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  • 1
    Electronic Resource
    Electronic Resource
    THE EFFECTS OF MATURATION ON IN VITRO PROTEIN SYNTHESIS BY MOUSE BRAIN CELLS (1966)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 13 (1966), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1966.tb11950.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Facilitated habituation: Strychnine dose-response effects on neural and behavioral habituation (1971)
    Springer
    Inflammation research 2 (1971), S. 103-117 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of two doses of strychnine sulfate (0.125 mg/kg and 0.500 mg/kg) on mouse neural and behavioral habituation were assessed. Reliable alterations in concurrent neural (spontaneous and evoked) activity and spontaneous behavioral activity were obtained as the result of training. Neural habituation was characterized by higher frequency, lower amplitude EEG activity, reduced hippocampal theta activity, increased amplitudes in early components of visual evoked responses, and transient increases followed by progressive decreases of late component amplitudes of the visual evoked responses. Behavioral habituation appeared as decreased gross activity and changes in mouse orientation to cogent features of the test chamber. Low strychnine doses (0.125 mg/kg) reliably facilitated habituation to light flashes and produced lessened sensitivity to dishabituation stimuli. High strychnine doses (0.500 mg/kg) disrupted habituation and produced heightened sensitivity to dishabituation stimuli. The results were accommodated by a modified dualprocess theory of habituation; single process views of habituation were inadequate. The significance of these results to drug facilitation was discussed in terms of optimal arousal and the mediation of pro- and retroactive influences on learning. The characterization of processes underlying memory storage seems amenable to further clarification using CNS stimulants known to operate on such processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966748
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Facilitation of avoidance conditioning in mice by posttraining administration of Bemegride (1971)
    Springer
    Inflammation research 2 (1971), S. 118-121 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mice were given 50 massed training trials on an active avoidance task (wheel-turn response) on 3 successive days and one subsequent test session given 4 days later. Mice in different groups received I. P. injections of Bemegride (5, 10 or 15 mg/kg) or saline immediately after each training session. On 2nd and 3th day, as well as on the subsequent test given on 7th day, the avoidance responses of mice in the 10.0 and 15.0 mg/kg groups were significantly greater than those of the controls. The degree of facilitation was greatest in animals which performed poorly on the first training session. The findings suggest the drug effects on performance are due to enhancement of memory storage processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966749
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Facilitating effects of Bemegride on retention of a visual discrimination task (1970)
    Springer
    Inflammation research 1 (1970), S. 234-239 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats from three strains were given massed training trials on a brightness discrimination task in an automated apparatus. All animals were trained to a criterion of 9 out of 10 correct responses and retrained to the same criterion 24 hours later. Immediately after reaching criterion on original learning, the animals were injected (I.P.) with either saline or Bemegride (β-ethyl-β-methyl glutarimide; 3.0 or 10.0 mg/kg). The relearning scores (trials to criterion) varied with strain, sex, and drug dose. In general, fewer trials were required during retraining for the Bemegride-treated animals than the saline control animals. The findings support the interpretation that Bemegride enhances learning by altering central nervous system processes underlying memory storage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01968696
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    Paper (German National Licenses)
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