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  • 1
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: We have studied the nature and origin of the serotonergic innervation of two distinct anatomical cerebrovascular compartments, namely, small pial vessels and major cerebral arteries, in the rat. To this end, the levels of serotonin [5-hydroxytryptamine (5-HT)] and 5-hydroxyindoleacetic acid (5-HIAA) were measured by HPLC in both cerebrovas-cular compartments after either bilateral sympathectomy or destruction of the ascending serotonergic pathways, which originate from the raphe nuclei. We first showed that the small pial vessel samples were not contaminated by underlying cortical tissues through the use of an immunohistochemical approach that revealed the glia limitans, the most superficial cortical layer. Superior cervical ganglionectomy caused a marked decrease in noradrenaline concentrations in major cerebral arteries (−77%), although the reduction was less pronounced (−34%) in small pial vessels. Sympathectomy decreased by 33% 5-HT concentrations in the major cerebral arteries but was without effect on 5-HT levels in the small pial vessels. Destruction of the ascending serotonergic pathways (via local administration of 5,7-dihydroxytryptamine into the ventral tegmental area) produced a dramatic fall in 5-HT and 5-HIAA concentrations in both vascular compartments. To establish the authenticity of the serotonergic innervation, the synthesis of 5-HT [as assessed by measuring the accumulation of 5-hydroxytryptophan (5-HTP) after decarboxylase inhibition] was measured in the two vascular beds under control conditions and after destruction of the ascending serotonergic pathways. The rate of accumulation of 5-HTP was higher in the small pial vessels than in major cerebral arteries, an observation that indicates an important de novo synthesis of 5-HT in small pial vessels. The neurotoxic lesion of the ascending serotonergic fibers caused a marked reduction of 5-HTP accumulation in small pial vessels (−67%) and a slight but significant decrease (−24%) in major cerebral arteries. These results collectively point to the existence of a true serotonergic innervation of small pial vessels that originates in the rostral raphe nuclei; in contrast, most of the 5-HT present in major cerebral arteries seems to originate from sources other than these nuclei.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 111 (1989), S. 8919-8920 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 101 (1994), S. 2539-2547 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Collisions of inert gases with a perfluorinated liquid over an 85 K range reveal how gas–liquid energy transfer depends on the temperature of the liquid. At higher temperatures, thermal accommodation of impinging Ne, Ar, and Xe atoms grows at the expense of prompt inelastic scattering. The experiments suggest that hotter liquids possess rougher surfaces, which promote multiple collisions that dissipate the atom's incident energy and which may momentarily trap gases in gaps created by incommensurate packing of the surface molecules. The fraction of energy transferred during a high energy impulsive collision remains almost unaltered by changes in the liquid's temperature, implying that impulsive encounters within the scattering plane are dominated by single collision events.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Cytopathology 8 (1997), S. 0 
    ISSN: 1365-2303
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
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    Cambridge : Periodicals Archive Online (PAO)
    The Modern language review. 43 (1948) 34 
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 155 (1945), S. 162-164 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] History NO story of London's water supply would be complete without some brief account of the historical background from which have emerged the methods of purification which now form our vital defences against the transmission of the germs of water-borne disease. Prior to the fourteenth century, ...
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 383 (1980), S. 185-187 
    ISSN: 1432-2013
    Keywords: Adrenoceptor development ; papillary muscle ; cardiac adrenoceptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The postnatal development of positive inotropic responses in ventricular tissue was investigated using isolated rat papillary muscles. Responses to exogenous noradrenaline or isoprenaline were already fully developed in preparations from newborn rats. These newborn preparations were also supersensitive to noradrenaline. Responses to field stimulation of intramural nerves or to tyramine were very low in preparations from animals of up to two weeks in age, but had increased to near adult values by 3 weeks of age. This increase in responsiveness was correlated with a progressive increase in sympathetic innervation revealed by fluorescence histochemistry. It is concluded that β-receptors are present on the ventricular myocardium at birth in the rat, but that positive inotropic responses to sympathetic nerve stimulation do not develop until between 2 and 3 weeks of age.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 173 (1976), S. 129-132 
    ISSN: 1432-0878
    Keywords: Adrenergic innervation ; Noradrenaline uptake ; α-Methylnoradrenaline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The development of noradrenergic innervation was studied in the mouse heart using fluorescence histochemistry. Following incubation of hearts with α-methylnoradrenaline fluorescent nerve fibres were seen as early as 13 days in utero. It is suggested that the neuronal uptake mechanism for noradrenaline is functional at an early stage.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Potato research 35 (1992), S. 93-102 
    ISSN: 1871-4528
    Keywords: softness ; mealiness ; water potential
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary It has been disputed whether, when potato starch gelatinises and absorbs water, it generates an osmotic or matric pressure that makes the potato cells become round and separate from one another. Starch suspensions heated at 100°C in dialysis bags absorbed water, suggesting that starch swelling pressure does exist. It was quantified by heating starch suspensions at 85°C in a chamber which absorbed water through a membrane and contained an argon bubble whose volume was measured. This gave starch swelling pressures around 100 kPa, increasing non-linearly with starch concentration. A comparable estimate (a few hundred kPa) of starch swelling pressure within cooked potato tissue was obtained from the fact that it largely prevented the tissue contraction expected due to loss of turgor pressure in the first 1.5 min of boiling. A slight expansion thereafter was attributed to the combined effect of starch swelling pressure and cell wall and middle lamella degradation.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Plant and soil 33 (1970), S. 483-485 
    ISSN: 1573-5036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Significantly higher contents of boron, molybdenum and zinc were observed in cabbages in urban than in rural areas. The levels of extractable boron, copper, lead, nickel and zinc were markedly enhanced in the urban soils but there was no corresponding enhancement of the levels of copper, lead and nickel in the cabbages.
    Type of Medium: Electronic Resource
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