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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Bioprocess and biosystems engineering 15 (1996), S. 145-150 
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract A new simple strategy for a reliable and robust automatic control of the specific growth rate in fed-batch cultivation processes is presented. Its advantages over model supported control is that the algorithm only needs a minimum of information about the process. Moreover, it is independent of the specific microorganism, the cultivation phase and the biomass level. Also, only a minimum of soft- and hardware is required. Hence, the approach is attractive for industrial production processes that do not have specialized instrumentation. Its accuracy is comparable with model supported control and thus sufficient for most industrial applications. Simulations and experimental tests of the technique performed for the example of a fed-batch cultivation of E. coli demonstrate a good controller performance for various cultivation conditions and process disturbances. Preferred applications will be production systems where the productivity is critically dependent on the growth rate, e.g. in recombinant protein or antibiotic productions.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-6784
    Keywords: fed-batch cultivation ; recombinant protein ; E. coli ; model based optimization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract A model-based feed-rate profile optimization problem is discussed for the fed-batch recombinant protein production. Two optimization procedures, an evolutionary programming technique and a simplified method using the dynamic programming concept, are discussed and compared. Modeling as well as experimental results are presented.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 25 (1983), S. 985-990 
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A graphical method is proposed for batch fermentation process optimization. Its objective function is the maximum output of the product when the time of process is fixed or free. The technique of optimization is based on Bellman's dynamic programming concepts and the assumption that the process can be described by mathematical models of generalized structure. An example of the proposed technique's application is presented.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 26 (1984), S. 419-425 
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The implementation of adaptive control for a fed-batch culture in order to maximize the output of product based on a self-adjusting model is discussed in the present work. Optimization methods were applied to the generalized mathematical model of a fed-batch fermentation process to determine control algorithms that could be used for on-line process control. The efficiency of the proposed adaptive algorithms was investigated by simulating a model system. The model of amylotytic enzyme fermentation that was proposed by the authors was taken from a real process. Dynamic modelling has shown that the main problem of realization is connected with the on-line identification of the adaptive model's parameters. To avoid this problem, we have introduced special limitations on the parameters' time variations that increased the convergence of the identification algorithm. The results of the investigation have shown the efficiency of the proposed adaptive algorithms, and the results of this work should be investigated for real process control.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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