: allR ; Aflatoxin ; Secondary metabolism ; Zinc binuclear cluster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Under limiting growth conditions,Aspergillus nidulans produces a carcinogenic secondary metabolite related to aflatoxin and called sterigmatocystin (ST). The genes for ST biosynthesis are co-ordinately regulated and are all found within an approximately 60-kilobase segment of DNA. One of the genes within this region is predicted to encode a CX2CX6CX6CX2CX6CX2 zinc binuclear cluster DNA-binding protein that is related to theAspergillus flavus andAspergillus parasiticus aflatoxin regulatory geneaflR. Deletion of theA. nidulans aflR homolog resulted in an inability to induce expression of genes within the ST gene cluster and a loss of ST production. BecauseA. nidulans aflR mRNA accumulates specifically under conditions that favor ST production we expect that activation of ST biosynthetic genes is determined byA. nidulans aflR. In support of this hypothesis, we demonstrated that induced expression of theA. flavus aflR gene inA. nidulans, under conditions that normally suppress ST gene expression, resulted in activation of genes in the ST biosynthetic pathway. This result demonstrates that AflR function is conserved betweenAspergillus spp. and thataflR expression is sufficient to activate genes in the ST pathway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02426959
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Monokaryotic fruiting in Schizophyllum commune: Genetic control of the response to mechanical injury (1979)
    Springer
    Molecular genetics and genomics 175 (1979), S. 5-12 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Monokaryotic fruiting is used as a tool to study mushroom development and differentiation in Schizophyllum commune. This paper reports data which further elucidate the genetic control of the monokaryotic fruiting response to mechanical injury. Models relating the various genes implicated in monokaryotic fruiting body production are proposed and evaluated on their ability to explain the observed data. A minimum estimate is made of the number of genes involved in the initiation of monokaryotic fruiting in response to mechanical injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00267849
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  • 5
    Electronic Resource
    Electronic Resource
    Three independent genetic systems that control initiation of a fungal fruiting body (1979)
    Springer
    Molecular genetics and genomics 171 (1979), S. 257-260 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The initiation of monokaryotic fruiting in the basidiomycetous fungus Schizophyllum commune has been observed to occur spontaneously, in response to biochemical substances, and following mechanical injury. The responses to these three stimuli are genetically separable and under polygenic control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00267580
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Uncontrolled growth associated with novel somatic recombination in the fungus Schizophyllum (1994)
    New York, NY : Wiley-Blackwell
    BioEssays 16 (1994), S. 329-334 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: In the bracket mushroom, Schizophyllum commune, a recessive genetic alteration, mnd, causes abnormally hyperplastic three-dimensional mounds of hyphae to rise from the surface of both haploid and dikaryotic mycelia. mnd, although not a genetic block in the fruiting body developmental pathway, is at least partially epistatic to fruiting. Within dikaryons containing both mutant and wild-type nuclei, [mnd + mnd+], a nonreciprocal somatic recombination event can lead to stable conversion of the mnd+ region of the wild-type nucleus to mnd. This transformation to the homoallelic [mnd + mnd] condition involves no genomic areas other than the mnd region and permanently prevents any further fruiting. Studies relating to the recombination mechanism have ruled out a diploid intermediate state and other concomitants of orthodox somatic recombination, as well as whole chromosome transfer. Instead, a novel form of internuclear genetic transfer is postulated whereby a nearby locus, mob+, controls the mobilization of the mnd chromosomal region alone from one nucleus to the other within the binucleate cells of dikaryotic mycelia.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950160507
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