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  • 1
    Electronic Resource
    Electronic Resource
    Performance of the VERSANT® HIV-1 Resistance Assays (LiPA) for detecting drug resistance in therapy-naive patients infected with different HIV-1 subtypes (2003)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS immunology and medical microbiology 39 (2003), S. 0 
    Details
    ISSN: 1574-695X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: In this study we evaluated the performance of the VERSANT® HIV-1 Resistance Assays (LiPA) in detecting drug resistance in therapy-naive HIV-infected patients diagnosed in Belgium in 2000. We compared the results with population sequencing and found concordance to be in line with previous studies in treatment-experienced patients (86.87% for reverse transcriptase (RT); 92.77% for protease (PRO)). Discordance was mainly due to indeterminate reactions on LiPA (8.45% for RT; 6.85% for PRO) and minor discordances (4.13% for RT; 0.25% for PRO). Major discordances were rare (0.46% for RT; 0.12% for PRO). Indeterminate reactions were significantly associated with strains belonging to non-B subtypes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0928-8244(03)00240-2
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Gastric emptying andHelicobacter pylori infection in duodenal ulcer disease (1996)
    Springer
    Digestive diseases and sciences 41 (1996), S. 462-468 
    Details
    ISSN: 1573-2568
    Keywords: Helicobacter pylori ; duodenal ulcer ; gastric emptying ; [13C]urea breath test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pathogenetic link betweenHelicobacter pylori gastritis and duodenal ulcer is still unknown. Fast gastric emptying of liquids might be important in the pathogenesis of gastric metaplasia of the duodenum and duodenal ulcer through an increased exposure of the duodenum to gastric acid. InH. pylori-infected subjects, an abnormal gastric emptying could affect urea breath test results and correlate with the histological gastritis. This study was performed to evaluate the gastric emptying of liquids in duodenal ulcer patients withH. pylori infection and the possible relation between the bacterial load, gastric emptying, and urea breath test results. Seventeen duodenal ulcer patients withH. pylori gastritis and 15 healthy volunteers were studied by a combined [14C]octanoic acid and [13C]urea breath test to evaluate gastric emptying rate andH. pylori status simultaneously. Endoscopy with antral biopsies was performed in all duodenal ulcer patients. Duodenal ulcer patients withH. pylori infection have a normal liquid gastric emptying that is unrelated with the histological severity of gastritis. The urea breath test results and the gastric emptying parameters do not correlate with histology. A significant correlation between the gastric emptying and the urea hydrolysis rate is found. It is concluded thatH. pylori infection in duodenal ulcer patients is not associated with abnormally fast liquid gastric emptying, and this finding should be taken into account when a causal link betweenH. pylori infection and duodenal ulcer disease is searched for. The correlation between gastric emptying and urea hydrolysis rate explains why no conclusions on intragastric bacterial load can be drawn from the urea breath test results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02282319
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Gastric Emptying Rate of Solids in Patients with Nonulcer Dyspepsia (1997)
    Springer
    Digestive diseases and sciences 42 (1997), S. 1158-1162 
    Details
    ISSN: 1573-2568
    Keywords: OCTANOIC ACID ; GASTRIC EMPTYING ; BREATH TEST ; NONULCER DYSPEPSIA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The underlying role of motility disorders anddelayed gastric emptying in nonulcer dyspepsia is stillquestioned. This study aimed to determine the role ofthe gastric emptying rate of solids in patients with nonulcer dyspepsia. By means of breathtest technology, gastric emptying results of 344consecutive patients with nonulcer dyspepsia werecompared with those of 70 normal healthy volunteers.Although gastric emptying was significantly delayed inpatients with nonulcer dyspepsia compared with normalvolunteers, there was a great overlap between the twogroups. Using 5-95% confidence intervals of the control group in about 30% of the patients withnonulcer dyspepsia gastric emptying was delayed. Nocorrelation was found between gastric emptying rate andage, weight, height, or sex of the subjects in both groups. These findings suggest that, apartfrom gastric emptying, other mechanisms are veryimportant in the etiology of nonulcerdyspepsia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018881419010
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Increased permeability of macroscopically normal small bowel in Crohn's disease (1994)
    Springer
    Digestive diseases and sciences 39 (1994), S. 2170-2176 
    Details
    ISSN: 1573-2568
    Keywords: [51Cr]EDTA ; PEG-400 ; intestinal permeability ; Crohn's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To investigate permeability alterations of the macroscopically normal jejunum in Crohn's disease, the permeation of two probes was measured during perfusion of an isolated jejunal segment. The data were compared with the results obtained by the standard per oral test in the same patients. Test probes were PEG-400 and [51Cr]EDTA. Ten normal individuals, 12 patients with Crohn's ileitis or ileocolitis, and seven patients with isolated Crohn's colitis all with normal jejunum on x-ray series were studied. Upon perfusion of the proximal small bowel, the 3-hr [51Cr]EDTA excretion was significantly increased in ileitis patients (P=0.023) as compared to normals. The excretion exceeded the highest value of normals in eight of 12 ileitis patients. The excretion in Crohn's colitis patients was not significantly increased (P=0.24) and abnormal excretion was found only in one of the Crohn's colitis patients. PEG-400 permeation during perfusion did not differentiate between the groups, but five of the seven patients with isolated Crohn's colitis had PEG-400 excretion exceeding the highest value in normals. Overall, 13 of the 19 patients had increased permeation of one of the two probes through jejunal mucosa during perfusion. These data suggest that the permeability is increased in the majority of patients even in segments that seem normal on x-ray.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02090367
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    Paper (German National Licenses)
    Fulltext
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