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  • 1
    Electronic Resource
    Electronic Resource
    A scanning electron microscopic study of normal human oxyntic mucosa using blunt dissection and freeze fracture (1978)
    Springer
    Digestive diseases and sciences 23 (1978), S. 449-459 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Biopsies from the fundic mucosa of healthy volunteers were examined by scanning electron microscopy following blunt dissection and freeze fracture. The mucosal surface exhibited a cobblestone appearance. With increased magnification, microvilli could be demonstrated on the luminal surface of individual surface cells. Blunt dissection of the gastric mucosa revealed tubular gastric pits descending from the surface until they opened into branched tubular gastric glands. The gastric glands are irregular in outline due to the knoblike projections of individual parietal cells. The internal structure of the component cells also was examined with the scanning electron microscope following freeze fracture. Mucous granules were observed in the apical portion of surface epithelial cells. Lumina of parietal cell canaliculi were found to be continuous with the lumen of the gastric glands. Pepsinogen granules could be seen throughout the cytoplasm of chief cells. The blunt dissection-freeze fracture technique utilizing the scanning electron microscope allows, for the first time, a three-dimensional view of human gastric mucosa, including the gastric pits and glands as well as some of the internal architecture of component cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01072929
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Morphological observations on the normal human cardiac glands (1978)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 192 (1978), S. 59-71 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The majority of human cardiac glands that lie immediately distal to the termination of esophageal epithelium are compound or branched tubular glands. They empty into overlying gastric pits. The glands of this region are often organized into lobule-like complexes by the surrounding connective tissue of the lamina propria. The secretory tubules contain mucous cells, parie-tal cells and endocrine cells. The mucous cell is the most common cell type observed and appears to comprise two populations. The majority are pyramidal in shape and show numerous spherical, electron-dense secretory granules. Profiles of rough endoplasmic reticulum are observed scattered throughout the cytoplasm and Golgi complexes occupy a supranuclear position in relation to forming secretory granules. Morphologically this cell type appears similar to the mucous neck cell of the fundus. Secretory granules of a second mucous cell type are mottled in appearance and show an area of increased electron density near the limiting membrane. Parietal cells are observed and appear identical to those in the fundus. The large number of endocrine cells present raises questions concerning the traditional concept of the function of these particular glands.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091920106
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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