Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Scandinavian journal of immunology
8 (1978), S. 0
ISSN:
1365-3083
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The presence of five isozymes of 5′-nucleotide phosphodiesterase in human sera and the use of the fast-moving isozyme-V as a diagnostic aid for human primary and secondary hepatoma (liver metastasis) have been reported from our laboratories. The present paper describes further work in the use of isozyme ratio for the possible discrimination of the two groups of patients.Tissue enzyme study has defined both IV and V as from liver, and III from colon. The ratios for V/IV and (IV + V)/III were therefore possibly significant for this purpose. Our sampling indicates that for primary hepatoma V/IV = 0.78±0.56 and for liver metastasis V/IV = 0.96±0.57 (p〉0.05). On the other hand (V + IV)/III = 0.76 ±0.52 for primary hepatoma, and (V + IV)/III = 1.12±0.64 for secondary hepatoma (p == 0.05). It is therefore possible to improve the discrimination of secondary hepatoma from primary hepatoma with the aid of isozyme ratio study. Clusters in scatterogram for these groups are discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-3083.1978.tb03979.x
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