Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Scandinavian journal of immunology
4 (1975), S. 0
ISSN:
1365-3083
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The specificity of cell-mediated lympholysis in the mouse was investigated by studying the cross-reactivity of in vitro-generated effector cells against targets carrying H-2 haplotypes different from that of the stimulator. Congenic resistant partners of the C57BL/10 strain carrying ten different, independently derived haplotypes were tested in more than 600 combinations. Strong cytotoxicity was observed when stimulator and target cells shared a private determinant, but considerable cross-killing was also seen in combinations where stimulator and target cells shared only public determinants. Cross-killing is specific and can be blocked only by unlabeled cells of the stimulator or target strain. Although cross-killing does not correlate with the number of stimulating public determinants carried by the target individual determinants 5, 15. 25, and 27 + 28 + 29 are associated with increased cross-killing. Cross-killing can occur both at the K and the D end of H-2 and is not explained by antigens determined by the I region. We conclude that the serologically defined H-2K and H-2D molecules are the primary targets for cytotoxic T lymphocytes but that they may be perceived differently by T and B lymphocytes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-3083.1975.tb02660.x
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