ISSN:
1432-0800
Source:
Springer Online Journal Archives 1860-2000
Topics:
Energy, Environment Protection, Nuclear Power Engineering
,
Medicine
Notes:
Summary The female Mongolian Gerbil does not appear to be highly sensitive to DMF when compared to other species. Induced liver pathology and changes in body weight were similar irrespective of the route of administration. The toxic response from a single administration, as noted by the LD50, appears to be within the 3,000 to 4,000 mg/kg for IP, SC and intubated quantities. Consumption studies had the following LD50 values for related toxin levels: 66,000 ppm, 3,929 mg/kg in 3 days; 34,000 ppm, 3,846 mg/kg in 6 days; 17,000 ppm, 90,206 mg/kg in 80 days and 10,000 ppm, more than 100,000 mg/kg in more than 200 days. DMF imbibed at 10,000 ppm for 30 days in drinking water failed to cause observable liver, kidney or weight changes. Higher dosage levels of DMF, as reported, did cause death and physiological changes. DMF levels causing loss of weight were also causing serious pathological changes in the liver or kidneys in the form of necrotic foci. This loss of weight was generally associated with acute toxicity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01685306
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