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  • 1
    Electronic Resource
    Electronic Resource
    Nucleus Reticularis Thalami and Neocortical Paroxysms in the Rat (1995)
    Oxford, UK : Blackwell Publishing Ltd
    European journal of neuroscience 7 (1995), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The role of the nucleus reticularis thalami in spike-wave discharges in rats with genetic absence epilepsy has already been demonstrated. This study further investigated the role of the nucleus reticularis thalami in paroxysmal synchronizations in Sprague-Dawley rats; this strain shows no propensity to epileptic activity. Electroencephalographic patterns were followed in chronically implanted, unrestrained rats. After both electrolytic and chemical unilateral lesions, stereotaxically placed in the anterolateral sectors of this nucleus (verified post mortem), abnormal electroencephalographic rhythms (high-voltage polyspikes and spike-wave complexes) were recorded from the frontoparietal cortex, primarily in the contralateral hemisphere. Stereotyped discharges at 3 Hz developed progressively from multiple spikes within the alpha frequency range through the lengthening of the wave component. The excessive synchronized activity recorded from the intact hemisphere was of greater amplitude and occurred slightly earlier than from the lesioned hemisphere. These EEG patterns were associated with behavioural manifestations closely resembling those seen during absence seizures in humans. Bilateral lesions did not induce paroxysmal activity, both hemispheres being characterized by dominant delta/theta activity without signs of EEG-synchronized sleep. The seizures may thus have been due to disinhibition of the contralateral reticularis nucleus, recently shown to project to the reticularis nucleus of the other side in rats. This working hypothesis is supported by callosal cuts. The results indicate that the reticular neurons exert a control over neocortical paroxysmal activity even in animals which do not present genetic absence epilepsy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-9568.1995.tb00651.x
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  • 2
    Electronic Resource
    Electronic Resource
    Nystagmus induced by Unilateral Labyrinthectomy affected by Sleep–Wakefulness Cycle (1967)
    [s.l.] : Nature Publishing Group
    Nature 215 (1967), S. 62-63 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The experiments were performed on cats. Screw type electrodes were implanted, under ?Nembutal? anaesthesia, in the skull for electroencephalogram recording and in the superior wall of the orbital cavity of each side, after the frontal sinuses had been opened, for recording ocular movements. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/215062a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Sciatic Nerve Activity evoked by Sensory-motor Cortex Stimulation during Paradoxical Sleep (1966)
    [s.l.] : Nature Publishing Group
    Nature 209 (1966), S. 1030-1030 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The aim of the present investigation was to study the behaviour of sciatic nerve responses to sensory-motor cortex stimulation during sleep and wakefulness, in order to obtain further information on the function of the cortico-spinal system during these physiological phases. The experiments were ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2091030a0
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  • 4
    Electronic Resource
    Electronic Resource
    Depolarization of afferent fibers to the goll and burdach nuclei induced by stimulation of the brain-stem (1968)
    Springer
    Experimental brain research 5 (1968), S. 1-15 
    Details
    ISSN: 1432-1106
    Keywords: Dorsal column nuclei (DCN) ; Primary afferent depolarization (PAD) ; Presynaptic inhibition ; Brain-stem reticular formation ; Centrifugal control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. In nembutalized cats the excitability of superficial radial (SR) and superficial peroneus (SP) primary afferents was tested by microelectrode stimulation (Wall's technique) within the dorsal column nuclei (DCN). SR and SP excitability increased for over 100 msec after conditioning stimulation of the brain-stem with a maximal effect at 50 msec interval. The conditioning curves did not change in decerebrated and cerebellectomized preparations. 2. In nembutalized intact and decerebrated cats a negative slow potential change (over 150 msec) was recorded from one isolated dorsal column (dorsal column potential, DCP) following stimulation of the brain-stem. In the same type of preparations the brain-stem stimulation induced from DCN surface a prolonged (over 150 msec) positive potential (P-wave) which inverted within the nuclei. 3. Interaction experiments have revealed an inhibitory effect of conditioning brain-stem stimulation on SR induced surface P-wave. The effect was maximal at 50 msec interval and was present up to 200 msec. SR stimulation also depressed the brain-stem induced P-wave for over 150 msec but with a maximal effect within the first 20–30 msec. 4. The effects reported above were maximal when the caudal-most brain-stem regions were stimulated. They were still present in control experiments where the sensorimotor cortex had been widely removed 15 days previously.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00239901
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  • 5
    Electronic Resource
    Electronic Resource
    Desynchronized (REM) sleep inhibition induced by carbachol microinjections into the nucleus basalis of Meynert is mediated by the glutamatergic system (1996)
    Springer
    Experimental brain research 109 (1996), S. 174-178 
    Details
    ISSN: 1432-1106
    Keywords: Basal forebrain ; Sleep ; Glutamate antagonist ; Cholinergic system ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this paper was to study the effects of microinjections of carbachol, a mixed cholinergic agonist, into the nucleus basalis of Meynert (NBM) of rats on the wake-sleep cycle. Carbachol (2.74 nmol) was able to increase wakefulness (W) and decrease desynchronized sleep (DS). To verify the hypothesis that the effects of carbachol are at least partially mediated by the glutamatergic system, the NMDA antagonist 2-amino-5-phosphonopentanoic acid and the non-NMDA antagonist d-γ-glutamylaminomethanesulfonic acid were injected into the NBM before carbachol. Pretreatment with these glutamate receptor antagonists counteracted the effect of carbachol on DS. The effect of carbachol on W was not modified by the pretreatment with the glutamate receptor antagonists. This is the first study showing that carbachol injected into the NBM increases W and decreases spontaneous DS in the rat. Moreover, our results tend to indicate that the decrease in DS following the injection of carbachol into the NBM is related to the release of endogenous glutamate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00228641
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    Paper (German National Licenses)
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