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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    International journal of computer vision 38 (2000), S. 247-265 
    ISSN: 1573-1405
    Keywords: entropy functions ; ensemble equivalence ; FRAME models ; Julesz ensembles ; Kullback-Leibler divergence ; large deviation ; Markov random fields
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract In the past thirty years, research on textures has been pursued along two different lines. The first line of research, pioneered by Julesz (1962, IRE Transactions of Information Theory, IT-8:84–92), seeks essential ingredients in terms of features and statistics in human texture perception. This leads us to a mathematical definition of textures in terms of Julesz ensembles (Zhu et al., IEEE Trans. on PAMI, Vol. 22, No. 6, 2000). A Julesz ensemble is a set of images that share the same value of some basic feature statistics. Images in the Julesz ensemble are defined on a large image lattice (a mathematical idealization being Z 2) so that exact constraint on feature statistics makes sense. The second line of research studies Markov random field (MRF) models that characterize texture patterns on finite (or small) image lattice in a statistical way. This leads us to a general class of MRF models called FRAME (Filter, Random field, And Maximum Entropy) (Zhu et al., Neural Computation, 9:1627–1660). In this article, we bridge the two lines of research by the fundamental principle of equivalence of ensembles in statistical mechanics (Gibbs, 1902, Elementary Principles of Statistical Mechanics. Yale University Press). We show that 1). As the size of the image lattice goes to infinity, a FRAME model concentrates its probability mass uniformly on a corresponding Julesz ensemble. Therefore, the Julesz ensemble characterizes the global statistical property of the FRAME model; 2). For a large image randomly sampled from a Julesz ensemble, any local patch of the image given its environment follows the conditional distribution specified by a corresponding FRAME model. Therefore, the FRAME model describes the local statistical property of the Julesz ensemble, and is an inevitable texture model on finite (or small) lattice if texture perception is decided by feature statistics. The key to derive these results is the large deviation estimate of the volume of (or the number of images in) the Julesz ensemble, which we call the entropy function. Studying the equivalence of ensembles provides deep insights into questions such as the origin of MRF models, typical images of statistical models, and error rates in various texture related vision tasks (Yuille and Coughlan, IEEE Trans. on PAMI, Vol. 2, No. 2, 2000). The second thrust of this paper is to study texture distance based on the texture models of both small and large lattice systems. We attempt to explain the asymmetry phenomenon observed in texture “pop-out” experiments by the asymmetry of Kullback-Leibler divergence. Our results generalize the traditional signal detection theory (Green and Swets, 1988, Signal Detection Theory and Psychophysics, Peninsula Publishing) for distance measures from iid cases to random fields. Our theories are verified by two groups of computer simulation experiments.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of mammary gland biology and neoplasia 2 (1997), S. 365-372 
    ISSN: 1573-7039
    Keywords: Prolactin signaling ; Stat5 ; mammary development ; alveoli ; milk secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The mammary gland is a recent acquisition on the phylogenetic scale of organ evolution and is characterized by an unparalleled regenerative capacity. With each pregnancy an expanded lobulo-alveolar compartment rises on the ductal compartment and differentiates to secrete large amounts of milk during lactation. After weaning of the young the entire alveolar compartment undergoes apoptosis and is remodeled to return to a virgin-like state. Evolution recruited old hands from existing signaling pathways to guide and accomplish the extraordinary task of repeatedly building and destroying this highly specialized tissue. Seventy years ago it was known that the presence of estrogen, progesterone, and prolactin (PRL)3 was essential for ductal and alveolar development. The recent ability to generate mice from which genes have been deleted by homologous recombination has made it possible to gain molecular insight into the signaling pathways used by these hormones to effect mammary differentiation. In the cast of characters progesterone and PRL are on center stage. After binding to its receptor, PRL activates the JAK-STAT pathway leading to transcription of genes which induce alveolar proliferation and differentiation. In vivo experiments have shown that JAK-Stat signaling is mandatory for adult mammary gland development and lactation. Two Stat molecules, Stat3 and Stat5, appear to have opposite functions and their relative activity may serve to control developmental cycles of mammary tissue. While Stat5 activity has been linked to alveolar proliferation and function, Stat3 activity correlates with the loss of alveolar function, cell death and the initiation of mammary tissue remodeling.
    Type of Medium: Electronic Resource
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