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  • 1
    Electronic Resource
    Electronic Resource
    The benzoylarginine peptidase from Treponema denticola (strain ASLM), a human oral spirochaete: evidence for active-site carboxyl groups (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 4 (1990), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The benzoylarginine peptidase of Treponema denticola (strain ASLM; a human oral spirochaete) was progressively and irreversibly inactivated by 1-(ethoxycarbonyl)-2-ethoxy-1, 2-dihydroquinoline, a carboxyl-group reagent. At acidic pH values, reaction of one mole of the modifier per active site of the enzyme resulted in total inactivation of the enzyme. Assuming that this modifier is a specific carboxyl reagent, the data suggest that the inactivation of the T. denticola benzoylarginine peptidase was caused by the modification of one carboxyl group located close to the active site of the enzyme. Results obtained with Woodward's reagent K (N-ethyl-5-phenylisoxazolium 3’-sulphonate) supported these findings. Carbethoxylation with diethylpyrocarbonate effectively inactivated the enzyme, and addition of hydroxylamine at pH 7.0 restored the activity almost totally, suggesting that the pyrocarbonate had reacted with tyrosyl or histidyl residues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1990.tb00721.x
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  • 2
    Electronic Resource
    Electronic Resource
    Estimation of sensitivity and specificity of site-specific diagnostic tests (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 25 (1990), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Clinical trials designed to estimate the sensitivity and specificity of periodontal diagnostic tests often use multiple sites per patient as experimental units of analyses. Since site-specific test results within a patient are dependent observations, a correlated binomial model should be employed to estimate the sensitivity and specificity of these diagnostic tests. Ignoring the within-patient correlation can result in an over- or underestimation of the true standard errors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1990.tb00903.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Metronidazole therapy for periodontitis (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 22 (1987), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1987.tb01574.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Bacterial leakage around dental restorations: its effect on the dental pulp (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 11 (1982), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study revealed that the quantity of bacteria filtered from the base of Class V cavity restorations were directly related to the type of medicament used. Of the brands studied: composite, amalgam, silicate, and guttapercha – each produced varying numbers of bacterial colonies, whereas zinc oxide and eugenol cement showed none. Histopathology of the pulps correlated directly to the microbiological data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1982.tb00188.x
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  • 5
    Electronic Resource
    Electronic Resource
    Rabbit polymorphonuclear leukocyte migration in vitro in response to dental plaque (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 9 (1974), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Human dental plaque extracts in Gey's medium and whole human saliva were tested in the Boyden Chamber system for chemotactic activity against rabbit peritoneal polymorphonuclear leukocytes. Positive controls were a semipurified bacterial chemotactic factor and a complement derived chemotactic factor, Gey's medium alone served as a negative control. The method appeared to be very sensitive as concentrations of less than one mg plaque per ml medium gave a clear chemotactic response. Whole human saliva was less chemotactic than dental plaque. Incubation of equal concentrations of plaque extract in both the upper and lower compartments of the Boyden Chamber did not result in a large increase in cell migration, indicating that most cell migration in reaction to dental plaque extract in this system depends on a concentration gradient. The chemotactic factor or factors were present in plaque at the time it was collected, they were readily dissolvable in water, and they were heat stable. The dose range in which dental plaque extract would evoke a chemotactic response was variable and usually very narrow. Replicate tests. yielded highly variable results indicating that this method is not suitable for quantitative comparisons. Extracts of the same dilution were prepared from dental plaque samples from a small population with varying degrees of gingivitis. Differences in chemotactic response to those samples could not be related to the intensity of gingivitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1974.tb00646.x
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  • 6
    Electronic Resource
    Electronic Resource
    Reduction in proportions of dental plaque streptococci following a 5 day topical kanamycin treatment (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 12 (1977), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 5 day topical kanamycin treatment of the dental gingival surfaces in institutionalized mentally retarded subjects significantly reduced the plaque mass on the tooth surfaces compared to a placebo treatment. This reduction occurred in the absence of any mechanical hygiene procedures and lasted for 4 or more weeks, which was longer than the kanamycin could have been expected to be present in the mouth. This suggested that the kanamycin had caused an alteration of the plaque flora which should be discernible by quantitative culturing procedures. Plaque was removed and cultured, using an anaerobic serial dilution procedure, before and after kanamycin or placebo treatments. The reduction in plaque weight was associated with reduced levels of streptococci in the plaque. This could be demonstrated by intergroup comparison of the placebo - and kanamycin treated subjects, and by intragroup comparisons of the kanamycin treated subjects prior to treatment and at 4 and 8 weeks after treatment. The streptococci species accounted for 30% of the plaque colony forming units (CFU) prior to kanamycin treatment. At 4 weeks after treatment, the streptococci had decreased to 3% of the CFU and at 8 weeks after treatment, the streptococci had increased slightly to account for 14% of the CFU. The streptococci appeared to be Streptococcus sanguis and Streptococcus mitis. The observations indicate that the topical kanamycin was effective in reducing supragingival plaque because of its ability to decrease the proportions of streptococci in the plaque.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1977.tb00103.x
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  • 7
    Electronic Resource
    Electronic Resource
    Treatment of periodontal infections due to anaerobic bacteria with short-term treatment with metronidazole (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of clinical periodontology 8 (1981), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract In the present report, five selected periodontal patients were treated for 1 week with metronidazole. Two of the patients had their teeth scaled and root-planed the week they received metronidazole. Prior to treatment, B. asaccharolyticus accounted for 41 % of the cultivable isolates and the spirochetes averaged 29 % of the microscopic count in plaque removed from each of four pockets per patient. The presence of these elevated proportions of periodontopathic bacteria combined with the presence of periodontal pockets and attachment loss suggested that the patients were in a state of an active infectious process involving primarily anaerobic bacteria. If this be the case, then antimicrobial therapy directed against these anaerobes with metronidazole was indicated. The 1-week treatment with metronidazole significantly reduced the proportions of these organisms for up to 6 months after treatment. Coincident with these findings was an improvement in the clinical parameters, especially in those sites that initially had greater than 5 mm pocket or attachment loss. These sites showed a 2 mm or more reduction in pocket depth and an almost 2 mm gain in apparent attachment that was evident 6 months after treatment. The results obtained were in only five patients. However, the magnitude of improvement suggests that antimicrobial therapy directed against anaerobic organisms may be a valuable adjunct to periodontal therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-051X.1981.tb02022.x
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  • 8
    Electronic Resource
    Electronic Resource
    Efficiency of split-mouth designs (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of clinical periodontology 17 (1990), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract The purpose of this paper is (1) to investigate the similarity of the amount, distribution, and, severity of periodontal disease of the within-patient experimental units, (2) to estimate the relative efficiencies of split-mouth designs when compared to whole-mouth designs, and (3) to discuss how stratification on initial pocket depth can result in large differences in the power of the test-statistics in the different disease categories. Periodontal disease characteristics are not always homogeneously distributed over the within-patient experimental units and this heterogeneity can reduce the efficiency of split-mouth designs. In particular, if analyses are stratified on initial pocket depth, sites with an initial probing depth deeper than 6 mm may be small in number and asymmetrically distributed when compared to sites with an initial probing depth less than 6 mm. This may result in large differences of the power of the test statistics among the different disease categories and should lead to a careful interpretation of the statistical significance tests. When disease characteristics are symmetrically distributed over the within-patient experimental units and a sufficient number of sites is present per experimental unit, the split-mouth design can provide moderate to large gains in relative efficiency. In the absence of a symmetric disease distribution, wholemouth clinical trials may be preferable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-051X.1990.tb01060.x
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