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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 66 (2000), S. 313-313 
    ISSN: 1432-0827
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1433-2965
    Keywords: Key words:Bone mineral density – Proximal femur
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: This paper describes data on bone mineral levels in the proximal femur of US adults based on the nationally representative sample examined during both phases of the third National Health and Nutrition Examination Survey (NHANES III, 1988–94), and updates data previously presented from phase 1 only. The data were collected from 14646 men and women aged 20 years and older using dual-energy X-ray absorptiometry, and included bone mineral density (BMD), bone mineral content (BMC) and area of bone scanned in four selected regions of interest (ROI) in the proximal femur: femur neck, trochanter, intertrochanter and total. These variables are provided separately by age and sex for non-Hispanic whites (NHW), non-Hispanic blacks (NHB) and Mexican Americans (MA). NHW in the southern United States had slightly lower BMD levels than NHW in other US regions, but these differences were not sufficiently large to prevent pooling of the data. The updated data provide valuable reference data on femur bone mineral levels of noninstitutionalized adults. The updated data on BMD for the total femur ROI of NHW have been selected as the reference database for femur standardization efforts by the International Committee on Standards in Bone Measurements.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1433-2965
    Keywords: Bone mineral density ; Proximal femur
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This paper describes bone mineral levels in the proximal femur of US adults based on a nationally representative sample of 7116 men and women aged 20 years and older. The data were collected in phase 1 of the third National Health and Nutrition Examination Survey (NHANES III, 1988–1991) using dual-energy X-ray absorptiometry, and included bone mineral density (BMD), bone mineral content (BMC) and area of bone scanned in five selected regions of interest (ROI) in the proximal femur: femur neck, trochanter, intertrochanter, Ward's triangle and total. These variables are provided separately by age and sex for non-Hispanic whites (NHW), non-Hispanic blacks (NHB) and Mexican Americans (MA). BMD and BMC in the five ROI tended to decline with age, whereas area did not. BMD and BMC were highest in NHB, intermediate in MA and lowest in NHW, but areas were highest in NHW, intermediate in NHB and lowest in MA. Men had greater BMD, BMC and area than women in all three race/ethnic groups. Differences by age, sex or race/ethnicity tended to be the largest in Ward's triangle, followed by the femur neck; patterns in the trochanter, intertrochanter and total ROI were reasonably similar to each other. This report provides extensive data on femur bone mineral levels of adults from one of the largest samples available to date and should be valuable as reference data for other studies which examine this skeletal site in adults.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1433-2965
    Keywords: Key words:Bone turnover markers – Clinical management – Osteoporosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Biochemical markers of bone turnover provide a means of evaluating skeletal dynamics that complements static measurements of bone mineral density (BMD). This review evaluates the use of commercially available bone turnover markers as aids in diagnosis and monitoring response to treatment in patients with osteoporosis. High within-person variability complicates but does not preclude their use. Elevated bone resorption markers appear to be associated with increased fracture risk in elderly women, but there is less evidence of a relationship between bone formation markers and fracture risk. The critical question of predicting fracture efficacy with treatment has not been answered. Changes in bone markers as currently determined do not predict BMD response to either bisphosphonates or hormone replacement therapy. Single measurements of markers do not predict BMD cross-sectionally (except possibly in the very elderly), or change in BMD in individual patients, either treated or untreated. On the other hand, research applications of bone turnover markers are of value in investigating the pathogenesis and treatment of bone diseases. Markers have potential in the clinical management of osteoporosis, but their use in this regard is not established. Additional studies with fracture endpoints and information on negative and positive predictive value are needed to evaluate fully the utility of bone turnover markers in individual patients.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Osteoporosis international 3 (1993), S. 177-184 
    ISSN: 1433-2965
    Keywords: Calcium ; Diet ; Hip fracture ; Osteoporosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of dietary calcium on hip fracture risk was examined prospectively using the NHANES I Epidemiologic Follow-Up Study cohort, which is derived from a nationally representative sample of the United States population. A cohort of 4342 white men and postmenopausal women ages 50–74 years at baseline (1971–1975) were observed through 1987 for up to 16 years of follow-up. Quantitative estimates of calcium intake were obtained at baseline from a 24-h recall, while weekly frequency of dairy food consumption was obtained from a qualitative food frequency. By 1987, 44 men and 122 women had experienced a hip fracture according to hospital records or death certificates. In the total sample of women the risk of hip fracture was only slightly lower for the highest quartile compared with the lowest. However, although not statistically significant, the age-adjusted risk of hip fracture was approximately 50% lower in the highest quartile of calcium intake compared with the lowest quartile in the subgroup of women who were at least 6 years postmenopausal and not taking postmenopausal hormone. The low relative risk observed among men, although interesting, must be interpreted cautiously due to small sample size. Adjusting for other risk factors did not appreciably change the results for either sex. The pattern of relative risks for calcium quartiles and by selected cutpoints was not consistent with a dose-response effect of calcium. Our results suggest that calcium may lower hip fracture risk in late menopausal women.
    Type of Medium: Electronic Resource
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