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  • 1
    Electronic Resource
    Electronic Resource
    A method for removal of fibroblasts from human tissue culture systems
    Amsterdam : Elsevier
    Experimental Cell Research 185 (1989), S. 519-528 
    Details
    ISSN: 0014-4827
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-4827(89)90320-0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Fetal Cutaneous Myofibroblasts — Fact or Fallacy? (2005)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: It has been known for several decades that early gestational human fetuses will regenerate cutaneous wounds resulting in a scarless repair. In postnatal humans, myofibroblasts are known to play a central role in wound healing and in the pathology of fibrosis. The role of the profibrotic growth factor TGF-β1 in human fetal fibroblasts remains unclear, with recent data now showing that TGF-β1 is present in fetal wounds but for shorter periods. We have therefore examined the effects of TGF-β1 on fibroblasts isolated from early human fetuses (〈14week EGA). We have identified that stimulation with 5 ng/ml TGF-β1 induces a significant proportion of human fetal fibroblasts to differentiate into myofibroblasts (approximately 40%), as identified by staining of α-smooth muscle actin (n = 5). Interestingly, this response was earlier (peaking at day 2–3) and more transitory (over by day 4–5) than that seen with postnatal dermal fibroblasts (peaking at day 6–8 and dropping at day 10). We examined the effects of blocking various intracellular pathways involved in TGF-β1 signalling. The early and transitory myofibroblast induction seen in fetal cells is blocked by an inhibitor of p-JNK (n = 4; p =〈 0.05). In contrast, the later and more prolonged induction of myofibroblasts seen in postnatal cells was not affected by inhibition of p-JNK. Despite the fact that fetal fibroblasts do indeed differentiate into myofibroblasts they were further shown to exhibit differential behavior to postnatal myofibroblasts with respect to TGF-β1 stimulation of collagen expression, producing significantly less soluble collagen (approximately 50%, n = 4) after 24 or 48 hours of treatment with TGF-β1 in serum-free media. These results appear to indicate a role for TGF-β1 during cutaneous wound healing in the early fetus and show that the response of fetal cells to this important profibrotic cytokine is rapid and more controlled, being short lived. It is possible that a prolonged response to this cytokine may lead to the overblown nature of postnatal wound healing, resulting in fibrosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130117w.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Ruby laser-assisted hair removal – long-term results after repeated treatments (2000)
    Springer
    European journal of plastic surgery 23 (2000), S. 121-126 
    Details
    ISSN: 1435-0130
    Keywords: Key words Ruby laser ; Hair ; Hirsutism ; Selective photothermolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The long-pulsed ruby laser has been used to remove unwanted body hair with encouraging results. It is clear from various studies that complete removal of hair is unlikely after a single treatment and diverse response rates have been observed in various individuals. It was the aim of this study to examine the efficacy of ruby laser hair removal after repeated treatments and to assess the patients’ satisfaction with this method of hair removal. In all, 88 patients were treated with the Chromos 694 Depilation Ruby Laser (SLS/Biophile, Wales) at monthly intervals for 4 months and their hair density was measured at 7 and 12 months after the first treatment. The average reduction in hair density was 13.7% at 1 year, which was statistically significant. No adverse long-term side effects were seen. Although only 44.3% of patients had reduced hair count at 1 year, 79.5% patients were satisfied with their treatment. In conclusion, we have shown in this study that the long-pulsed ruby laser is only effective in permanently removing a small proportion of unwanted dark coloured body hair. This method of hair removal is, however, superior to other conventional types of hair removal according to the patients’ subjective observation, because it slows the hair growth, causes thinning of hair, and provides good temporary control of hair from most treatment sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002380050229
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Ruby laser-assisted hair removal – correlation of efficacy with the growth cycle of human hair (2000)
    Springer
    European journal of plastic surgery 23 (2000), S. 127-131 
    Details
    ISSN: 1435-0130
    Keywords: Key words Ruby laser ; Hair removal ; Hair growth
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  There is great variation in response when ruby laser is used to remove unwanted body hair. Destruction of hair is often not possible after one laser treatment and the frequency and timing of repeated treatments required to achieve optimum treatment results are unknown. It was the aim of this study to determine whether the efficacy of ruby laser hair removal depended on the hair growth cycle. A prospective clinical study was carried out. The lower legs of 48 patients were treated with the Chromos 694 ruby laser at a standard fluence of 11 Jcm–2. Treatment efficacy was determined as the percentage decrease in hair density at 3 and 7 months. The proportion of growing and resting hairs in the treatment site was assessed by examination of plucked hair roots harvested from areas adjacent to the treatment site. To determine whether examination of plucked hair roots microscopically was reliable in assessing the proportion of growing and resting hairs in a specific site, 7 ex-vivo scalp skins were examined histologically. Results showed that examination of plucked hair roots was a reliable method in assessing the proportion of growing and resting hair. There was no correlation between the treatment efficacy and the growth phases of hair (one way analysis of variance, P=0.116). In conclusion, growing hairs are not more susceptible than resting hairs to ruby laser injury. The clinical implications of this finding are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002380050230
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    Paper (German National Licenses)
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