ISSN:
1420-908X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Histamine release was studied in patients undergoing cholecystectomy, renal transplanatation and cardiopulmonary bypass (CPB). Plasma histamine rose in response to anaesthesia and surgery. In cholecystectomy patients the rise was not associated with any clinical events, and not affected by the use of preoperative H1+H2 receptor antagonists. In one patient a maximal histamine concentration of 14.0 ng/ml was measured. Similarly, in fourteen transplant patients no remarkable clinical conditions were associated with the elevated plasma histamine in the perioperative period. Five of those patients were found to have doudenal ulcer and two had duodenitis at endoscopy after operation. They had significantly higher histamine concentrations than the seven patients with a normal duodenum in the first ten days after surgery. During CPB, significant rises in plasma histamine occurred at the onset of CPB and in the immediate post-CPB period when spontaneous circulation was resumed. One CPB patient who was asthmatic developed marked bronchospasm at the end of bypass perfusion, which was associated with persistently high histamine. Thus, histamine release following surgery may be a factor in certain clinical situations. Individual high values, however, may not give any clinical consequence.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01997327
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