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  • 1
    Electronic Resource
    Electronic Resource
    The pathogenesis of large cell transformation in cutaneous T-cell lymphoma is not associated with t(2;5)(p23;q35) chromosomal translocation (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 24 (1997), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In 20%–50% of the advanced cutaneous T-cell lymphomas (CTCL), malignant T cells undergo large cell transformation (LOT). The malignant T cells of LCT in CTCL can share morphologic and immunophenotypic similarities with CD30 (Ki-1)-positive anaplastic large cell lymphoma (ALCL), suggesting a common mechanism of pathogenesis. The t(2;5) (p23;q35) translocation, resulting in the fusion of the nucleophosmin (NPM) gene and the anaplastic lymphoma kinase (ALK) gene, is associated with primary CD30+ ALCL.To determine whether acquisition of this chromosomal translocation is involved in the pathogenesis of LCT in CTCL, we examined 12 tumor samples from 9 CTCL patients, including 8 with LCT-CTCL and one with concurrent CTCL and Hodgkin's disease, for the presence of the t(2;5) translocation. Numerous CD30+ large cells were present in 4 LCT-CTCL consistent with secondary CD30+ ALCL; CD30 was expressed by 〈10% of the large cells in another case and was negative in the other 3 lymphomas. Using primers spanning the NPM/ALK fusion junction, PCR amplification following reverse transcription (RT) of mRNA failed to show the products of NPM/ALK fusion in all samples tested. Thus, the t(2;5) (p23;q35) translocation does not appear to be involved in the molecular pathogenesis of LCT in CTCL, including CD30+ cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1997.tb00814.x
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  • 2
    Electronic Resource
    Electronic Resource
    Ancient Chinese anchors: their rigging and conservation (1998)
    Oxford, UK : Blackwell Publishing Ltd
    The @international journal of nautical archaeology 27 (1998), S. 0 
    Details
    ISSN: 1095-9270
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Archaeology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-9270.1998.tb00811.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Production, survival and efficacy of Coniothyrium minitans conidia produced in shaken liquid culture (2003)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 227 (2003), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Coniothyrium minitans is a fungal biocontrol agent of the plant pathogen Sclerotinia sclerotiorum. Growth and sporulation of 21 strains of C. minitans were examined on potato dextrose agar (PDA) and compared with that in potato dextrose broth (PDB) in shaken culture after 12 days at 20°C, to identify strains with potential for inoculum production in liquid culture. Four strains that produced high numbers of pycnidia in PDA also formed pycnidia on mycelial strands in PDB and 107 conidia ml−1 broth were produced. The other strains formed pellets during shaking, resulting in production of less than 105 conidia ml−1. Conidia from shaken PDB culture had the same ability to infect and rot sclerotia of S. sclerotiorum as conidia produced routinely on PDA, and survived well in dry kaolin dust for 6 months at temperatures less than 8°C with less than 1 log10 colony forming units mg−1 loss. These results suggest that it might be possible to identify useful strains of C. minitans for future commercial conidial production in liquid fermentation systems based on morphological characteristics on agar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0378-1097(03)00666-9
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  • 4
    Electronic Resource
    Electronic Resource
    The phenylalanine ammonia-lyase gene family in Arabidopsis thaliana (1995)
    Springer
    Plant molecular biology 27 (1995), S. 327-338 
    Details
    ISSN: 1573-5028
    Keywords: gene expression ; multi-gene family ; phenylalanine ammonia-lyase ; phenylpropanoids ; promoters ; secondary metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Phenylpropanoid derivatives are a complex class of secondary metabolites that have many important roles in plants during normal growth and in responses to environmental stress. Phenylalanine ammonialyase (PAL) catalyzes the first step in the biosynthesis of phenylpropanoids, and is usually encoded by a multi-gene family. Genomic clones for three Arabidopsis thaliana PAL genes containing the entire protein-coding region and upstream and downstream sequences have been obtained and completely sequenced. Two A. thaliana PAL genes (PAL1 and PAL2) are structurally similar to PAL genes that have been cloned from other plant species, with a single intron at a conserved position, and a long highly conserved second exon. Previously identified promoter motifs plus several additional sequence motifs were found in the promoter regions of PAL1 and PAL2. Expression of PAL1 and PAL2 is both qualitatively and quantitatively similar in different plant organs and under various inductive conditions. A third A. thaliana PAL gene, PAL3, differs significantly from PAL1 and PAL2 and other sequenced plant PAL genes. PAL3 contains an additional intron, and its deduced amino acid sequence is less homologous to other PAL proteins. The PAL3 promoter region lacks several sequence motifs conserved between A. thaliana PAL1 and PAL2, as well as motifs described in other genes involved in phenylpropanoid metabolism. A. thaliana PAL3 was expressed at very low levels under the conditions examined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00020187
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