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  • 1
    ISSN: 1530-0358
    Keywords: Colonoscopy ; Sodium phosphate ; Polyethylene glycol ; Bisacodyl ; Bowel preparation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: The aim of this study was to compare the efficacy and patient tolerance of two bowel preparations for colonoscopy. METHODS: Three hundred twenty-three consecutive patients undergoing colonoscopy were randomly assigned to receive either oral sodium phosphate, or 2 liters of polyethylene glycol solution preceded by the stimulant laxative bisacodyl. Patients were asked to record the effects of the preparation, noting any vomiting, nausea, or abdominal pain, and to determine a discomfort rating on a scale of 1 to 5. One hundred sixty-nine patients were assigned to the oral sodium phosphate solution, and 154 to polyethylene glycol with bisacodyl. Surgeons were blinded to the preparation used and rated the quality of the bowel preparation on a scale of 1 to 5. RESULTS: Ninety-nine percent of patients in the sodium phosphate group drank all of the solution as opposed to 91 percent of patients in the polyethylene glycol with bisacodyl group. Patients in the sodium phosphate group reported significantly less discomfort (P=0.002). No significant difference was reported for vomiting, nausea, or abdominal pain associated with the preparations. The quality of bowel cleansing was considered by the colonoscopists significantly better for the sodium phosphate group than the polyethylene glycol with bisacodyl group (P〈0.000001). CONCLUSIONS: Colonoscopy preparation with sodium phosphate solution is better tolerated and more effective than polyethylene glycol with bisacodyl.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Diseases of the colon & rectum 39 (1996), S. 23-29 
    ISSN: 1530-0358
    Keywords: Constipation ; Slow transit ; Colectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: This study assesses the outcome of a standardized operation performed by two surgeons for severe idiopathic slow transit constipation that was resistant to laxative treatment. METHODS: Fifty-nine consecutive patients, 4 men and 55 women, with a mean age of 42.3 years, underwent colectomy with ileorectal anastomosis. Slow colonic transit was demonstrated in each case. Fifty-two patients were available for follow-up, with median time to follow-up being 42 (range, 3–81) months. RESULTS: Median bowel frequency was 4 per 24 hours. Sixty-nine percent had four or less bowel movements daily. Ten percent used antidiarrheal medication regularly. One patient had a stoma for recurrent severe constipation. Mean continence score was 1.8 (on a scale of 0–20); six patients were incontinent, and four of these six had normal preoperative anal manometry. Fourteen patients (27 percent) had difficulty with rectal evacuation. Preoperative defecating proctography was a poor predictor of postoperative evacuation difficulties. Twenty-seven patients (52 percent) had persisting abdominal pain, but there was a significant improvement in the degree of pain (P 〈0.00001). Forty-seven patients (90 percent) were satisfied with the outcome of the operation (and would elect to have it done again). Dissatisfied patients had recurrent constipation or diarrhea and incontinence. CONCLUSION: Colectomy with ileorectal anastomosis produces a satisfactory functional outcome in the majority of patients undergoing surgery for severe constipation with proven slow colonic transit.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Diseases of the colon & rectum 42 (1999), S. 1000-1006 
    ISSN: 1530-0358
    Keywords: Glyceryl trinitrate ; Anal fissure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: A randomized, double-blind, placebo-controlled trial was performed to test the effect of intra-anal glyceryl trinitrate ointment in patients with chronic anal fissures that would normally have been treated by sphincterotomy. Long-term follow-up was then performed to assess fissure healing. METHODS: Patients with chronic anal fissures were randomly assigned to 0.2 percent topical glyceryl trinitrate ointment or placebo. Anal manometry was performed before treatment, one week later, and 48 hours after treatment ceased at four weeks. Fissure healing was assessed by an observer blinded to the treatment arm. Pain was recorded on a linear analog scale. At the completion of the trial, treatment was continued with glyceryl trinitrate until fissure healing was obtained or lateral sphincterotomy was performed if required for ongoing pain. A long-term follow-up assessment was made at a mean of 29 (range, 25–33) months. RESULTS: There was a significant reduction in anal resting pressure at Week 1 with glyceryl trinitrate (P=0.001) but not placebo, and at Week 4 there was a significant reduction in pain score with glyceryl trinitrate (P=0.001) and placebo (P=0.01) and a significant reduction in fissure grade with glyceryl trinitrate (P=0.0001) and placebo (P=0.02). Forty-six percent of fissures healed with glyceryl trinitrate and 16 percent healed with placebo (P=0.001). At long-term follow-up in 40 of 43 patients, 14 patients (35 percent) had undergone lateral sphincterotomy, and in the remainder who were treated with glyceryl trinitrate there was a significant reduction in pain score (P=0.0002). Seventeen patients attended for repeat manometry and fissures were healed with glyceryl trinitrate in ten (59 percent) cases. High internal sphincter pressures persisted at long-term follow-up in patients successfully treated with glyceryl trinitrate, indicating that the sphincter is the cause rather than effect of anal fissure. CONCLUSION: Topical glyceryl trinitrate produces a successful internal sphincterotomy, which resulted in long-term healing of 59 percent of chronic anal fissures and significant improvement in pain. Internal sphincter spasm is the cause of chronic anal fissure.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    International journal of colorectal disease 10 (1995), S. 91-93 
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Le but de cette étude était de développer une méthode permettant d'examiner l'activité rectale et colique au cours de la défécation dans des conditions phygiologiques afin de déterminer le rôle que joue le côlon dans la défécation. Les sujets se présentent au département de médicine nucléaire le lendemain de l'ingestion orale de DTPA marqués à l'In-111, lorsqu'ils ressentent le besoin urgent d'exonérer. La défécation est réalisée dans un local privé alors même que l'on enregistre la scintigraphie dynamique du côlon et du rectum. Quatorze patients ont été étudiés (8 sujets normaux, 4 avec constipation et 2 avec un syndrome du côlon irritable). Chez 13 des patients, le côlon gauche a été visualisé durant la défécation et l'évacuation a été clairement observée chez 12 patients. Le côlon droit a été visualisé chez 11 patients et l'évacuation chez 7. L'activité d'évacuation segmentaire moyenne du côlon droit est de 20%, du côlon gauche de 32% et du rectum de 66%. L'évacuation du contenu colique survient au cours de la défécation qui n'est ainsi pas qu'un processus d'évacuation rectale. Cette constatation a des implications quant à la compréhension de la pathophysiologie des dyschézies.
    Notes: Abstract The aim of this study was to develop a method by which rectal and colonic activity could be examined during defaecation under physiological conditions, in order to evaluate whether the colon plays a role in defaecation. Subjects presented to the Nuclear Medicine department on the day following ingestion of oral In-111 labelled DTPA, when they developed the normal urge to defaecate. Defaecation took place in a private room while dynamic scintigraphy of the rectum and colon was recorded. Fourteen subjects were studied (8 normal subjects, 4 with constipation, 2 with irritable bowel syndrome). In 13 subjects the left colon was visualized during defaecation and emptying was clearly observed in 12. The right colon was visualised in 11 subjects and emptying was seen in 7. Mean percentage segmental evacuation was right colon 20%, left colon 32% and rectum 66%. Colonic emptying occurs during defaecation, which is not a process of rectal evacuation only. This has implications for the understanding of the pathophysiology of obstructed defaecation.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    International journal of colorectal disease 11 (1996), S. 29-33 
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les résultats de tests de l'électrosensibilité de la muqueuse rectale ont été utilisés pour soutenir des théories concernant l'étiologie à la fois de la constipation idiopathique et des dysfonctionnements coliques après rectopexie. Le but de cette étude était de déterminer la validité des tests de l'électro-sensibilité de la muqueuse rectale. Soixante huit patients comprenant 3 groupes (groupe 1: 50 patients soumis à une évaluation dans l'unité de physiologie ano-rectale, groupe 2: 10 patients porteurs d'anastomose colo-anale ou iléo-anale, groupe 3: 8 patients porteurs de stomie) ont été soumis à des tests d'électrosensibilité de la muqueuse rectale avec enregistrement du seuil de stimulation nécessaire pour entrainer une perception. Par ailleurs, l'électrosensibilité de la muqueuse rectale a été mesuréc dans les groupes 1 et 2 en plaçent l'électrode, montée sur un cathéter avec un guide central métallique, contre la paroi antérieure, postérieure, droite et gauche du rectum ou du néo-rectum. Pour déterminer les répercussions sur ce test d'une perte du contact muqueux résultant de la présence de matières fécales, un groupe de 8 patients avec un rectum normal a été testé avec une électrode entourée ou non d'une gaze imprégnée d'eau afin de simuler la présence de matières fécales et de prévenir un contact direct de l'électrode avec la muqueuse rectale. Une grande disparité dans la sensibilité des différentes régions du rectum a été mise en évidence (P〈0.0001). Dans le groupe 1, les seuils moyens étaient de 36,6 mA, sur la paroi antérieure 27,4 mA, la paroi postérieure 37,9 mA, du côté droit 22,3 mA et du côté gauche 25,6 mA. Ces variàtions dans la circonférence suggèrent que c'est davantage le plancher pelvien que la muqueuse rectale qui a été stimulé. Chez tous les patients du groupe 2, les seuils de sensibilité ont été enregistrés et la valeur moyenne était significativement plus élevée que dans les patients du groupe 1 en position centrale (P=0.003), du côté droit (P=0.003) et du côté gauche (P=0.007). Dans le groupe 3, la sensibilité était plus élevée à l'intérieur du stoma, autant au niveau de la musculature de la paroi abdominale qu'au niveau intra-colique ou sous-cutané, suggérant ainsi une origine extra-colique à la perception. Le seuil de sensibilité était significativement plus élevé lorsque l'électrode était enveloppéee de gaze (P〈0.001) et la perte du contact avec la muqueuse n'a pas été détectée par l'appareil d'EMG. En conclusion, la mesure de l'électrosensibilité de la muqueuse rectale ne semble done pas correspondre à une mesure au niveau de la muqueuse et est probablement influencée par le présence de matières fécales.
    Notes: Abstract The results of rectal mucosal electrosensitivity (RME) testing have been used to support theories regarding the aetiology of both idiopathic constipation and bowel dysfunction following rectopexy. The aim of this study was to assess the validity of tests of RME. Sixty-eight patients, comprising three groups (group 1: 50 patients undergoing assessment in the Anorectal Physiology Unit, group 2: 10 patients with coloanal or ileoanal anastomosis, group 3: 8 patients with a stoma) underwent mucosal electrosensitivity testing, with the threshold stimulus required to elicit sensation being recorded. In addition the RME was measured in groups 1 and 2 when placing the electrode, mounted on a catheter with a central wire, against the anterior, posterior, right and left rectal or neorectal walls. To assess the influence on this test of loss of mucosal contact due to faeces, a further 8 cases with a normal rectum had RME performed with and without a layer of water soaked gauze around the electrode to stimulate faeces and prevent the electrode from making contact with the rectal mucosa. There was marked variance in the sensitivity of the different regions of rectal wall tested (P〈0.0001). In group 1 patients the mean sensitivities were: central 36.6 mA, anterior 27.4 mA, posterior 37.9 mA, right 22.3 mA and left 25.6 mA. This circumferential variation suggests that the pelvic floor rather than rectal mucosa was being stimulated. All patients in group 2 had recordable sensitivities, and the mean sensitivity threshold was significantly higher than group 1 patients in the central (P=0.03), right (P=0.03) and left (P=0.007) positions. In group 3 the sensitivity was greater within the stoma at the level of the abdominal wall muscle than intraabdominally or subcutaneously, again suggesting an extra-colonic origin of the sensation. The sensitivity thresh-old was significantly greater with the electrode wrapped in gauze (P〈0.01), and loss of mucosal contact was not detected by the EMG machine. Therefore RME testing would seem not to measure mucosal sensitivity, and is probably influenced by the presence of faeces.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    International journal of colorectal disease 11 (1996), S. 29-33 
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé. Les résultats de tests de l'électrosensibilité de la muqueuse rectale ont été utilisés pour soutenir des théories concernant l'étiologie à la fois de la constipation idiopathique et des dysfonctionnements coliques après rectopexie. Le but de cette étude était de déterminer la validité des tests de l'électro-sensibilité de la muqueuse rectale. Soixante huit patients comprenant 3 groupes (groupe 1: 50 patients soumis à une évaluation dans l'unité de physiologie ano-rectale, groupe 2: 10 patients porteurs d'anastomose colo-anale ou iléo-anale, groupe 3: 8 patients porteurs de stomie) ont été soumis à des tests d'électrosensibilité de la muqueuse rectale avec enregistrement du seuil de stimulation nécessaire pour entrainer une perception. Par ailleurs, l'électrosensibilité de la muqueuse rectale a été mesurée dans les groupes 1 et 2 en plaçent l'électrode, montée sur un cathéter avec un guide central métallique, contre la paroi antérieure, postérieure, droite et gauche du rectum ou du néo-rectum. Pour déterminer les répercussions sur ce test d'une perte du contact muqueux résultant de la présence de matières fécales, un groupe de 8 patients avec un rectum normal a été testé avec une électrode entourée ou non d'une gaze imprégnée d'eau afin de simuler la présence de matières fécales et de prévenir un contact direct de l'électrode avec la muqueuse rectale. Une grande disparité dans la sensibilité des différentes régions du rectum a été mise en évidence (P 〈 0.0001). Dans le groupe 1, les seuils moyens étaient de 36,6 mA, sur la paroi antérieure 27,4 mA, la paroi postérieure 37,9 mA, du côté droit 22,3 mA et du côté gauche 25,6 mA. Ces variàtions dans la circonférence suggèrent que c'est davantage le plancher pelvien que la muqueuse rectale qui a été stimulé. Chez tous les patients du groupe 2, les seuils de sensibilité ont été enregistrés et la valeur moyenne était significativement plus élevée que dans les patients du groupe 1 en position centrale (P = 0.003), du côté droit (P = 0.003) et du côté gauche (P = 0.007). Dans le groupe 3, la sensibilitéétait plus élevée à l'intérieur du stoma, autant au niveau de la musculature de la paroi abdominale qu'au niveau intra-colique ou sous-cutané, suggérant ainsi une origine extra-colique à la perception. Le seuil de sensibilitéétait significativement plus élevé lorsque l'électrode était enveloppéee de gaze (P 〈 0.001) et la perte du contact avec la muqueuse n'a pas été détectée par l'appareil d'EMG. En conclusion, la mesure de l'électrosensibilité de la muqueuse rectale ne semble donc pas correspondre à une mesure au niveau de la muqueuse et est probablement influencée par le présence de matières fécales.
    Notes: Abstract. The results of rectal mucosal electrosensitivity (RME) testing have been used to support theories regarding the aetiology of both idiopathic constipation and bowel dysfunction following rectopexy. The aim of this study was to assess the validity of tests of RME. Sixty-eight patients, comprising three groups (group 1: 50 patients undergoing assessment in the Anorectal Physiology Unit, group 2: 10 patients with coloanal or ileoanal anastomosis, group 3: 8 patients with a stoma) underwent mucosal electrosensitivity testing, with the threshold stimulus required to elicit sensation being recorded. In addition the RME was measured in groups 1 and 2 when placing the electrode, mounted on a catheter with a central wire, against the anterior, posterior, right and left rectal or neorectal walls. To assess the influence on this test of loss of mucosal contact due to faeces, a further 8 cases with a normal rectum had RME performed with and without a layer of water soaked gauze around the electrode to stimulate faeces and prevent the electrode from making contact with the rectal mucosa. There was marked variance in the sensitivity of the different regions of rectal wall tested (P 〈 0.0001). In group 1 patients the mean sensitivities were: central 36.6 mA, anterior 27.4 mA, posterior 37.9 mA, right 22.3 mA and left 25.6 mA. This circumferential variation suggests that the pelvic floor rather than rectal mucosa was being stimulated. All patients in group 2 had recordable sensitivities, and the mean sensitivity threshold was significantly higher than group 1 patients in the central (P = 0.03), right (P = 0.03) and left (P = 0.007) positions. In group 3 the sensitivity was greater within the stoma at the level of the abdominal wall muscle than intra-abdominally or subcutaneously, again suggesting an extra-colonic origin of the sensation. The sensitivity threshold was significantly greater with the electrode wrapped in gauze (P 〈 0.01), and loss of mucosal contact was not detected by the EMG machine. Therefore RME testing would seem not to measure mucosal sensitivity, and is probably influenced by the presence of faeces.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    International journal of colorectal disease 5 (1990), S. 161-163 
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Strictures of the sigmoid colon continue to pose a diagnostic dilemma. They commonly appear to be due to diverticular disease but carcinoma must always be excluded. In some cases diverticula may be present but in others there is no obvious cause for the stricture. In a series of 1039 consecutive colonoscopies performed between 1984 and 1986, 19 cases of sigmoid stricture that could not be negotiated with the colonoscope were encountered. In each case the cause of the stricture could not be demonstrated. Fifteen patients (79%) underwent laparotomy primarily on clinical grounds or with barium enema findings suggestive of carcinoma. A final diagnosis of diverticular disease was made in nine cases and adenocarcinoma is six cases. Barium enema was a poor predictor of malignancy in a stricture. Four patients were treated conservatively and two of these patients continued to have significant symptoms due to diverticular disease. This experience suggests that sigmoid strictures that prevent the passage of a colonoscope should be resected when the cause of the stricture is not apparent.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    International journal of colorectal disease 2 (1987), S. 93-95 
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 60 patients with idiopathic anorectal incontinence, without neurological disease, there was a significant relationship, shown by regression analysis, between the pudendal nerve terminal motor latency and the extent of perineal descent during straining (r0.59;p〈0.001), and the plane of the perineum on straining (r−0.61;p〈0.001). These data are consistent with the suggestion that perineal descent can lead to stretch-induced damage to the perineal nerves in this condition.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    International journal of colorectal disease 3 (1988), S. 158-160 
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Differences in the left and right pudendal nerve terminal motor latencies have been observed in patients with pelvic floor disorders. Until now the mean value of the left and right pudendal latencies has been used as the index of pudendal neuropathy. In 22 patients of a group of 156 patients studied the pudendal nerve terminal motor latency was abnormally raised on one side only. These patients are thought to have pudendal neuropathy whether or not the mean value of the left and right pudendal latencies is also raised. This observation may have therapeutic implications.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    International journal of colorectal disease 6 (1991), S. 175-176 
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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