ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Porous biodegradable scaffolds are widely used in bone tissue engineering to providetemporary templates for cellular attachment and matrix synthesis. Ideally, the degradation rate in vivomay be similar or slightly less than that of tissue formation, allowing for the maintenance of the scaffoldstructure and the mechanical support during early stages of tissue formation. Eventually, the 3-D spacesoccupied by the porous scaffolds will be replaced by newly formed tissue. In this work, β-tricalciumphosphate/Poly-L lactide (β-TCP/PLLA) scaffolds with different proportions of β-TCP to PLLA wereinvestigated. The effects of β-TCP proportions on degradation rate and mechanical strengths of thescaffolds were evaluated in simulated body fluid (SBF) at 37℃ up to 42 days. Results show that: differentproportions of β-TCP to PLLA have significant influence on degradation behaviors of the scaffolds, andmechanical strengths of the scaffolds with weight proportion of β-TCP to PLLA being 2 to 1 are muchhigher than those of the others during the degradation period. And in this period, the scaffolds biodegradeslowly, and Hydroxyl Carbonate Apatite (HCA) forms in the surface of the material
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.336-338.1545.pdf
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