ISSN:
1432-1041
Schlagwort(e):
dipyrone
;
metabolites
;
excretion in milk
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
,
Medizin
Notizen:
Summary Breast milk and plasma levels of dipyrone metabolites in 8 mothers given a single oral dose of the drug were determined by HPLC. Four metabolites were demonstrated by the analytical method: 4-methylaminoantipyrine (MAA), 4-aminoantipyrine (AA), 4-formylaminoantipyrine (FAA) and 4-acetylaminoantipyrine (AAA). A good correlation was found between the plasma and milk concentrations of the metabolites. The mean (±SD) milk to plasma concentration ratios were: MAA=1.37±0.28, AA=1.15±0.40, FAA=1.03±0.09, AAA=0.97±0.24. The disposition pattern of the dipyrone metabolites in milk was studied in two mothers. None of the metabolites was detectable 48 h after drug administration.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00541545
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