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  • 1
    Electronic Resource
    Electronic Resource
    Cell therapy using microencapsulated 293 cells transfected with a gene construct expressing CYP2B1, an ifosfamide converting enzyme, instilled intra-arterially in patients with advanced-stage pancreatic carcinoma: a phase I/II study (1999)
    Springer
    Journal of molecular medicine 77 (1999), S. 393-398 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001090050366
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Organisation of experimental thrombosis by blood cells (1985)
    Springer
    Virchows Archiv 406 (1985), S. 133-148 
    Details
    ISSN: 1432-2307
    Keywords: Experimental thrombus organisation ; Mononuclear cell ; Mesenchymal transformation ; Mesenchymal cell ; Myofibroblastic cell ; Endothelial cell ; Dualistic genesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To clarify whether thrombus organisation was carried out by local cell activity or by elements of the circulating blood we developed an artifical prosthesis, made of an impermeable polyurethane material with an athrombogenic surface but with a central part consisting of a DACRON velour ring which was thrombogenic. We implanted these devices into the aorta of 10 sheep. In these animals, organisation of the central thrombus by local aortic cells could be excluded. After varying periods of time (2–84 days), the device was removed and the organized thrombus investigated by light and electron microscopy. From our investigations the organisation process with the development of mesenchymal cellular elements proceeded in 3 steps: (1) The activation of the mononuclear macrophage system (2), the appearance of myofibroblastic cells and (3) endothelial formation. The activation of the mononuclear macrophage system is probably induced by chemospecific products of metabolism arising from aging thrombotic material. Apart from mononuclear elements such as monocytes, macrophages, and giant cells we observed fibroblast-like and myofibroblast-like cells. The matrix contained collagen. Endothelium developed on the surface of the organizing thrombus. The final stage was characterized by the formation of a pseudovessel wall, which followed the pattern of the vascular model. Our findings support the hypothesis that a thrombus may be organized by cells derived from the circulating blood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00737081
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  • 3
    Electronic Resource
    Electronic Resource
    The use of 123I-labeled heptadecanoic acid (HDA) as metabolic tracer: Preliminary report (1984)
    Springer
    European journal of nuclear medicine 9 (1984), S. 81-85 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The feasibility of using 123I-heptadecanoic acid (HDA) as a metabolic tracer was studied. Different administration routes of HDA were compared. An intracoronary bolus injection was given to calves (n=3), and an intravenous injection was given to patients (n=4). In addition, we examined the influence of 4-h halothane anesthesia in calves and in patients the impact of an insulin (1.5 IU/kg)+ glucose (1.5 g/kg) infusion on the myocardial kinetics of HDA. Data were accumulated with a scintillation probe in calves (t=50 min) and a gamma camera in patients (t=70 min). In calves after an intracoronary bolus injection of HDA the myocardial time-activity curve could be described by two exponentials. The mean elimination halftime of the initial phase (t a 1/2) was 7.3 min and that of the second phase (t b 1/2) was 35 min. The ratio of the size of the initial and second component at t o was 0.93. Halothane anesthesia prolonged the elimination half-times and reduced the component ratio. The biphasic behavior of the myocardial time-activity curve was maintained in patients after intravenous administration of HDA under basal conditions (initial t a 1/2=8.4 min). However, during infusion of insulin+glucose the decline in the myocardial activity was prolonged and monoexponential. This data shows that insulin glucose, interfering with fatty acid metabolism, influences the myocardial washout of HDA, and thus support its use as a metabolic tracer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00254442
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  • 4
    Electronic Resource
    Electronic Resource
    Arterial supply of the latissimus dorsi muscle: A comparative study in human, sheep, dog, and pig (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Clinical Anatomy 7 (1994), S. 251-256 
    Details
    ISSN: 0897-3806
    Keywords: latissimus dorsi muscle ; arterial supply ; cardiomyoplasty ; Life and Medical Sciences ; Miscellaneous Medical
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The latissimus dorsi muscle (LD) has been the subject of numerous studies, especially because of its variety of possible applications in plastic and reconstructive surgery.The clinical use of functional electrical stimulation (FES) and cardiomyoplasty has raised completely new questions in recent years. It was the aim of our study to find an optimal model for animal experiments for this cardiosurgical method, in which the LD is completely removed from its origin and transferred into the thorax. For this purpose, we compared the LD's arterial supply in animals used in experimental surgery, the sheep, dog, and pig, with the LD's supply in human.For studying the arteries of the LD macroscopically and by X-ray, we used an injection solution of latex and barium sulfate. After injection of the solution the vascularization was photographically documented. Subsequently, the muscle was detached from the neurovascular pedicle and prepared for radiological examination of the arterial vascularization.The planimetric computer-assisted identification of the various areas supplied by arterial branches was based on these radiograms. In order to also assess the weight of the supplied parts, the muscles were gravimetrically analyzed.The study showed that the blood supply in pig is very similar to that of man. This species, therefore, would be best suited for experimental cardiomyoplasty. © 1994 Wiley-Liss, Inc.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ca.980070504
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    Paper (German National Licenses)
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