ISSN:
1432-1998
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The local cerebral vascular response to hyperventilation vas investigated in five distressed, intubated infants by means of a T2* sensitive gradient-echo MRI technique at 1.5 T. In one preterm infant, the MR signal change during hyperventilation was sparse. In four term infants, the mean MR signal of the brain slice investigated decreased by 1.2–2.6% per kPa change inPCO2 as a reflection of decreased cerebral blood flow during hyperventilation. Pixel-wise analysis revealed absence of vascular response in the basal ganglia, the thalamus or in the occipital region. In two adult controls, who hyperventilated voluntarily, the vascular reactivity was homogeneously distributed predominantly over the grey matter. The experiments demonstrate that local impairment of vascular CO2 reactivity in the distressed infant brain can be detected by T2* sensitive gradient-echo MRI, which is also known as functional MRI.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02019053
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