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  • 1
    Electronic Resource
    Electronic Resource
    Variable-Region Subgroup and Specificity of Cold Agglutinins (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 8 (1978), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The variable-region subgroup determined by amino acid sequence analysis of heavy and light chains of two monoclonal cold agglutinins with the new anti-Gd specificity is reported. Both proteins belong to the VHI 11 subgroup of heavy chains; one light chain falls into the VKI subgroup, the other has a blocked N-terminus which so far has not been observed in human kappa chains. The comparison of anti-Gd with anti-l/-i or anti-Pr cold agglutinins indicates that anti-Gd differs from other cold agglutinins with respect to variable-region subgroup. The data extend previous findings on the restriction of certain antibodies to distinct variable-region subgroups.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1978.tb00506.x
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  • 2
    Electronic Resource
    Electronic Resource
    Early events in the replication of parvovirus LuIII (1984)
    Springer
    Archives of virology 81 (1984), S. 285-302 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Purified infectious LuIII virions characterized for their biological and physicochemical properties were used to analyse early events in the interaction of an autonomous parvovirus with its host cell. It could be shown that adsorption and penetration of LuIII virus are rapid processes which, under optimal conditions, can be completed within 30 to 60 minutes of incubation at 37° C. Uncoating of the viral genome is initiated in the cytoplasm and is continued after the virus has been transported to the nucleus. None of these processes appeared to depend on cell cycle-specific helper function(s). However, the first step in viral replication—formation of viral parental RF-DNA consisting of covalently linked complementary strands—evidently could only be achieved in late S-phase of the cell cycle. No evidence was obtained which would support the hypothesis that viral DNA must be integrated into the cellular genome to allow for the initiation of viral DNA synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01309999
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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