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  • 1
    Electronic Resource
    Electronic Resource
    Laboratory measurements of pivoting angles for applications to selective entrainment of gravel in a current (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 33 (1986), S. 0 
    Details
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Important to grain entrainment by a flowing fluid is the pivoting angle of the grain about its contact point with an underlying grain. A series of experiments has been undertaken to determine how this angle depends on grain shape (rollability and angularity), on the ratio of the size of the pivoting grain to those beneath, and on factors such as imbrication. The experiments involved gravel-sized spheres (ball-bearings and marbles), natural pebbles selected for their approximately triaxial ellipsoid shapes, and angular crushed basalt pebbles. The pivoting angles for these grains were measured on an apparatus consisting of a board which can be progressively inclined, the angle of the board being equal to the pivoting angle at the instant of grain movement.The pivoting angles of spheres showed reasonable agreement with a theoretically derived equation, showing much better agreement than in previous studies which utilized sand-sized spheres. A series of measurements with spheres ranging from sand to gravel sizes reveals that the pivoting angles decrease with increasing particle size. Our results are therefore consistent with the earlier studies limited to sand-size spheres. The cause of this size dependence is unknown since moisture and electrostatic binding can be ruled out. Similar size dependencies are also found for the ellipsoidal pebbles and angular gravel.The experiments with ellipsoidal pebbles demonstrated a strong shape dependence for the pivoting angle, being a function of the ratio of the pebble's smallest to intermediate axial diameters. This ratio controls the grain's ability to roll and pivot; with small ratios of these diameters the pebbles tended to slide out of position, whereas with ratios closer to unity (circular cross-section) true pivoting took place and the angles were smaller. Experiments with flat pebbles placed in an imbricated arrangement yielded much larger angles than when the pebbles lay in a horizontal position, the pivoting angle being increased approximately by the imbrication angle. The angular crushed gravel also required high pivoting angles, apparently due to interlocking of the grains resulting from their angularity.Other factors being equal, the measurements of pivoting angles demonstrate that the order of increasing difficulty of entrainment is spheres, ellipsoidal grains, angular grains, and imbricated grains. The results obtained here make possible the quantitative evaluation of these shape effects on grain threshold, as well as evaluation of the selective entrainment of grains from a bed of mixed sizes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3091.1986.tb00545.x
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  • 2
    Electronic Resource
    Electronic Resource
    Pivoting analyses of the selective entrainment of sediments by shape and size with application to gravel threshold (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 33 (1986), S. 0 
    Details
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Measured variations of pivoting angles with grain size, shape (‘reliability’ and angularity) and imbrication are employed in analyses of grain threshold to examine how these factors influence selective grain entrainment and sorting. With a bed of uniform grain sizes, as employed experimentally to establish the standard threshold curves such as that of Shields, the threshold condition depends on grain shape and fabric. The analysis demonstrates quantitatively that there should be a series of nearly-parallel threshold curves depending on grain pivoting angles. For a given grain size, the order of increasing flow strength required for entrainment is spheres, smooth ellipsoids (depending on their ‘reliability’), angular grains, and imbricated ellipsoids (depending on their imbrication angles). The relative threshold values for these different grain shapes and fabric are predicted according to their respective pivoting angles, but remain to be directly tested by actual threshold measurements.The pivoting angle of a grain also depends on the ratio of its size to those it rests upon. This dependence permits an evaluation of selective entrainment by size of grains from a bed of mixed sizes, the condition generally found in natural sediments. The pivoting model predicts systematic departures from the standard threshold curves for uniform grain sizes. Such departures have been found in recent studies of gravel threshold in rivers and offshore tidal currents. The pivoting model is compared with those threshold data with reasonable agreement. However, more controlled measurements are required for a satisfactory test of the model.It is concluded that variations in pivoting angles for grain entrainment are significant to the processes of selective sorting by grain size and shape.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3091.1986.tb00546.x
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  • 3
    Electronic Resource
    Electronic Resource
    Applications of grain-pivoting and sliding analyses to selective entrapment of gravel and to flow-competence evaluations (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 35 (1988), S. 0 
    Details
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Models of sediment threshold by grain pivoting or sliding over underlying particles are examined in order to explore their application to evaluations of selective entrainment of gravel by flowing water. Of special interest is whether such process-based models provide satisfactory evaluations of flow competence and the movement of large clasts by floods. A detailed derivation is undertaken, focusing first on the fluid flow and forces at the particle level. The resulting threshold equation for the particle-level velocity is then modified to yield the mean entrainment stress for the flow as a whole. This approach is appropriate for considerations of selective entrainment of grains of varying sizes within a deposit, the sorting being due to their relative projection distances above the bed and the dependence of their pivoting angles on grain size and shape. The resulting threshold equations contain a number of coefficients (e.g. drag and lift) whose values are poorly known, but can be constrained by requiring agreement with the Shields curve for the threshold of grains in uniform deposits. If pivoting coefficients based on laboratory measurements with tetrahedral arrangements of particles are used in the models, smaller degrees of selective sorting are predicted than found in the field measurements of gravel entrainment. However, if reasonable modifications of those coefficients are made for expected field conditions, then the models yield good agreement with the data. Sliding models, where sorting is due entirely to projection distances of the grains above the bed, yield somewhat poorer agreement with the field data; however, the sliding models may have support from laboratory experiments on gravel entrainment in that the data and theoretical curves have similar concave trends. The existing measurements lack documentation of the mechanisms of grain movement, so it is not possible to conclusively determine the relative importance of grain pivoting versus sliding. In spite of such uncertainties, the results are encouraging and it is concluded that pivoting and sliding models for grain entrainment do have potential for field computations of selective entrainment and flow competence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3091.1988.tb01244.x
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  • 4
    Electronic Resource
    Electronic Resource
    A missense mutation in the αB-crystallin chaperone gene causes a desmin-related myopathy (1998)
    [s.l.] : Nature America Inc.
    Nature genetics 20 (1998), S. 92-95 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Desmin-related myopathies (DRM) are inherited neuromuscular disorders characterized by adult onset and delayed accumulation of aggregates of desmin, a protein belonging to the type III intermediate filament family, in the sarcoplasma of skeletal and cardiac muscles. In this paper, we have mapped ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1765
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  • 5
    Electronic Resource
    Electronic Resource
    Human desmin gene: cDNA sequence, regional localization and exclusion of the locus in a familial desmin-related myopathy (1996)
    Springer
    Human genetics 〈Berlin〉 98 (1996), S. 422-429 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Desmin is a muscle-specific intermediate filament that is encoded by a gene assigned to human chromosome 2q35. Desmin-related myopathies are inherited disorders characterized by an intrasarcoplasmic accumulation of desmin. Recently, the knockout of the desmin gene was shown to generate a myopathic syndrome in transgenic mice, suggesting that functional abnormality of desmin may generate similar clinical symptoms in mouse and human. To determine the potential role of the desmin gene in a well-defined desmin-related myopathy (autosomal dominant form of Fardeau), human desmin cDNAs obtained from affected and unaffected individuals were cloned, sequenced and compared. No obvious mutation was detected. A BssHII restriction fragment length polymorphism (RFLP) was identified in exon 6 of the desmin gene. This RFLP was associated with a previously identified EcoRV RFLP in exon 4 to generate a tetra-allelic system, which was tested for linkage to the desmin-related myopathy in three families. The human desmin gene was localized within an 11-cM interval on chromosome 2q using a panel of radiation hybrids. This 11-cM region was clearly excluded by linkage analysis in the three desmin-related myopathy families using a set of highly polymorphic microsatellite markers. These results suggest that the desmin gene is not primarily involved in this disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050233
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  • 6
    Electronic Resource
    Electronic Resource
    Migration of myogenic cells from the somites to the fore-limb buds of developing mouse embryos (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Developmental Dynamics 203 (1995), S. 324-336 
    Details
    ISSN: 1058-8388
    Keywords: Somites ; Limb bud ; Myogenic cells ; Transgenic embryos ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: In this study, we have isolated newly formed somites from the caudal regions of 8.5 day mouse embryos and transplanted them orthotopically into correspondingly staged hosts at the level of the prospective limb-forming region. The experimental embryos were then cultured intact for 32-36 hr. The donor somites used were pre-labelled with DiI, a fluorescent lipophilic dye, or were obtained from transgenic embryos that carried a 1 kb 5′ regulatory sequence of the desmin gene linked to the gene encoding Escherichia coli β-galactosidase. The transgene is specifically expressed in skeletal muscles (Li et al. [1993] Development 117:947-959). The aim of these experiments was to show definitively that the musculature of the mammalian limb is derived from the somites. The results demonstrated that DiI-labelled cells from the implanted somites were able to invade the proximal region of the fore-limb bud during the course of development. The use of transgenic somites as grafts confirmed that some of the somitic cells found in the limbs were myogenic cells. To determine whether the displacement of somitic cells is an active or passive process, somatopleure obtained from the prospective limb-forming regions of day 8.5 day embryos was implanted into 8.5 day hosts. We did not detect the presence of DiI-labelled somatopleural cells in the fore-limb after 32-36 hr of culture. This suggests that somitic cells reached the limb bud via active locaomotion rather than as a result of being passively dragged there, as the limb elongates during development. In addition, we injected latex beads into the somites, as probes, to determine whether extracellular matrix-driven translocation plays a role in driving the somitic cells to the limb bud. In a majority of the specimens examined, we could not detect the presence of these beads in the limb bud. However, in the trunk of these embryos, the beads were found dispersed throughout the ventral neural crest pathway.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1002030305
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