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Interaction of the antihypertensive drug felodipine with calmodulin (1981)

Boström, Stig-Lennart ; Ljung, Bengt ; Mårdh, Sven ; [et al.]

[s.l.] : Nature Publishing Group

Nature 292 (1981), S. 777-778

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] The effects of felodipine were studied in the isolated rat portal vein. The smooth muscle of this vessel shows many similarities to that of the haemodynamically important small resistance vessels, including its pronounced dependence on extracellular [Ca2+] (refs 3-5). Figure la shows the ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/292777a0

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Postnatal ontogenic development of the adrenergic innervation pattern in the rat portal vein (1976)

Lundberg, Jan ; Ljung, Bengt ; Stage (Mc Murphy), Dorothy ; [et al.]

Springer

Cell & tissue research 172 (1976), S. 15-27

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ISSN: 1432-0878

Keywords: Portal vein ; Rat ; Adrenergic innervation ; Postnatal ; Ontogenesis ; Histofluorescence

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary The postnatal development of the adrenergic innervation pattern in the rat portal vein has been studied with the histochemical fluorescence method of Hillarp and Falck. Stretch preparations and transverse freeze-dried sections of intact portal veins were studied from rats during the first 5 weeks of life and from adult rats. Orientation of undifferentiated smooth muscle cells into two layers was observed at 4 days of age. Dominance of the thick outer longitudinal muscle layer was apparent at two weeks of age. A terminal adrenergic nerve plexus with some varicosities was restricted outside the media at the end of the first week. Ingrowth of penetrating non-terminal adrenergic nerve fibers through the longitudinal muscle layer occurred during the second week of age when the main terminal nerve plexus was developing between the two muscle layers. After 3 weeks of age the adult pattern of a two-dimensional adrenergic plexus between the muscle was established. In the adult rat pharmacological treatment with nialamide and noradrenaline revealed the thin, penetrating non-terminal adrenergic nerve fibers in the longitudinal muscle layer which were poorly visible otherwise. The present observations strongly indicate that the main adrenergic plexus between the two muscle layers emanates directly from the outer axonal plexus. These findings are discussed regarding possible trophic interactions between ingrowing sympathetic adrenergic vasomotor nerves and maturing vascular smooth muscle.