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  • 1
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  • 2
    ISSN: 1573-7225
    Keywords: Environmental exposure ; infection ; ionizing radiation ; multiple myeloma ; occupational diseases ; risk factors ; United States
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: The purpose of this population-based case-control study was to learn whether risk factors differ for the individual immunoglobulin types of multiple myeloma. In particular, we sought to determine whether IgA and IgG myeloma were related to a history of exposure to reported IgA- and IgG-stimulating conditions, respectively, or to a history of selected occupational and physicochemical exposures. The M-component immunoglobulin type was determined from immunoelectrophoresis as reported in medical records, and exposure status was obtained through in-person interviews. IgG (56 percent) and IgA (22 percent) M-components predominated. For 17 percent of cases, no peak was found on immunoelectrophoresis; they were presumed to have light-chain myeloma. Persons with these three types of myeloma did not differ with respect to distributions of age or race, but a somewhat higher proportion of light-chain cases were women (58 percent cf 45 percent of all other cases). Detailed analysis of the IgA and IgG subtypes provided little evidence that they differ with respect to prior immune stimulation or employment in several specific jobs. IgA myeloma, but not IgG myeloma, was associated modestly with a history of exposure to chest and dental X-rays. Our study provides little evidence that IgA and IgG myeloma differ with respect to the risk factors examined.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-7225
    Keywords: Brain ; neoplasms ; child ; theoretical models
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: In a registry-based sample of 361 children with a brain tumor, those whose grandparents and great-grandparents had a history of any kind of tumor were younger at the time of presentation than were those who lacked this family history (p=0.1). In post hoc analyses, the age difference was most apparent among children with cerebral tumors, and when family history was limited to brain tumors and to great-grandparents. These findings are in keeping with the hypothesis that a familial tumor diathesis contributes to an early age at onset of a brain tumor in some children.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-7225
    Keywords: Case-control studies ; diabetes mellitus ; insulin resistance ; ovarian neoplasms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Insulin resistance characterizes non-insulin dependent diabetes (NIDDM). Insulin resistance may coexist in clinical syndromes with hyperestrogenism and hyperandrogenism, suggesting that the ovary may be sensitive to effects of insulin. In addition, insulin-like growth factor-I receptors, which are capable of binding insulin, have been identified in ovarian cancer tissue and are proposed to regulate cell growth. We evaluated the association between a history of diabetes mellitus and ovarian cancer in a case-control study in seven counties in Washington and in Utah (United States) during the years 1975–87. Cases included women newly diagnosed with ovarian cancer over a five-year period who were identified through population-based cancer reporting. Controls similar to cases with regard to age and county of residence were identified via household surveys or random digit dialing. The study included 595 cases and 1,587 controls. Twenty-seven cases (4.5 percent) and 72 controls (4.5 percent) reported a history of diabetes. Logistic regression analysis of the association between diabetes and ovarian cancer controlling for age, body mass index, and race resulted in an odds ratio (OR) of 0.9 (95 percent confidence interval [CI]=0.6–1.5). The OR was not changed with further controlling for prior oral contraceptive use or prior pregnancy. None of the 20 women with nonepithelial tumors (15 of which were stromal tumors) had a history of diabetes (upper CI=4.0). These results, together with findings of two earlier cohort studies, do not support the hypothesis that diabetes is a risk factor for epithelial ovarian cancer.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Cancer causes & control 5 (1994), S. 149-156 
    ISSN: 1573-7225
    Keywords: Latter-day Saints ; lung cancer ; Mormons ; religion ; smoking-associated cancers ; United States
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We calculated age-adjusted incidence rates per 100,000 by religion (Mormon, non-Mormon) for Utah (United States) using the 49,182 cancer cases occurring between 1971–85. For all causes of cancer, the rate in Utah for male members of the Church of Jesus Christ of Latter-day Saints (LDS or Mormons) was about 24 percent less than the comparable US rate. There was a 50-percent lower rate of cancers associated with cigarette smoking among LDS men. Non-LDS (NLDS) men in Utah experienced an incidence of smoking-associated cancers slightly higher than other US men. LDS men had an incidence of those cancers not associated with smoking slightly lower than US men, and NLDS men had a 40-percent higher rate than US men because of higher rates of melanoma and cancers of the lip and prostate gland. LDS women had an all-sites cancer rate 24 percent below the comparable US rate, and a 60-percent lower rate of smoking-associated cancers. The incidence of cancer not associated with smoking was 20 percent lower for LDS women compared with US women and was the result of lower rates of cancers of the colon, breast, and uterine cervix. NLDS women had a 13-percent higher incidence of cancers not associated with smoking because of higher rates of cancers of the lip and breast.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-3610
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We tested the hypothesis that there is an association between the use of asbestos-cement piping for drinking water supplies and the incidence of gastrointestinal and kidney cancer. Cancer incidence in 14 Utah communities that had used predominantly asbestos-cement piping for transporting their drinking water supplies for 20 years or more were compared to 27 Utah communities that had never used asbestos-cement piping. Cancer incidence was tabulated for 11 cancer sites for the years 1967–1976. Increased Standard Incidence Ratios (SIRs) were found for cancer of the kidney in men (SIR 192) and leukemia (a control site) in women (SIR 203). No increased SIRs were found for the opposite sex at these sites or for the other gastrointestinal sites singly or in combination. There was no increase in age-adjusted cancer incidence for the 11 sites in 4 of the 14 study communities that had used asbestos-cement piping for 30 years or more. Limitations of the study were that the water supplies were nonaggressive, and leaching from the pipes was minimal if at all. Furthermore, the latent period for observation was very short, suggesting that these results should be considered preliminary.
    Type of Medium: Electronic Resource
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