ISSN:
1432-1238
Keywords:
Mediastinitis
;
Nocardia asteroides
;
Cardiac transplanation
;
Drug interactions
;
Cyclosporin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Nocardia infection classically occurs in immuno-compromized patients. Only a few cases of mediastinal infection due to this pathogen have been described in the literature. We report a patient who developed mediastinitis due toNocardia asteroides after cardiac transplantation. The treatment was surgical debridment, dressing, sugaring and antibiotic therapy. The emergence of a severe acute renal failure possibly induced by drug interaction between Cyclosporin, cyclines and aminoglycosides, led us to modify the antimicrobial treatment. The intravenous use of Imipenem 2g per day and Ciprofloxacin 400 mg per day for four weeks and then oral Ciprofloxacin 1.5g per day for 1 year, was effective and allowed a good outcome, without any drug interaction with Cyclosporin, adverse effect, graft rejection episode or infection relapse.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01705048
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