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  • 1
    Electronic Resource
    Electronic Resource
    Structural Alterations after in vivo Administration of Phytohaemagglutinin (1968)
    [s.l.] : Nature Publishing Group
    Nature 218 (1968), S. 268-269 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1. Thymus of mouse injected 6 days earlier with PHA. Limit between the cortical and medullary areas disrupted by the presence of several immature (B) transitional cells and oedema. The number of small lymphocytes (L) is markedly diminished. Haematoxylin-eosin x 300 Fig. 2. Lymph nodes of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/218268a0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Immunotherapy of metastases of human neoplastic cells grown in immunodeficient mice (1982)
    Springer
    Cancer immunology immunotherapy 12 (1982), S. 135-140 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hereditarily athymic (nude) and asplenic-athymic (lasat) mice were inoculated neonatally with 107 K-562 pluripotential leukemia cells of human origin. Meningeal infiltration and/or multiple metastases were found in the lungs, kidneys, and lymph nodes in nearly 60% of mice. Twice as many lasat mice as nude mice had meningeal and lymph node infiltrations. This result indicates that the spleen of nude mice influences the infiltrations and/or the distribution of metastases. Metastases of K-562 cells were found as early as 10 days and as late as 115 days of age. Goat immune gamma (γ)-globulin, prepared from antiserum to K-562 cells and absorbed with peripheral leukocytes and bone marrow cells from normal individuals, markedly diminished the incidence of metastases of K-562 cells. About 16% of the mice treated with immune γ-globulin had metastases in the lungs only. All mice receiving the immune γ-globulin had peripheral monocytosis and lymphocytosis as well as a hyperplasia of the bone marrow monocytic series. Immune γ-globulin may lyse heterotransplanted leukemia cells by direct binding to leukemia cells in the presence of complement and/or may activate antibody-dependent effector cells, for example macrophages or killer cells, which would destroy the transplanted leukemia cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00205371
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  • 3
    Electronic Resource
    Electronic Resource
    Arrest and extravasation of neoplastic cells (1982)
    Springer
    Virchows Archiv 396 (1982), S. 73-89 
    Details
    ISSN: 1432-2307
    Keywords: Human malignant cells ; K-562 cell line ; Vascular arrest ; Endothelial attrition ; Extravasation ; Nude and lasat mice ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The morphological aspects of the arrest and extravasation of malignant cells of human origin (K-562 cell line) in the lungs of athymic (nude) and asplenic-athymic (lasat) mice were studied by electron microscopy examination of serial sections. The specimens were obtained at sequential stages after the sc inoculation into newborn mice of 107 malignant cells. K-562 cells (105) were also injected iv into control groups of nude and lasat mice to assess the influence of the route of inoculation on the in vivo behavior of K-562 cells. Our results demonstrated that K-562 cells were arrested and proliferated within the pulmonary capillaries without the participation of platelets or fibrin. The neoplastic cells extravasated by attrition and penetration of the endothelium (rather than by diapedesis) and continued to proliferate in the interstitial tissue of the lung, developing into neoplastic nodules. Following iv injection, K-562 cells induced the formation of platelet-tumor cell aggregates within the pulmonary capillaries. However, under these conditions, the neoplastic cells did not adhere to the endothelium nor did they proliferate or extravasate. These aggregates were flushed out by the circulation, restoring the permeability of the capillaries.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428501
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  • 4
    Electronic Resource
    Electronic Resource
    Inhibition of marrow granulocytic colony formation by phytohemagglutininAided by grant T-559 from the American Cancer Society. (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 82 (1973), S. 277-283 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The effect of phytohemagglutinin (PHA) on the growth and number of granulocytic colonies (GC) developing on agar from bone marrow and spleen cells of normal and erythroleukemic mice inoculated with Rauscher leukemogenic virus was studied. Equal number of marrow cells from erythroleukemic mice produced twice as many colonies as those from normal mice. The number of GC developing from either normal and leukemic spleen cells was only 20% to 25% of that arising from marrow cells. The number of cells within each colony was significantly larger in GC formed by myelogenous leukemic cells than those arising from normal cells even though they had similar morphologic features. The addition of 100 μg of PHA per 105 cells reduced the number of GC arising from normal and leukemic cells by 35% and 50%, respectively. Treatment with periodate which mainly inhibits its mitogenic activity, abolished the inhibitory effects of PHA on proliferation of granulocytic cells.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040820216
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