ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
In order to elucidate the structure of natural polymyxin B1 the cyclic decapeptide 8 γ(V, Fig. 3, with 8 amino acids in the ring and the side chain attached in γ-position) has been synthesized. This is one of the four possible structures deduced for the natural product by the usual degradation methods. The cyclic decapeptide 8 γ appears not to be identical with polymyxin B1 in view of its reduced antibacterial activity and different optical rotatory power.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19600430638
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