Electronic Resource
Palo Alto, Calif.
:
Annual Reviews
Annual Review of Pharmacology
41 (2001), S. 535-567
ISSN:
0362-1642
Source:
Annual Reviews Electronic Back Volume Collection 1932-2001ff
Topics:
Medicine
,
Chemistry and Pharmacology
Notes:
Abstract Drug interactions have always been a major concern in medicine for clinicians and patients. Inhibition and induction of cytochrome P450 (CYP) enzymes are probably the most common causes for documented drug interactions. Today, many pharmaceutical companies are predicting potential interactions of new drug candidates. Can in vivo drug interactions be predicted accurately from in vitro metabolic studies? Should the prediction be qualitative or quantitative? Although some scientists believe that quantitative prediction of drug interactions is possible, others are less optimistic and believe that quantitative prediction would be very difficult. There are many factors that contribute to our inability to quantitatively predict drug interactions. One of the major complicating factors is the large interindividual variability in response to enzyme inhibition and induction. This review examines the sources that are responsible for the interindividual variability in inhibition and induction of cytochrome P450 enzymes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1146/annurev.pharmtox.41.1.535
Permalink
| Library |
Location |
Call Number |
Volume/Issue/Year |
Availability |
