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  • 1
    Electronic Resource
    Electronic Resource
    Extensive spinal hyperostosis in a patient receiving isotretinoin—progression after 4 years of etretinate therapy (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 14 (1989), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A patient with Darier's disease was discovered to have persistent, asymptomatic cervical and thoracic spinal hyperostoses after receiving isotretinoin for 7 years. The spinal abnormalities have remained asymptomatic but have now progressed following 4 years of etretinate therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1989.tb01993.x
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  • 2
    Electronic Resource
    Electronic Resource
    Visual and cutaneous toxicity which occurs during N-(4-hydroxyphenyl) retinamide therapy for psoriasis (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 11 (1986), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Vitamin A (retinol) has been used both topically and systemically in the treatment of skin disease for approximately 40 years (Berson, 1983). Retinol taken in high doses over a period of time can cause fatigue, headaches, cheilitis, anorexia, peeling of the skin and can cause papillary oedema and hepatotoxicity (Dahl et al., 1977). These symptoms form the hypervitaminosis A syndrome and can be caused by acute or chronic intoxication with vitamin A or vitamin A analogues (retinoids). Because of this toxicity and the only marginal therapeutic benefit, the use of systemic vitamin A declined. Since 1977 two synthetic retinoids, isotretinoin (13-cis-retinoic acid) (Korner & Vollum, 1975) and etretinate (Meyskens et al., 1983) have been found to be of clinical use in the treatment of acne, psoriasis and the disorders of keratinization. These drugs have been found to be of such therapeutic benefit to patients that some of their side-effects (Moon et al., 1979) have become acceptable. The realization of the therapeutic potential of retinoids for skin disease has led to an expansion in retinoid pharmacology research. As a consequence new retinoids are reaching the stage of clinical testing in patients. We report our experience of unusual side-effects which occur during a phase II clinical trial of (N-[4-Hydroxyphenyl] retinamide)(4HPR) in the treatment of severe chronic plaque psoriasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1986.tb00520.x
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  • 3
    Electronic Resource
    Electronic Resource
    Carbohydrate metabolism in lichen planus (1976)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 95 (1976), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A study of forty patients with active lichen planus and a negative family history for diabetes showed that 42%, had unequivocally abnormal oral glucose tolerance. The pattern of insulin response to glucose is similar to that seen in typical mild maturity-onset diabetes. There was no association between the presence of glucose intolerance and the duration or type of lesions. None of the patients with glucose intolerance had demonstrable islet-cell antibodies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1976.tb15530.x
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  • 4
    Electronic Resource
    Electronic Resource
    Factors influencing anthralin irritancy (1986)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 115 (1986), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1986.tb02114.x
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  • 5
    Electronic Resource
    Electronic Resource
    Cutaneous phototoxicity reactions (1986)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 115 (1986), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This paper reviews some potential mechanisms of cutaneous phototoxicity and discusses selected methods of predicting and ranking phototoxic reactions.Phototoxicity is a non-immunological reaction that is induced by the action of light on a photoactive chemical. The phototoxic chemical may be either exogenous or endogenous, and if exogenous may include topical or systemic agents. Examples of phototoxic agents include psoralens (e.g. 5-methoxypsoralen, 8-methoxypsoralen, as well as the isopsoralens). Psoralens are used therapeutically for the treatment of different skin diseases and psoralen-like chemicals may be present in perfumes and cosmetics.Phototoxic reactions can be evaluated visually in animals. The hairless mouse has also proved useful with skin thickening as a marker of dermal oedema and the induction of polyamine biosynthetic enzymes, as well as other biochemical changes being indicative of cutaneous phototoxicity. In vitro tests of phototoxicity include the Candida albicans assay as well as bacterial mutagenicity. For example, in the latter category different psoralens vary in their ability to induce mutagenicity in Salmonella typhimurium strains, an assay which can provide rapid screening of potential phototoxicity of chemicals.For human testing, phototoxic chemicals can be delivered topically or orally, and in conjunction with appropriate ultraviolet radiation will produce phototoxic reactions which can be evaluated for intensity of response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1986.tb02116.x
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  • 6
    Electronic Resource
    Electronic Resource
    Cutaneous polyamines in psoriasis (1982)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 107 (1982), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The polyamines putrescine, spermidine and spermine are intimately associated with cellular growth and division. Previous studies ofthe polyamines and their rate limiting biosynthetic enzyme, ornithine decarboxylase, in psoriasis have shown significant changes compared with non-psoriatic skin. We have further studied cutaneous polyamines in patients with psoriasis and in normal subjects. Epidermal shave biopsies were taken and assayed for ornithine decarboxylase activity and polyamine levels. Psoriasis lesions showed increased ornithine decarboxylase activity compared with vminvolved skin. The levels of ornithine decarboxylase activity in uninvolved psoriasis skin were also higher than in normals. There was increased putrescine in involved psoriasis compared with uninvolved and normal skin. Spermidine and spermine were increased in psoriasis skin and in vminvolved skin and compared with normals. The spermidine/spermine ratio was greatest in involved skin compared with uninvolved and normal.These results confirm abnormal polyamine metabolism in both the involved and uninvolved skin of psoriatics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1982.tb00285.x
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  • 7
    Electronic Resource
    Electronic Resource
    Electron-beam treatment of scleromyxoedema (1982)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 106 (1982), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 42-year-old man is described with progressive scleromyxoedema. Clinical features included the development of transient central nervous system symptoms and a 5-year delay before the appearance of an IgG lambda-chain paraprotetnaemia.Electron beam therapy resulted in significant improvement which lasted for 18 months.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1982.tb04539.x
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  • 8
    Electronic Resource
    Electronic Resource
    The place of botulinum toxin type A in the treatment of focal hyperhidrosis: reply from authors (2005)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 153 (2005), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2005.06789.x
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  • 9
    Electronic Resource
    Electronic Resource
    Topical photodynamic therapy in clinical dermatology (2004)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 150 (2004), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The growing incidence of cutaneous malignancies each year necessitates the development of new and more effective methods for both the diagnosis and the treatment of cancerous lesions, while assuring better cosmetic results and improving patient satisfaction. With that in mind, the use of topical photodynamic therapy (PDT) has been explored in the treatment as well as the diagnosis of various cutaneous malignancies. Using the intrinsic cellular haem biosynthetic pathway and principles of photoillumination, topical PDT carries the goal of selectively targeting abnormal cells, while preserving the normal surrounding structures. This paper will discuss the various applications and data on the use of topical PDT in dermatology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2004.05940.x
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  • 10
    Electronic Resource
    Electronic Resource
    A review of peripheral nerve blockade as local anaesthesia in the treatment of palmar hyperhidrosis (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 149 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Injection of botulinum toxin type A (BTX-A) is an effective method of controlling palmar hyperhidrosis. It is, however, an uncomfortable procedure without adequate anaesthesia. We outline the techniques used, the reasons for them and potential pitfalls that can be avoided, with an outline of the neural anatomy relevant to the palmar injection of BTX-A. We have been using peripheral nerve blockade as local anaesthesia during BTX-A treatment of palmar hyperhidrosis for the last few years, and have found it an effective method of providing pain relief during the procedure, giving greater anaesthesia than that given by topical anaesthetic cream under occlusion and ice. It has been our experience that patients prefer wrist blockade to topical anaesthesia and ice when receiving BTX-A injections for treatment of palmar hyperhidrosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2003.05593.x
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