ISSN:
1573-3904
Keywords:
RGD
;
Antithrombotics
;
GP IIb/IIIa
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary RGD-peptidomimetics are currently being investigated as a class of potential antithrombotics that antagonize the fibrinogen receptor, GP IIb/IIIa, on the surface of platelets. These mimetics are expected to have decisive advantages-such as higher activity and specificity, oral bioavailability and longer duration of action-over known antithrombotics. For further optimization in this respect, novel peptidomimetic GP IIb/IIIa antagonists with an oxazolidinonemethyl central building block were synthesized. This building block proved to be very versatile as an ‘anchor’ for structurally different C-termini and was the starting point for highly efficient and orally active compounds.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00119139
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