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  • 1
    Electronic Resource
    Electronic Resource
    Influence of Weight Gain on Spine Mineral Density in Postmenopausal Women (1999)
    Springer
    Calcified tissue international 64 (1999), S. 380-383 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Bone mineral density — Menopause — Body weight — Weight change.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. We studied the relationships between weight variables and spine bone mineral density (BMD) in 183 postmenopausal women aged 34–76 years. There was a significant positive correlation of current body mass index (cBMI) and % of ideal body weight (IBW) with BMD. Moreover, the increase in BMI and % IBW was also positively and significantly associated with a higher age-adjusted lumbar BMD. Weight gain, estimated as the difference between current body weight and past ``ideal'' body weight, was associated with significant age-adjusted BMD with a threshold of 17%, and postmenopausal women with a gain of over 17% had significantly higher spine BMD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005818
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  • 2
    Electronic Resource
    Electronic Resource
    New Horizons in Applied Musculoskeletal Research (2000)
    Springer
    Calcified tissue international 66 (2000), S. 165-167 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Mechanical bone properties — Osteoporosis — Musculoskeletal system — Arthroplasty — Fractures.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Are you prey to information overload? Do you wonder how you can determine what is useful for your purposes? Do you wonder about the relevance of some articles to your particular discipline? Nowadays, the explosion of information presents problems, perhaps nowhere as significantly as in the fields of the theoretical and applied sciences. Perhaps you are a clinician, an expert in the pathology of and injuries to the musculoskeletal system, needing to keep your clinical practice up to date with relevant new information. Assuming that your interest lies in the clinical application of ideas, Calcified Tissue International can help you resolve any confusion by focusing on modern topics that are of major clinical relevance, for example, improvement of the mechanical properties of the bone, especially in metabolic bone diseases, fracture healing enhancement, bone biological responses at the bone implant interface, musculoskeletal system interactions, the genetic bases of orthopedic disorders, and the possible orthopedic applications of gene therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00013136
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  • 3
    Electronic Resource
    Electronic Resource
    Neutrophil functions in patients with fractures of the upper end of the femur (1993)
    Springer
    Calcified tissue international 52 (1993), S. 415-418 
    Details
    ISSN: 1432-0827
    Keywords: Neutrophils ; Peritrochanteric fractures ; Host defense ; Orthopedic surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary In the present study, neutrophil functions were examinedin vitro in 40 patients suffering from fractures of the upper end of the femur (trochanteric and subcapital). Adherence to nylon, serum chemotaxis, and phagocytosis-bactericidal function were assayed. Three microbial strains, namely,Staphylococcus aureus, S. epidermidis, andPseudomonas aeruginosa, were used for the experiments. Adherence of the patients' neutrophils was found normal. On the contrary, the chemotactic ability of the patients' sera was inferior to that of healthy controls; phagocytosis and bactericidal function were also significantly impaired for all three bacterial strains. The results were independent of fracture site (intracapsular or extracapsular), sex, and age. The observed host defense disorders provide additional information that helps to explain the increased susceptibility of these patients to bacterial infections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00571328
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  • 4
    Electronic Resource
    Electronic Resource
    Prevention of bone loss in early nonsurgical and nonosteoporotic high turnover patients with salmon calcitonin: The role of biochemical bone markers in monitoring high turnover patients under calcitonin treatment (1995)
    Springer
    Calcified tissue international 56 (1995), S. 38-41 
    Details
    ISSN: 1432-0827
    Keywords: Postmenopausal bone loss ; High bone turnover ; Biochemical bone markers ; Nasal salmon calcitonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract Annual bone loss rate was estimated in a group of randomly selected 150 nonsurgical and nonosteoporotic early postmenopausal women, 42–56 years, with the use of the mathematical equation proposed by Christiansen et al. (OSTEOTREND-R) [1]. Fifty-six women were characterized as high turnover patients (estimated annual bone loss more than 2.7%). These high turnover patients were included in a double-blind, placebo-controlled clinical study. Patients were divided into two groups of 28 women each. The first group of patients received 100 IU of salmon calcitonin intranasally daily for 1 year and the second group intranasal spray of placebo daily. Blood and urine biochemical parameters as well as bone mineral content of the spine and proximal forearm were determined initially and at the end of 6 and 12 months. No other side effects were noted apart from discomfort of nasal mucosa in two patients (one in each group). The group of calcitonin-treated patients showed a dramatic decrease in bone loss rate as estimated with the use of biochemical bone markers at the end of 6 and 12 months (3.7% versus 0.8% and 0.0% at the end of 6 and 12 months, respectively, P〈0.001) whereas in the placebo group, bone loss rate remained unchanged (4.2% versus 4.1% and 4.3% at the end of 6 and 12 months, respectively). The calcitonintreated patients showed a significant increase in bone mineral content of spine and proximal forearm (P〈0.001 at the end of 6 and 12 months, respectively). On the other hand, a significant decrease in all measurement sites appeared in the placebo group. In conclusion, our results showed that nasal salmon calcitonin administration can prevent the increased postmenorpausal bone loss in selected high bone turnover patients. The predicted annual bone loss rate, as estimated with the combination of biochemical bone markers, is useful in monitoring the responsiveness of high turnover patients to calcitonin at short intervals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00298742
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  • 5
    Electronic Resource
    Electronic Resource
    Hip Fracture Epidemiology in Greece During 1977–1992 (1998)
    Springer
    Calcified tissue international 62 (1998), S. 542-547 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Hip fracture — Epidemiology.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Hip fracture, the most dramatic complication of osteoporosis, constitutes a serious health problem of the elderly, with great socioeconomic consequences. Hip fracture epidemiology has been studied by many investigators. Until now, reported studies in Greece include either data from only one region, or they do not include all the epidemiological parameters concerning hip fractures. We studied hip fractures that occurred in Greece in 1992 and compared the findings with those of previous years (1977, 1982, 1987), in order to identify age and sex incidence and increase rate during 1977–1992. There has been an average annual increase of 7.6%, thus total hip fractures in Greece increased from 5,100 in 1977 (54.75 fractures/100,000 inhabitants) to 10,953 in 1992 (107.30 fractures/100,000 inhabitants). In 1992, 70% of the patients were women. During the 1977–1992 period, age-adjusted incidence for people aged over 50 increased in both sexes (from 173.54 fractures/100,000 inhabitants in 1977 to 314.07 fractures/100,000 inhabitants in 1992, an increase of age-adjusted incidence of 80.97%). Approximately 50% of the patients in 1992 were aged 80 and over, whereas in 1977 there were only 22.49% patients of the same age. The increase in hip fracture numbers is greater than expected due to population aging, suggesting the existence of other factors influencing this increase. The most affected age group is 80 and over.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900476
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  • 6
    Electronic Resource
    Electronic Resource
    Epidemiology of hip fracture: The MEDOS study (1996)
    Springer
    Osteoporosis international 6 (1996), S. 11-15 
    Details
    ISSN: 1433-2965
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01623757
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  • 7
    Electronic Resource
    Electronic Resource
    The natural history of the osteoporotic vertebral fracture (1989)
    Springer
    Clinical rheumatology 8 (1989), S. 66-69 
    Details
    ISSN: 1434-9949
    Keywords: Osteoporosis ; Vertebral Fracture ; Bone Density
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The clinical picture of the osteoporotic fractures of the spine presents an heterogeneity in their intensity and duration. In 210 cases of osteoporotics with acute pain and radiological evidence of spinal fracture we separate their clinical picture in two groups. In Type I (121 cases) pain is acute and severe, improving gradually; the vertebral wedging is obvious from the beginning and remain unchanged. The duration of this event exceeds 4–8 weeks. In Type II (89 cases) pain is less and of shorter duration, but after 6–16 weeks a new attack of acute pain presents. This picture can be repeated for 6–18 months. Radiologically the fracture is not clear during the first attack but wedging gradually developed during the next months. Bone density of the lumbar spine (DPA) was measured in all cases. Type I had a significantly lower BMC than Type II. We suggest that patients with unclear vertebral fractures, minor symptoms and relatively high bone mass must classified in Group II and deteroriation can occur during the next months. Long term treatment and additional orthopaedic prevention is needed. In Group I a short term calcitonin treatment helps early relief and mobilization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02207237
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  • 8
    Electronic Resource
    Electronic Resource
    The effect of a modified etidronate cyclical regimen on postmenopausal osteoporosis: A four-year study (1997)
    Springer
    Clinical rheumatology 16 (1997), S. 354-360 
    Details
    ISSN: 1434-9949
    Keywords: Bone Mineral Density ; Etidronate ; 1,25-dihydroxyvitamin D3 ; Postmenopausal Osteoporosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To develop an improved treatment schedule for osteoporosis, a study was undertaken in 100 postmenopausal women using a modified ADFR 90-day cyclical regimen with etidronate. After one year of treatment, the etidronate-treated group showed a significant increase in bone density of the spine, which continued over the following 2 years of treatment and remained stable during the fourth year. In contrast, in the non-etidronate group, bone density decreased significantly after four years. In addition, the fracture rate was significantly lower in the etidronate group than in the non-etidronate group. Side effects were minimal in both groups and no serious adverse reactions were reported. In conclusion, it appears that a cyclical regimen using 1,25-dihydroxyvitamin D3, etidronate and calcium increases bone mass and reduces fractures with no significant side effects, thus making a useful contribution in the treatment of postmenopausal osteoporosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02242451
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  • 9
    Electronic Resource
    Electronic Resource
    Correlation of interleukin-6 serum levels with bone density in postmenopausal women (1997)
    Springer
    Clinical rheumatology 16 (1997), S. 162-165 
    Details
    ISSN: 1434-9949
    Keywords: Bone Density ; Bone Markers ; Osteoporosis ; Cytokines ; Interleukin-6
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to identify possible correlations between interleukin-6 (IL-6) and hormonal and biochemical parameters of bone metabolism, or bone density, 24 postmenopausal women were studied. Serum IL-6, estradiol, calcium, phosphorus, osteocalcin, alkaline phosphatase, the urinary secretion of calcium, phosphoru and hydroxyproline, and bone density of the lumbar spine, femur and radius were measured. No significant correlation was found between IL-6 and the biochemical parameters. A negative correlation was found between IL-6 and serum estradiol, as well as between IL-6 and bone density in 5 out of 6 sites studied. It is possible that women with high IL-6 levels, may develop lower bone mass.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02247845
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