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  • 1
    Electronic Resource
    Electronic Resource
    The nonlinear dynamics of a small lens (1992)
    Springer
    Physical oceanography 3 (1992), S. 163-173 
    Details
    ISSN: 0928-5105
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract A theory for lenses whose geometric and internal deformation radii are comparable is developed. By constraining the lenses to be elliptical, it is possible to treat the nonlinear terms in the hydrodynamic equations in a complete fashion. This means that thes terms are balanced exactly by the local, Coriolis, and hydrostatic head gradient accelerations. Two examples of the dynamical evolution of such a lens are presented. The first considers the motion in the absence of any external flow. The second examines the dynamical response of the lens to large-scale deformation. The principal conclusion of the study is that the inclusion of the nonlinear terms in the dynamical balance induces fluctuations in the internal wave band of the hydrodynamic fields.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02197065
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Measurements of hydrogen peroxide induced premature senescence:senescence-associated β-galactosidase and DNA synthesis index in human diploid fibroblasts with down-regulated p53 or Rb (2000)
    Springer
    Biogerontology 1 (2000), S. 335-339 
    Details
    ISSN: 1573-6768
    Keywords: dose response ; growth arrest ; oxidants ; senescent biomarkers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Human diploid fibroblasts (HDFs) inevitably undergo replicative senescence in culture after serial passages. Recent work indicates that early passage HDFs undergo irreversible growth arrest and develop features of senescence after being treated with oxidants and other agents. Senescence is usually measured by a decrease in DNA synthesis index and an increase in the activity of senescence-associated β-galactosidase (SA β-gal). We compared these two measurements here and found that IMR-90 HDFs lost the ability to synthesize DNA immediately but did not activate SA β-gal until 4 days after the treatment with 75 µM or 0.75 pmol/cell H2O2. Expression of human papillomaviral E6 or/and E7 genes results in reduction of p53 or/and Rb protein levels and increases in ED50 for DNA synthesis inhibition or SA β-gal expression. A small fraction of wild type and E7 expressing cells could not synthesize DNA and did not express SA β-gal one week following the treatment with H2O2 at doses lower than 150 µM or 1.5 pmol/cell. The dose response curve of SA β-gal activation overlapped with that of DNA synthesis inhibition in E6 and E6E7 expressing cells. The results indicate that the expression of SA β-gal correlates with inability of DNA synthesis in the majority of wild type, E6, E7 or E6E7 expressing cells one week after H2O2 treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026590501344
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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